A5015475982- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Bone fractures and treatments
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods in Clinical Trials
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Cancer survivorship and care
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Metastases and Treatment
WellSpan Health
2013-2025
B.P. Koirala Institute of Health Sciences
2020-2022
Thomas Jefferson University Hospital
2019-2021
WellSpan York Hospital
2019
Baylor Scott & White Health
2016
Duke University
2016
Kaiser Permanente
2016
Cedars-Sinai Medical Center
2016
Creative Commons
2014
Sir Sayajirao General Hospital Medical College
2014
Purpose Conventional radiotherapy (C-RT) treatment schedules for patients with prostate cancer typically require 40 to 45 treatments that take place from > 8 9 weeks. Preclinical and clinical research suggest hypofractionation—fewer but at a higher dose per treatment—may produce similar outcomes. This trial was designed assess whether the efficacy of hypofractionated (H-RT) schedule is no worse than C-RT in men low-risk cancer. Patients Methods A total 1,115 were randomly assigned 1:1...
Decipher (Decipher Biosciences Inc) is a genomic classifier (GC) developed to estimate the risk of distant metastasis (DM) after radical prostatectomy (RP) in patients with prostate cancer.To validate GC context randomized phase 3 trial.This ancillary study used RP specimens from placebo-controlled NRG/RTOG 9601 clinical trial conducted March 1998 2003. The were centrally reviewed, and RNA was extracted highest-grade tumor available 2019 median follow-up 13 years. Clinical-grade whole...
JCO
PURPOSE To determine the impact of treatment toxicity on long-term survival in pediatric Hodgkin's disease. PATIENTS AND METHODS We studied late events 387 patients treated for disease four consecutive clinical trials at St Jude Children's Research Hospital from 1968 to 1990. Relative risks, actuarial and absolute excess risks cause-specific deaths were calculated. RESULTS As April 1997, 316 (82%) alive, with a median follow-up 15.1 (range, 2.9 28.6) years. In this cohort, which represented...
Abstract Akt, a Serine/Threonine protein kinase, mediates growth factor–associated cell survival. Constitutive activation of Akt (phosphorylated P-Akt) has been observed in several human cancers, including lung cancer and may be associated with poor prognosis chemotherapy radiotherapy resistance. The clinical relevance P-Akt non–small (NSCLC) is not well described. In the present study, we examined 82 surgically resected snap-frozen paraffin-embedded stage I to IIIA NSCLC samples for by...
Hypofractionated radiotherapy (HRT) would be more convenient for men with low-risk prostate cancer and cost less than conventional (CRT) as long HRT is noninferior to CRT in terms of survival quality life (QOL) not found worse.To assess differences QOL between who are treated vs CRT.In this phase 3 randomized clinical trial, were enrolled from sites within the National Cancer Institute's Clinical Trials Network United States, Canada, Switzerland.Random assignment (73.8 Gy 41 fractions over...
1 Background: To determine whether the efficacy of a hypofractionated (H) schedule is no worse than conventional (C) in men with low-risk prostate cancer. Methods: From April 2006 to December 2009, one thousand hundred fifteen cancer (clinical stage T1-2a, Gleason ≤ 6, PSA < 10) were randomly assigned 1:1 (73.8 Gy 41 fractions over 8.2 weeks) or (70 28 5.6 weeks). The trial was designed establish 90% power and alpha = 0.05 that results 5-year disease-free survival (DFS) not lower by more...
384 Background: RTOG 0521 was a randomized trial of radiotherapy (RT) and 24 months androgen deprivation (ADT) with without docetaxel (D) in high risk prostate cancer. We sought to evaluate whether post RT PSA prognostic outcomes predictive the benefit D. hypothesized that patients higher derive from D while those lower would no benefit. Methods: Patients treated on received 72-75.6 Gy 40-42 fractions 8 weeks after starting ADT. In experimental arm, started 28 days RT. Per protocol, be drawn...
Background: Total hip arthroplasty (THA) and total knee (TKA) are effective treatments for advanced osteoarthritis (OA) other joint disorders. Despite their efficacy, many patients experience residual functional limitations postoperatively. This study evaluates outcomes following unilateral THA TKA, integrating patient-reported outcome measures (PROMs) performance-based (PBOMs) over 12 weeks. Methods: prospective observational study, conducted at B. P. Koirala Institute of Health Sciences,...
The most common secondary neoplasms which occur following cranial radiation therapy are sarcoma and meningioma. occurrence of glioblastoma multiforme chemotherapy in acute lymphocytic leukaemia (ALL) is rare. We report 3 cases children developing 11–72 months completion chemotherapy/radiotherapy for ALL. exact cause the development ALL not clear. A genetic predisposition may be essential such a highly malignant primary brain tumour patients, irrespective and/or chemotherapy. pathogenesis...
Background: Intramedullary fixation is biomechanically superior to extramedullary for fracture of peritrochanteric region femur in elderly which often complicated due associated osteoporosis. Helical blade proximal femoral nail antirotation II has stronger purchase the head preventing rotation and cutout. This study was done evaluate outcome Proximal Femoral Nail Antirotation B.P. Koirala Institute Health Sciences.Methods: Retrospective review data 100 traumatic cases operated between March...