A5038106718- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Steroid Chemistry and Biochemistry
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cholesterol and Lipid Metabolism
- Stoma care and complications
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- Probiotics and Fermented Foods
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Bariatric Surgery and Outcomes
Centre Hospitalier de l’Université de Montréal
2005-2025
Université de Montréal
2008-2025
McGill University Health Centre
2019
Hôpital Saint-Luc
2004-2018
Jewish Hospital
2003-2004
Barnes-Jewish Hospital
2003-2004
Centre Hospitalier Universitaire Sainte-Justine
2001
Fibrin glue has been used to treat anal fistulas in an attempt avoid more radical surgical intervention. Reported success rates vary widely. The purpose of this study was review the use fibrin management complex at a tertiary referral center.This designed as retrospective all patients treated with injection for Section Colon and Rectal Surgery, Washington University School Medicine/Barnes-Jewish Hospital. Demographics, previous treatment, operative information, early follow-up were obtained...
PURPOSE: Pseudomyxoma peritonei is a rare disease. Recently, cytoreductive surgery with intraperitoneal hyperthermic chemotherapy has emerged as promising treatment for this debilitating condition. The aim of prospective study was to evaluate strategy. METHOD: Twenty-seven patients pseudomyxoma who were treated by and chemohyperthermia between 1997 2003 identified from database. RESULTS: Clinical presentation included suspected appendicitis (33 percent), increased abdominal girth (30 ovarian...
The drug targets IL23 and IL12 regulate pathogenicity plasticity of intestinal Th17 cells in Crohn's disease (CD) ulcerative colitis (UC), the two most common inflammatory bowel diseases (IBD). However, studies examining dysregulation mesenteric lymph nodes (mLNs) these patients are rare. We showed that mLNs, CD could be distinguished from UC by increased frequencies CCR6+CXCR3-ROR+Tbet-CD4+ (Th17) memory T enriched CD62Llow effector (TEM), their differentially expressed molecular profile....
Colorectal cancer (CRC) is the third most diagnosed and second common cause of deaths worldwide. CRC patients present with an increase in pathogens their gut microbiota, such as polyketide synthase-positive bacteria (pks +) enterotoxigenic Bacteroides fragilis (ETBF). The pks + Escherichia coli promotes carcinogenesis facilitates progression through production colibactin, a genotoxin that induces double-strand DNA breaks (DSBs). ETBF procarcinogenic bacterium producing B. toxin (bft)...
<p>Figure S1 shows E. coli metabolome and ornithine decarboxylase activity</p>
<p>Figure S3 shows the effect of putrescine on gut microbiota</p>
<p>Figure S4 shows gut microbiota changes after DSS-induced flares</p>
<p>Figure S2 shows the effects of putrescine supplementation on cell proliferation</p>
<p>Table S2 shows primers used</p>
<p>Table S1 shows cohort characteristics</p>
<p>Figure S5 shows the effect of putrescine on gut microbiota functions</p>
<p>Figure S6 shows growth of pks+ E. coli strains isolated from human samples</p>
<p>Figure S7. Putrescine lowers inflammation, inhibits pks+ E. coli growth, and reduces tumor development.</p>
Abstract Background Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While supplementation routinely used to manage anemia in CRC patients, it may also impact promote tumorigenesis. In this study, we investigated the of initial composition on iron-promoted We performed fecal transplantation (FMT) Apc Min/ + mice using samples from healthy controls, mice, followed exposure sufficient or excess diets. Results found that promoted resulted distinct...
PURPOSE: This study was undertaken to determine the risks of cancer in unresectable polyps and compare short-term outcome laparoscopic colectomy with that open for benign polyps. METHODS: A retrospective review all patients (n = 165) undergoing an adenoma at colonoscopy performed on collected a prospective database. One hundred four underwent 61 between 1991 2003. Follow-up 7 155 (median, 90) months. RESULTS: In group, 85% right 15% left or sigmoidectomy. Conversion occurred 4.8% cases....
Abstract Purpose: Anastomotic leak (AL) is a major complication in colorectal cancer surgery and consists of the leakage intestinal content through poorly healed colonic wound. Colorectal recurrence after determinant survival. We hypothesize that AL may allow cells to escape gut lead improving anastomotic healing prevent local implantation metastatic dissemination cells. Experimental Design: investigated association between postoperative outcomes patients with cancer. Using mouse models poor...
Abstract Background Fluoropyrimidines are used in chemotherapy combinations for multiple cancers. Deficient dihydropyrimidine dehydrogenase activity can lead to severe life-threatening toxicities. DPYD*2A polymorphism is one of the most studied variants. The study objective was document impact implementing this test routine clinical practice. Methods We retrospectively performed chart reviews all patients who tested positive a heterozygous or homozygous mutation samples obtained from...
Aggressive pelvic angiomyxoma is a very rare mesenchymal tumor that usually diagnosed in premenopausal female patients. The current mainly reported treatment wide surgical excision. Other options, such as radiotherapy and hormonal therapy, have been suggested potential alternatives. A 61-year-old postmenopausal patient presented with hematuria led to the identification of perirectal mass on abdominopelvic imaging. 46-year-old perineal unknown etiology. Despite extensive investigations,...
Abstract Background and Objectives EUS is a potential alternative for the drainage of abscesses. The aim this study was to determine if EUS-guided pelvic abscess technically feasible, safe, valid option resolution. Methods We conducted retrospective review from 2002 2020 at single quaternary institution. EUS–guided via transrectal route performed in all patients with or without drain/stent placement. Technical clinical success analyzed. Descriptive analyses Fisher exact test were performed....
<div>AbstractPurpose:<p>Anastomotic leak (AL) is a major complication in colorectal cancer surgery and consists of the leakage intestinal content through poorly healed colonic wound. Colorectal recurrence after determinant survival. We hypothesize that AL may allow cells to escape gut lead improving anastomotic healing prevent local implantation metastatic dissemination cells.</p>Experimental Design:<p>We investigated association between postoperative outcomes...
367 Background: FOLFIRINOX has emerged as a new standard for patients with performance status ECOG 0-1 in metastatic pancreatic cancer and non-randomized studies also support this regimen locally advanced disease. This is however associated significant toxicity. The purpose of study was to assess efficacy toxicity outside clinical trial, including community hospitals. Methods: We conducted retrospective adenocarcinoma who received between January 2011 June 2013 six institutions the province...