A5023557175- Synthesis and biological activity
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical and Physical Properties in Aqueous Solutions
- Photochemistry and Electron Transfer Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Protein Interaction Studies and Fluorescence Analysis
- Adsorption and biosorption for pollutant removal
- Bioactive Compounds and Antitumor Agents
- Hops Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Ionic liquids properties and applications
- Advanced Cellulose Research Studies
- Drug Transport and Resistance Mechanisms
- Mesoporous Materials and Catalysis
- Chemical Reaction Mechanisms
- Antioxidant Activity and Oxidative Stress
- Synthesis and Biological Evaluation
University of Belgrade
2015-2024
University of Belgrade – Faculty of Chemistry
2021-2023
National Institute of Chemistry
2019-2023
Institute of Pesticides and Environmental Protection
2019
As a functional extraction medium, natural deep eutectic solvents (NADESs) can dissolve various plant metabolites. Those provide untapped potential for creating novel green extracts with distinctive phytochemical signatures and unique biological activities. This is particularly relevant given the rising need eco-friendly sustainable skin care products. The main aim of this work was to optimize most efficient extracting bioactives from 18 medicinal herbs applicable cosmetic industry....
To replace common organic solvents that present inherent toxicity and have high volatility to improve the extraction efficiency, a range of natural deep eutectic (NADESs) were evaluated for phenolic compounds from Agrimonia eupatoria. Screening NADES efficiency was carried out based on total flavonoid content radical-scavenging activity, determined by spectrophotometry, as well quantified, obtained using ultra-high-performance liquid chromatography with diode array detector triple-quadrupole...
A new Zn(<sc>ii</sc>)-based complex shows a concentration-dependent apoptotic response in highly resistant pancreatic adenocarcinoma cells with extensive activation of caspase-8 and -9.
Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment DNA replication via the ROS-independent pathway. The structural similarity thiocarbohydrazone to previously published thiosemicarbazone catalytic inhibitors targeting ATP-binding site human topoisomerase IIα prompted us investigate inhibition on this target....
Dynamic properties at the liquid–vapor interface of water are investigated 298 K on basis molecular dynamics simulations and intrinsic surface analysis. The mean residence time diffusion coefficient molecules as well H-bond lifetimes calculated liquid compared to bulk values. It is found that have a non-negligible component along normal, although this limited in 7–15 ps, value comparable with time. also seen interfacial move considerably faster, their H-bonds live shorter, than phase. This...
Study of antitumor activity mono- and bis-quinoline based (thio)carbohydrazones on THP-1 AsPC-1 cancer stem cells, revealed that thiocarbohydrazones had superior pro-apoptotic than carbohydrazones with multi-target profile activities.
Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended use in human therapy require specific knowledge about the chemistry and biological activities. In this study, ethanol–water extracts were prepared by maceration microwave- ultrasound-assisted extractions (MAE UAE, respectively) order to obtain bioactive molecules from Paeonia tenuifolia L., peregrina Mill., officinalis L. wild growing...
Abstract Due to the rise of microbial strains resistant conventional therapies, there is an urgent need for finding new antimicrobial chemotypes. Heterocyclic compounds such as thiocarbohydrazones (TCHs) are able interact with many metalloenzymes essential microbes, while sulfur atom increases lipophilicity which generally positively correlated potency. In this paper, we report antibacterial and antifungal activity twenty‐two TCHs toward eight bacterial three fungal strains. Furthermore,...