A5078104586- Prenatal Substance Exposure Effects
- Substance Abuse Treatment and Outcomes
- Homelessness and Social Issues
- Gestational Diabetes Research and Management
- Alcohol Consumption and Health Effects
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Maternal Mental Health During Pregnancy and Postpartum
- Opioid Use Disorder Treatment
- Trauma and Emergency Care Studies
- Mental Health Treatment and Access
- Cancer survivorship and care
- Emergency and Acute Care Studies
- Child and Adolescent Psychosocial and Emotional Development
- Cardiac Arrest and Resuscitation
- Schizophrenia research and treatment
- Pelvic and Acetabular Injuries
- Birth, Development, and Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vitamin D Research Studies
- Epigenetics and DNA Methylation
- Pain Management and Opioid Use
- Environmental Justice and Health Disparities
- Healthcare Decision-Making and Restraints
- Health disparities and outcomes
Harvard University
2016-2025
VA Boston Healthcare System
2016-2025
Mount Sinai Hospital
2019-2024
University of Kentucky
2023-2024
Lancaster General Hospital
2023-2024
Massachusetts General Hospital
2007-2024
University of Arizona
2023-2024
Temple University Hospital
2023-2024
Medical College of Wisconsin
2023-2024
University of California, Irvine Medical Center
2023-2024
• Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating naltrexone and two manual guided psychotherapies the treatment of alcohol dependence. Patients randomized to receive either or placebo coping skills/relapse prevention therapy supportive designed support patient's own efforts at abstinence without teaching specific skills. Naltrexone proved superior measures drinking alcohol-related problems, including abstention rates,...
<h3>Objective</h3> To determine the accuracy of CRAFFT substance abuse screening test. <h3>Design</h3> Criterion standard validation study comparing score on 6-item test with categories determined by a concurrently administered substance-use problem scale and structured psychiatric diagnostic interview. Screening were "any problem" (ie, use, abuse, or dependence), disorder" "dependence." <h3>Setting</h3> A large, hospital-based adolescent clinic. <h3>Participants</h3> Patients aged 14 to 18...
Background: Adolescents should be screened for alcohol misuse as part of routine care. The objective this study was to compare the criterion validity Alcohol Use Disorders Identification Test (AUDIT), Problem Oriented Screening Instrument Teenagers substance use/abuse scale (POSIT), and CAGE CRAFFT questions among adolescents. Methods: Fourteen‐ 18‐year‐old patients arriving healthcare at a large, hospital‐based adolescent clinic completed four screens standard Adolescent Diagnostic...
To test the effectiveness of a brief intervention in reduction prenatal alcohol consumption by women when partner is included.Randomized trial single session given study nurse or principal investigator for 304 pregnant and their partners. The had positive T-ACE (Tolerance, Annoyed, Cut down, Eye-opener, an screening test) results were at risk while pregnant. All completed initial diagnostic postpartum interviews.Fewer than 20% participants (median 11.5 weeks gestation) abstinent enrollment,...
Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there few long-term, high-dose large-scale trials.To test the effects vitamin D3 supplementation on late-life and mood scores.There were 18 353 men women aged 50 years or older VITAL-DEP (Vitamin Omega-3 Trial-Depression Endpoint Prevention) ancillary study to VITAL, a randomized clinical trial cardiovascular disease cancer prevention among 25 871 adults US. There 16 657 at incident (ie,...
Drs. McCaul, Roach, Hasin, Weisner, and Chang have no conflicts of interest to declare. Dr. Sinha is a member the Scientific Advisory Board Embera Neurotherapeutics, Inc.
<h3>Importance</h3> Marine omega-3 fatty acid (omega-3) supplements have been used to treat depression but their ability prevent in the general adult population is unknown. <h3>Objective</h3> To test effects of supplementation on late-life risk and mood scores. <h3>Design, Setting, Participants</h3> A total 18 353 adults participated VITAL-DEP (Vitamin D Omega-3 Trial-Depression Endpoint Prevention) ancillary study VITAL, a randomized trial cardiovascular disease cancer prevention among 25...
Aims . To assess the impact of a brief intervention on antepartum alcohol consumption. Design. A randomized clinical trial. Setting. The obstetrics practices Brigham and Women's Hospital in Boston, MA, USA. Participants. Two hundred fifty eligible women initiating prenatal care. Intervention. comprehensive assessment use (assessment only, AO) or same with (BI). Measurement. Demographic background obstetric history subjects, current lifetime substances, composite Addiction Severity Index...
Alcohol-dependent patients (N = 97) were randomly assigned to receive either naltrexone or placebo and relapse prevention therapy supportive therapy. The present report explored the hypothesis that could be matched above treatments on basis of specific pretreatment characteristics. Treatment matching variables included craving, alcohol dependence severity, cognitive measures learning memory. Results linear regression analyses tentatively suggest experiencing higher levels craving poorer...
<h3>Importance</h3> Knowledge gaps persist regarding racial and ethnic variation in late-life depression, including differences specific depressive symptoms disparities care. <h3>Objective</h3> To examine racial/ethnic depression severity, symptom burden, <h3>Design, Setting, Participants</h3> This cross-sectional study included 25 503 of 871 community-dwelling older adults who participated the Vitamin D Omega-3 Trial (VITAL), a randomized trial cancer cardiovascular disease prevention...
Although screening and brief intervention (SBI) for unhealthy alcohol use has demonstrated efficacy in some trials, its implementation been limited. Technology-delivered approaches are a promising alternative, particularly during pregnancy when the importance of is amplified. The present trial evaluated feasibility acceptability an interactive, empathic, video-enhanced, computer-delivered SBI (e-SBI) plus 3 tailored mailings, estimated effects. We recruited 48 pregnant women who screened...