A5056791135- Nanoparticles: synthesis and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiopharmaceutical Chemistry and Applications
- Crystallography and molecular interactions
- Graphene and Nanomaterials Applications
- Boron Compounds in Chemistry
- Heavy Metal Exposure and Toxicity
- Radiation Therapy and Dosimetry
- Air Quality and Health Impacts
- Nanoparticle-Based Drug Delivery
- Effects and risks of endocrine disrupting chemicals
- Anesthesia and Neurotoxicity Research
- Radiation Effects and Dosimetry
- Metal complexes synthesis and properties
- Neuroinflammation and Neurodegeneration Mechanisms
- Iron Metabolism and Disorders
- Metalloenzymes and iron-sulfur proteins
- Healthcare and Environmental Waste Management
- Per- and polyfluoroalkyl substances research
- Pharmaceutical and Antibiotic Environmental Impacts
- Carcinogens and Genotoxicity Assessment
- Electrospun Nanofibers in Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Medical Imaging Techniques and Applications
Instytut Chemii i Techniki Jądrowej
2011-2024
National Centre for Nuclear Research
2024
University of Warsaw
2024
National Institute of Public Health
2024
Instytut Medycyny Wsi im. Witolda Chodźki
2024
Jan Kochanowski University
2024
Abstract Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry medicine. Therefore, for many years a growing interest has been observed among the scientific community improvement our understanding impact on living organisms, especially humans. Considering delicate structure central nervous systemit is one organs most vulnerable adverse effects metallic nanoparticles. For that reason, it...
Seven derivatives of plant-derived hydroxybenzoic acid (HBA)—including 2,3-dihydroxybenzoic (2,3-DHB, pyrocatechuic), 2,4-dihydroxybenzoic (2,4-DHB, β-resorcylic), 2,5-dihydroxybenzoic (2,5-DHB, gentisic), 2,6-dihydroxybenzoic (2,6-DHB, γ-resorcylic acid), 3,4-dihydroxybenzoic (3,4-DHB, protocatechuic), 3,5-dihydroxybenzoic (3,5-DHB, α-resorcylic), and 3,4,5-trihydroxybenzoic (3,4,5-THB, gallic) acids—were studied for their structural biological properties. Anti-/pro-oxidant properties were...
Recently, we showed that silver nanoparticles (AgNPs) caused apoptosis, necrosis and DNA strand breaks in different cell models vitro. These findings warranted analyses of their relevance vivo. We investigated the genotoxic potential gene expression profiles particles nano- (Ag20, 20 nm) submicron- (Ag200, 200 size titanium dioxide (TiO2-NPs, 21 selected tissues from exposed male mice including gonades. A single dose 5 mg/kg bw was administered intravenously to derived C57BL6 (WT)...
Gold nanoparticles labeled with <sup>211</sup>At are very effective in radionuclide therapy.
The 225Ac radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately, the major challenge radioconjugates labelled with is that traditional chelating moieties are unable to sequester radioactive daughters bioconjugate which critical minimize toxicity healthy, non-targeted tissues. In present work, we propose apply TiO2 nanoparticles (NPs) as carrier and its decay products. surface of 25 nm diameter was modified Substance P (5-11), a...
The radiolytic methods of PFOS decomposition in aqueous solutions investigated this work for potential environmental applications are based on the use gamma rays or a beam accelerated electrons (EB) under different chemical conditions irradiated solutions. most active reagents employed hydrated from water radiolysis. There also OH and H radicals which take part occurring reactions. In presence formate 2-propanol solutions, reductive derived them (CO2−, (CH2)2C-OH) able to induce PFOS. turn,...
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction results in generation superoxide anion radical (O2•-), which due the relatively low chemical reactivity rather unlikely cause harmful effects triggered by nanoparticles. We show that treatment HepG2 cells with silver nanoparticles (AgNPs) resulted H2O2 instead O2•-, as measured specific mitochondrial probes. Moreover, addition selective iron chelator diminished...
Diseases of periodontal tissues are a considerable clinical problem, connected with inflammatory processes and bone loss. The healing process often requires reconstruction lost in the area. For that purpose, various membranes used to prevent ingrowth epithelium tissue defect enhance regeneration. Currently-used mainly non-resorbable or derived from animal tissues. Thus, there is an urgent need for non-animal-derived bioresorbable tuned resorption rates porosity optimized circulation body...
