A5020941403- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Organometallic Compounds Synthesis and Characterization
- Prostate Cancer Diagnosis and Treatment
- Magnetism in coordination complexes
- Free Radicals and Antioxidants
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Organoselenium and organotellurium chemistry
- vaccines and immunoinformatics approaches
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Lanthanide and Transition Metal Complexes
- Synthesis of Tetrazole Derivatives
- Metal-Organic Frameworks: Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
Artistic Realization Technologies
2023-2025
University of Belgrade
2015-2024
University of Belgrade – Faculty of Chemistry
2015-2023
Coherus BioSciences (United States)
2020-2021
Highland Hospital
2016-2021
Alameda Health System
2016-2018
Faculty (United Kingdom)
2017
Decipher (Decipher Biosciences Inc) is a genomic classifier (GC) developed to estimate the risk of distant metastasis (DM) after radical prostatectomy (RP) in patients with prostate cancer.To validate GC context randomized phase 3 trial.This ancillary study used RP specimens from placebo-controlled NRG/RTOG 9601 clinical trial conducted March 1998 2003. The were centrally reviewed, and RNA was extracted highest-grade tumor available 2019 median follow-up 13 years. Clinical-grade whole...
PURPOSE The SPARTAN trial demonstrated that the addition of apalutamide to androgen deprivation therapy improves outcomes among patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). We applied a previously reported digital histopathology–based multimodal artificial intelligence (MMAI) algorithm estimate clinical in SPARTAN. METHODS Patients available hematoxylin and eosin-stained slides from primary tumor were included. Histopathology digitized. MMAI scores ranging 0 1...
Abstract Purpose Oligometastatic castration-sensitive prostate cancer (omCSPC) is a clinically and biologically heterogeneous disease. A multimodal artificial intelligence (MMAI) algorithm (ArteraAI Prostate Test), which incorporates digital histopathology clinical information, prognostic for outcomes in localized cancer. We hypothesized MMAI algorithms are also omCSPC correlate with tumor biology. Thus, we aimed to evaluate the association between score vector features (VF) genomics of...
364 Background: Over the past decade, multiple biomarkers have been developed and validated to improve precision of prostate cancer prognosis estimation. However, these require access archival tissue central laboratory processing for RNA extraction, as a result are labor-intensive expensive. Deep learning models based on image analysis standard clinical pathology slides may offer similar accuracy with much improved lower cost. Multimodal artificial intelligence (MMAI) (Artera, Los Altos, CA)...
Background.Urban emergency departments (EDs) seem to be able detect new hepatitis C virus (HCV) infections at a high rate, but it is unknown the extent which individuals screened in ED can progress treatment and cure. We evaluate HCV Continuum of Care for patients identified with 2 urban EDs, consider results context outcomes from ambulatory screening venues where 2%–10% chronically infected are treated.
The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to pathogenesis cancer disorders, potential drug candidates should possess good antioxidant properties. Due promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, focused library 12 benzylidene-based...
Pseudomonas aeruginosa is one of the most dreaded human pathogens, because its intrinsic resistance to a number commonly used antibiotics and ability form sessile communities (biofilms). Innovative treatment strategies are required that can rely on attenuation pathogenicity virulence traits. The interruption mechanisms intercellular communication in bacteria (quorum sensing) such promising strategies. A cobalt coordination compound (Co(HL)₂) synthesized from...
<h3>Importance</h3> The National HIV Strategic Plan for the US recommends screening in emergency departments (EDs). most effective approach to ED-based remains unknown. <h3>Objective</h3> To compare strategies when integrated into usual ED practice. <h3>Design, Setting, and Participants</h3> This randomized clinical trial included patients visiting EDs at 4 urban hospitals between April 2014 January 2016. Patients were ages 16 years or older, not critically ill mentally altered, known have...
Abstract In the current pandemic, finding an effective drug to prevent or treat infection is highest priority. A rapid and safe approach counteract COVID‐19 in silico repurposing. The SARS‐CoV‐2 PLpro promotes viral replication modulates host immune system, resulting inhibition of antiviral innate response, therefore attractive target. this study, we used a combined virtual screening for candidates protease inhibitors. We Informational spectrum method applied Small Molecules searching...
A new Zn(<sc>ii</sc>)-based complex shows a concentration-dependent apoptotic response in highly resistant pancreatic adenocarcinoma cells with extensive activation of caspase-8 and -9.
Se-based complexes showed potent biological activity and lower toxicity in comparison to their sulphur analogues.
The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes Zn(II), Cd(II) Ni(II) were published previously. Here we report first evidence on anti-proliferative activity molecular patterns that underlie it. corresponding ligand are shown to be cytotoxic panel nine, malignant non-malignant cell lines, with exception complex did not achieve IC50 value any lines tested. Further experiments selected including A 549, MRC-5, EA.hy 926...
Our previous studies showed that zinc (II), cadmium (II) and nickel complexes with 2-formylpyridine selenosemicarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity MMP-2/9 human breast MDA-MB-361 cells. As shown by vitro transmembrane assays, complex was most...
Study of antitumor activity mono- and bis-quinoline based (thio)carbohydrazones on THP-1 AsPC-1 cancer stem cells, revealed that thiocarbohydrazones had superior pro-apoptotic than carbohydrazones with multi-target profile activities.