A5050091992- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Ferrocene Chemistry and Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Respiratory viral infections research
- Protein Interaction Studies and Fluorescence Analysis
- Graphene and Nanomaterials Applications
- Plant Stress Responses and Tolerance
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- IL-33, ST2, and ILC Pathways
- Multiple Sclerosis Research Studies
- Viral Infections and Immunology Research
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
- biodegradable polymer synthesis and properties
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Bone Tissue Engineering Materials
- Antioxidant Activity and Oxidative Stress
University of Łódź
2016-2025
Edinburgh Royal Infirmary
2023
John Paul II Catholic University of Lublin
2019
Warsaw University of Life Sciences
2019
Centre for Inflammation Research
2007-2008
The Queen's Medical Research Institute
2007-2008
University of Edinburgh
2007-2008
Apoptosis of inflammatory cells and their subsequent clearance (efferocytosis) by macrophages (Mphis) are key mechanisms orchestrating successful resolution inflammation. Although the powerful proinflammatory agents lipopolysaccharide (LPS) tumor necrosis factor alpha (TNF-alpha) influence rates cell apoptosis, little is known about effects on efferocytosis. We have demonstrated that LPS TNF-alpha potently inhibit efferocytosis neutrophils monocyte-derived Mphis. Inhibition was both...
The effects of 50 and 300 mg L(-1) Zn(2+) (50 Zn Zn) were investigated in Triticum aestivum (cv. Żura) grown hydroponically for 7 days. Although wheat treated with took up relatively high amount the metal (8,943 1,503 kg(-1) DW roots shoots, respectively), none morphological cytological parameters changed. After Zn, concentration increased to 32,205 5,553 respectively. It was connected depletion shoot root growth, their fresh dry weight, water content mitotic index meristematic cells....
One of the major limitations for treatment many diseases is an inability drugs to cross cell membrane barrier. Different kinds carriers are being investigated improve drug bioavailability. Among them, lipid or polymer-based systems special interest due their biocompatibility. In our study, we combined dendritic and liposomal analysed biochemical biophysical properties these formulations. Two preparation methods Liposomal Locked-in Dendrimers (LLDs) have been established compared. Carbosilane...
Gene therapy presents an innovative approach to the treatment of previously incurable diseases. The advancement research in field nanotechnology has potential overcome current limitations and challenges conventional methods, therefore unlocking full dendrimers for use gene neurodegenerative disorders. blood-brain barrier (BBB) poses a significant challenge when delivering therapeutic agents central nervous system. In this study, we investigated biophysical properties their complexes with...
Abstract The use of dendrimers as drug and nucleic acid delivery systems requires knowledge their interactions with objects on way to the target. In present work, we investigated interaction a new class carbosilane functionalized polyphenolic caffeic residues human serum albumin, which is most abundant blood protein. addition albumin solution decreased zeta potential albumin/dendrimer complexes compared free increased density fibrillary form shifted fluorescence spectrum towards longer...
ABSTRACT Rhinoviruses are a major cause of respiratory infections, including asthma infectious exacerbations. Human rhinovirus 16 (RV‐16) has been widely shown to infect epithelial cells and the human lung vascular endothelium. RV‐16 was also observed induce an IFN‐β‐dependent mechanism antiviral intracellular mechanisms based on OAS‐1 PKR activity. This study aimed investigate whether microvascular endothelial (HMVEC‐L) infected with display resistance subsequent infections same virus,...
The unique properties of insect silk have attracted attention for years to develop scaffolds tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biomaterials are a promising choice engineering due their versatility, many processing methods. In this study, the physicochemical biological biocomposites formed by combining caddisfly (Hydropsyche angustipennis) polycaprolactone (PCL) were...
Abstract Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating evidence highlights the meaningful impact of estrogen receptors physiology and pathophysiology colon. However, significance G protein-coupled receptor (GPER) on Crohn’s disease (CD), one inflammatory bowel (IBD) types, is still elusive. Our study revealed GPER overexpression at mRNA protein levels patients with CD. To evaluate effects activation/inhibition colitis development, a murine 2, 4,...
Plants have served for centuries as sources of compounds useful human health such antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the diet. Growing demands these make it important to seek new them. Hippophae rhamnoides L. is known a plant with health-promoting properties. In this study we investigated chemical composition biological properties bioactive components ethanol extracts from leaves twigs H. Chemical total content phenolic compounds,...
Tubular polymeric structures have been recognized in the treatment of peripheral nerves as comparable to autologous grafting. The best therapeutic outcomes are obtained with conduits releasing molecules. In this study, a new approach for incorporation biologically active agent-loaded microspheres into structure chitosan/polycaprolactone was developed. support polycaprolactone helix formed by 3D melt extrusion coated dopamine order adsorb nerve growth factor-loaded microspheres. complex...
Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates used as gene drug carriers in anti-cancer therapy, due their properties such size charge. Copper attached the nanoparticles is an important element of many biological processes recently have been widely examined. Zeta potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis haemolytic activity, fluorescence anisotropy techniques were...
Cancer treatment with small interfering RNA (siRNA) is one of the most promising new strategies; however, transfection systems that increase its bioavailability and ensure delivery to target cell are necessary. Transfection may be just vehicular or could contain fragments anticancer activity achieves a synergistic effect siRNA. Cationic carbosilane dendrimers have proved powerful tools as non-viral vectors for siRNA in cancer treatment, their might potentiated by inclusion metallic complexes...
Copper carbosilane metallodendrimers containing chloride ligands and nitrate were mixed with commercially available conventional anticancer drugs, doxorubicin, methotrexate 5-fluorouracil, for a possible therapeutic system. To verify the hypothesis that copper can form conjugates their complexes biophysically characterized using zeta potential size methods. Next, to confirm existence of synergetic effect dendrimers in vitro studies performed. The combination therapy has been applied two...
Abstract Background Neutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation and tissue regeneration. The specific polarisation immune cells is mediated by the modification ‘chromatin landscapes’, which enables differentiated access activity regulatory elements that guarantee their plasticity during inflammation No pattern within histone posttranslational modifications (PTMs) controlling this has been identified. Methods Using in...
Ruthenium atoms located in the surfaces of carbosilane dendrimers markedly increase their anti-tumor properties. Carbosilane have been widely studied as carriers drugs and genes owing to such characteristic features monodispersity, stability, multivalence. The presence ruthenium dendrimer structure enhances successful use anti-cancer therapy. In this paper, activity generation 1 2 against 1301 cells was evaluated using Transmission Electron Microscopy, comet assay Real Time PCR techniques....
The high expression of some ATP-binding cassette (ABC) transporters is linked to multidrug resistance in cancer cells. We aimed determine if I-CBP112, which a CBP/p300 bromodomain inhibitor, altered the vulnerability MDA-MB-231 cell line chemotherapy drugs, are used neoadjuvant therapy patients with triple negative breast (TNBC). cells represent TNBC, for estrogen and progesterone receptors HER2 protein. An I-CBP112-induced decrease all studied ABCs breast, but also lung (A549), hepatic...