Epidemiological data indicate that exposure to diesel exhaust particles (DEPs) from traffic emissions is associated with higher risk of morbidity and mortality related cardiovascular pulmonary diseases, accelerated progression atherosclerotic plaques, possible lung cancer. While the impact DEPs combustion fossil fuel on human health has been extensively studied, current knowledge biofuels provides limited inconsistent information about its mutagenicity genotoxicity, as well adverse risks....
The increasing body of evidence suggest that nanomaterials toxicity is associated with generation oxidative stress. In this paper we investigated the role respiration in silver nanoparticles (AgNPs) generated stress and toxicity. Since cancer cells rely on glucose as main source energy supply, availability might be an important determinant NPs AgNPs 20 nm nominal diameter were used a model NPs. HepG2 cultured media high (25 mM) or low (5.5 content treated AgNPs. AgNPs-induced was tested by...
Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials due to their antibacterial properties. Owing recent boost in usage AgNPs-containing products, human exposure AgNPs is increasing, highlighting need for careful evaluation toxicity humans. We two cellular models, hepatic HepG2 and epithelial A549 cell lines, study mechanism AgNPs-induced at level. These lines differ significantly response treatment. In case cells, a minor decrease viability increase extent DNA breakage...
Extensive use of zeolite nanoparticles in many areas, including medicine, has led to the concern about an impact and possible risk their for human health environment.In our studies, we investigated uptake, retention, cytotoxicity nanozeolite A (BaA) functionalized with aminopropyl or poly(ethylene glycol) (PEG) different chain lengths using cervical carcinoma cell line. For internalization was labeled (133)Ba radionuclide.The results show that case PEG modification, toxicity uptake depend on...
Modification of ultrasmall gold nanoparticles (AuNPs) with the lipoic acid derivative folic was found to enhance their accumulation in cancer cell, as compared AuNPs without addressing units. The application enabled control nanoparticle functionalities leading enhanced solubility and allowing for attachment both cytotoxic drug, doxorubicin. More robust doxorubicin through amide bond resulted toxicity comparable that drug alone, opening a new perspective designing more potent, but less toxic...
Due to their potent antibacterial properties, silver nanoparticles (AgNPs) are widely used in industry and medicine. However, they can cross the brain–blood barrier, posing a risk brain its functions. In our previous study, we demonstrated that oral administration of bovine serum albumin (BSA)-coated AgNPs caused an impairment spatial memory dose-independent manner. this evaluated effects coating material on cognition, functioning, neurotransmitter levels rat hippocampus. coated with BSA...
Abstract We studied the effects of Aeroxide P25 titanium dioxide nanoparticles (TiO 2 NPs) with a diameter 21 nm on induction DNA damage and long-term survival three human cell lines: hepatocellular liver carcinoma HepG2, colorectal adenocarcinoma HT29 lung A549. The endpoints examined were breakage estimated by comet assay oxidative base recognized formamide-pyrimidine glycosylase (FPG) FPG + assay, frequencies histone γH2AX foci micronuclei, apoptosis, metabolic activity measured...
Alzheimer’s disease (AD) is a chronic neurodegenerative leading to progressive dementia in elderly people. The characterized, among others, by formation of amyloid- β (A β) polypeptide plaques the brain. Although etiology not fully understood, recent research suggest that nanomaterials may affect AD development. Here, we described consequences exposure mouse BV-2 microglia silver nanoparticles (AgNPs, 50 µg/mL), cerium oxide (CeO 2 NPs, 100 and cadmium telluride quantum dots (CdTeQDs, 3 or...
The fast-growing use of nanomaterials in everyday life raises the question about safety their use. Unfortunately, risks associated with nanoparticles (NPs) have not yet been fully assessed. majority studies conducted so far at molecular and cellular level focused on a single-type exposure, assuming that NPs act as only factor. In natural environment, however, we are likely exposed to mixture nanoparticles, whose interactions may modulate impact living organisms. This study aimed evaluate...
Perturbations in the transport of mitochondria and their quality control neuronal cells underlie many types neurological pathologies, whereas systems enabling convenient analysis behavior cellular models neurodegenerative diseases are limited. In this study, we present a modified version lund human mesencephalic cells, mitoLUHMES, expressing GFP mitochondrially targeted DsRed2 fluorescent proteins, intended for vitro trafficking by real-time fluorescence microscopy. This cell line can be...