A5044903935- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Effects of Radiation Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Women's cancer prevention and management
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Radiation Therapy and Dosimetry
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- Global Cancer Incidence and Screening
University of Hawaiʻi at Mānoa
2025
McGill University Health Centre
2015-2024
McGill University
2012-2024
Pontifícia Universidade Católica de Campinas
1997-2023
Centro de Pesquisas Oncológicas
1985-2023
Concordia University
2021
Software (Spain)
2019
Algebra University College
2019
Bavarian Research Institute for Digital Transformation
2019
University of Zagreb
2018
Purpose Conventional radiotherapy (C-RT) treatment schedules for patients with prostate cancer typically require 40 to 45 treatments that take place from > 8 9 weeks. Preclinical and clinical research suggest hypofractionation—fewer but at a higher dose per treatment—may produce similar outcomes. This trial was designed assess whether the efficacy of hypofractionated (H-RT) schedule is no worse than C-RT in men low-risk cancer. Patients Methods A total 1,115 were randomly assigned 1:1...
IntroductionThe use of stereotactic body radiotherapy (SBRT) for tumors in close proximity to the central mediastinal structures has been associated with a high risk toxicity. This study (BLINDED FOR REVIEW) aimed determine maximally tolerated dose (MTD) SBRT ultra-central (UC) non-small cell lung carcinoma (NSCLC), using time-to-event continual reassessment methodology (TITE-CRM).MethodsPatients T1-3N0M0 (≤ 6 cm) NSCLC were eligible. The MTD was defined as ≤ 30% rate grade (G) 3-5...
JCO
PURPOSE NRG-RTOG0617 demonstrated a detrimental effect of uniform high-dose radiation in stage III non–small cell lung cancer. NRG-RTOG1106/ECOG-ACRIN6697 (ClinicalTrials.gov identifier: NCT01507428 ), randomized phase II trial, studied whether midtreatment 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can guide individualized/adaptive dose-intensified radiotherapy (RT) to improve and predict outcomes patients with this disease. MATERIALS AND METHODS...
BackgroundA multi-institutional phase II trial was performed to assess a hypofractionated accelerated radiotherapy regimen for early stage non–small cell lung cancer (NSCLC) in an era when stereotactic body not widely available.
Stereotactic body radiotherapy (SBRT) is widely used for stage I medically inoperable non-small cell lung cancer (NSCLC), yet varied results from randomized clinical trials (RCTs) and concerns in treating centrally located tumors persist.
Purpose: Prediction of radiation pneumonitis (RP) has been shown to be challenging due the involvement a variety factors including dose–volume metrics and radiosensitivity biomarkers. Some these are highly correlated might affect prediction results when combined. Bayesian network (BN) provides probabilistic framework represent variable dependencies in directed acyclic graph. The aim this study is integrate BN systems’ biology approach detect possible interactions among RP risk exploit...
1 Background: To determine whether the efficacy of a hypofractionated (H) schedule is no worse than conventional (C) in men with low-risk prostate cancer. Methods: From April 2006 to December 2009, one thousand hundred fifteen cancer (clinical stage T1-2a, Gleason ≤ 6, PSA < 10) were randomly assigned 1:1 (73.8 Gy 41 fractions over 8.2 weeks) or (70 28 5.6 weeks). The trial was designed establish 90% power and alpha = 0.05 that results 5-year disease-free survival (DFS) not lower by more...
8548 Background: NRG-RTOG 0617 (R0617) found that non-personalized dose escalation of radiotherapy (RT) with concurrent chemotherapy was deleterious. 1106/ACRIN 6697 (R1106) studied adaptive chemoradiotherapy, using tumor and patient individualized RT intensification simultaneously field reduction, based upon mid-treatment FDG-PET. Methods: The control arms both studies used 60 Gy (+ weekly carboplatin/paclitaxel). investigational arm R0617 74 in 37 fractions, no field/dose adaptation, while...
A prospective phase II study to investigate the feasibility and rate of complete pathological response (ypT0) after short-course radiotherapy (SCRT) followed by surgery at 8 weeks.Operable patients with localized rectal cancer staged T3-4N0/+ or T2N+ were eligible received 25 Gy (in one-third patients, gross tumor volume a simultaneous integrated boost up total 30 Gy) in five consecutive fractions posterior pelvis weeks later. Pathological surgical toxicity assessed all patients.Fifty-two...
We report the genome sequence of phage Sourignavong isolated from soil in Oklahoma City, using Arthrobacter sp. ATCC 21022. The 15,625 bp contains 27 predicted protein coding genes, including two endolysin enzyme genes. is assigned to actinobacteriophage cluster AN.
PURPOSE Artificial intelligence (AI) tools could improve clinical decision making or exacerbate inequities because of bias. African American (AA) men reportedly have a worse prognosis for prostate cancer (PCa) and are underrepresented in the development genomic biomarkers. We assess generalizability developed using multimodal AI (MMAI) deep learning system digital histopathology data from NRG/Radiation Therapy Oncology Group PCa trials across racial subgroups. METHODS In total, 5,708...
Inter‐patient radiation sensitivity variability has recently been shown to have a genetic component. This component may play key role in explaining the fluctuating rates of radiation‐induced toxicities (RITs). Single nucleotide polymorphisms (SNPs) thus far yielded inconsistent results delineating RITs while copy number variations (CNVs) not yet investigated for such purposes. We explore radiogenomic modeling approach investigate association CNVs and SNPs, along with clinical dosimetric...