A5011440784- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Neuropeptides and Animal Physiology
- Orthopedic Infections and Treatments
- Radioactive element chemistry and processing
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- Chemical Reactions and Isotopes
- Radiation Therapy and Dosimetry
- Cholinesterase and Neurodegenerative Diseases
- Lung Cancer Treatments and Mutations
- Phytochemicals and Antioxidant Activities
- Chronic Lymphocytic Leukemia Research
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Neuroendocrine Tumor Research Advances
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Neonatal Respiratory Health Research
- Ear and Head Tumors
Instytut Chemii i Techniki Jądrowej
2014-2024
University of Coimbra
2006-2008
University of Warsaw
2005
Délégation Centre-Est
1994-1996
The use of conventional methods for the treatment cancer, such as chemotherapy or radiotherapy, and approaches brachytherapy in conjunction with unique properties nanoparticles could enable development novel theranostic agents. aim our current study was to evaluate potential iron oxide nanoparticles, coated alginic acid polyethylene glycol, functionalized chemotherapeutic agent doxorubicin monoclonal antibody bevacizumab, serve a nanoradiopharmaceutical against breast cancer. Direct...
Gold nanoparticles labeled with <sup>211</sup>At are very effective in radionuclide therapy.
Auger electrons are low-energy, high-linear-energy-transfer particles that deposit their energy over nanometers distances. Their biological impact depends heavily on where the radionuclide is localized within cell. To verify hypothesis cell membrane may be a better molecular target than cytoplasm in electron therapy, we investigated whether radiotoxicity of 99mTc varied depending its location The behavior peptide radiopharmaceuticals 99mTc-TECANT targeted was compared with 99mTc-TEKTROTYD...
Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far, radiopharmaceuticals used in this approach have been based on endogenous agonist NK1R, Substance P or its close analogues. Herein, we well-known, small molecular NK1R antagonist, L732,138, as basis radiopharmaceutical vector. First, 14 analogues compound were evaluated to check whether extending parent structure with linkers different...
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research, we developed two novel structural modifications aprepitant create conjugates with different radionuclide chelators. All them were radiolabeled 68Ga 177Lu radionuclides evaluated in terms their lipophilicity stability human serum. Furthermore,...
The 99mTc-labeled conjugates of the vasopressin (AVP) peptide and its analogue d(CH2)5[D-Tyr(Et2)-Ile4-Eda9]AVP (AVP(an)) have been synthesized using technetium complexes with tetradentate tripodal chelator (the tris(2-mercaptoethyl)amine (NS3)) monodentate isocyanide ligand (CN-peptide). exhibit high stability in presence 100 times molar excess standard amino acids cysteine or histidine also satisfactory human serum. 99mTc(NS3)(CN-AVP) 99mTc(NS3)(CN-AVP(an)) ability binding to small-cell...
Gliomas, particularly WHO grade IV glioblastoma multiforme, are one of the most common and aggressive primary tumors central nervous system. The neuropeptide, substance P (SP), is physiological ligand neurokinin-1 (NK-1) receptor that consistently overexpressed in cells. aim this work was to study physico-chemical biological properties different SP analogues labeled with technetium-99m lutetium-177 radionuclides. synthesized compounds were characterized vitro by partition coefficients (logP)...
Abstract Anthocyanin compounds, cyanin, peonidin, myrtillin, malvin, kuromanin, oenin, petunidin and pelargonidin, present in four varieties of red grape skin extracts were quantified by reversed‐phase high‐performance liquid chromatography with electrochemical detection (RP‐HPLC‐ED). Several extraction procedures evaluated for anthocyanin from skins the Dão wine demarcated region Portugal. The developed method was successfully applied to analysis anthocyanins grapes during 2005 harvest...
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on structure of small molecular antagonists neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation aprepitant-based 177Lu-radioconjugates in terms future oncological applications. For purpose, three novel aprepitant homologues were synthesized to broaden previously obtained derivative portfolio, functionalized with DOTA chelator and labeled 68Ga 177Lu. The newly...