A5006049641- Blood disorders and treatments
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Immunodeficiency and Autoimmune Disorders
- Estrogen and related hormone effects
- Trace Elements in Health
- Urticaria and Related Conditions
- Pharmacological Effects and Toxicity Studies
- Sulfur Compounds in Biology
- Neutropenia and Cancer Infections
- Erythrocyte Function and Pathophysiology
- Graphene and Nanomaterials Applications
- Adenosine and Purinergic Signaling
- Dental Implant Techniques and Outcomes
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
St. Jude Children's Research Hospital
2023-2024
Medical University of Lodz
2018-2023
Polish Academy of Sciences
2018-2023
Institute for Medical Biology
2018-2023
University of Łódź
2012-2015
The increasing body of evidence suggest that nanomaterials toxicity is associated with generation oxidative stress. In this paper we investigated the role respiration in silver nanoparticles (AgNPs) generated stress and toxicity. Since cancer cells rely on glucose as main source energy supply, availability might be an important determinant NPs AgNPs 20 nm nominal diameter were used a model NPs. HepG2 cultured media high (25 mM) or low (5.5 content treated AgNPs. AgNPs-induced was tested by...
The link between ERK1/2 activity and cisplatin cytotoxicity, in association with the cell cycle, ovarian cancer lines resistant (A2780cis; SK-OV-3) sensitive (A2780) to was determined. We observed that cisplatin, at a low concentration enhanced activation of A2780 cells increased their accumulation S phase, resulting cytotoxicity. A high drug induced dephosphorylation degradation extremely toxic, accumulating most these sub-G1 phase. PD98059, pharmacological inhibitor activation,...
Multidrug resistance (MDR), which is the main obstacle to cancer chemotherapy, mainly due overexpression of ATP-binding cassette (ABC) transporters, especially ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP). A novel idea overcome MDR that collateral sensitivity, i.e., finding a treatment cells overexpressing ABC transporters are more sensitive than do not overexpress them. In this study we demonstrate for first time MDCKII-BCRP cells, ABCG2, vulnerable exogenous oxidative stress...
The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from at various stages of progression are known to influence the pre-metastatic niche and metastatic potential. aim this study was analyze effect on murine colon adenocarcinoma (MC38 line) characteristics their EVs. Stable clones Snail-overexpressing MC38 were investigated in vitro versus Mock cells....
Adenosine released by cancer cells in high amounts the tumour microenvironment is one of main immunosuppressive agents responsible for escape from immunological control. Blocking adenosine receptors with analogues and restoring immune cell activity methods considered to increase effectiveness anticancer therapy. However, their direct effects on biology remain unclear. Here, we determined effect response cisplatinsensitive cisplatin-resistant ovarian cisplatin treatment.The PSB 36, DPCPX,...
Silver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage show potent anticancer both multidrug resistance (MDR) sensitive tumors. The MDR phenomenon, caused by the presence of ATP-binding cassette (ABC) proteins, is responsible for failure chemotherapy. Thus, investigating influence widely used on ABC...
During metastasis, cancer cells undergo phenotype changes in the epithelial-mesenchymal transition (EMT) process. Extracellular vesicles (EVs) released by are mediators of intercellular communication and play a role metastatic Knowledge factors that influence modifications pre-metastatic niche for migrating carcinoma is important prevention metastasis. We focus here on how progression affected EVs from either epithelial-like HT29-cells or early EMT stage triggered Snail transcription factor...
Background: Severe congenital neutropenia (SCN) is a rare haematological condition with heterogeneous genetic background that often leads to severe impairment of the immune system. For patients who do not respond standard treatment, only possible therapy allogeneic haematopoietic stem cell transplantation. SCN have an increased risk development myelodysplastic syndrome or acute myelogenous leukaemia. Rare disorders, such as SCN, require prioritising bone marrow failure diagnosis and tailored...
Additional file 1. Expression on mRNA level of all tested genes. Results are shown as fold change expression in cells sustained low glucose medium (5.5 mM) when compared with high (25 mM).
Hypersensitivity to non-steroidal anti-inflammatory drugs(NSAID) is a distinct phenomenon of severe asthma. Eosinophils play key role in NSAID hypersensitivity as main source prostanoides. The aim the analysis assess effect omalizumab(OMA) on blood eosinophils count(Eo) asthmatic patients with compare those who tolerate NSAID(non-NSAID). Out 38 started OMA therapy positive history was reported by 14 patients, 24 tolerated NSAID. We evaluated Eo level and clinical effectiveness...
No adequate response to OMA in patients with severe allergic asthma is observed up 40% of patients. The aim the current analysis was detect predictor clinical measured by reduction exacerbation rate. <b>Method:</b> 34 treated were prospectively and classified 16th 52th week as responders non-responders. P-value<0.05 considered statistically significant. <b>Results:</b> baseline characteristic study groups respect demographic data, total serum IgE[IU/l], ACQ [points], AQLQ rate exacerb...