A5034160878- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticle-Based Drug Delivery
- Ferrocene Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Alzheimer's disease research and treatments
- Immunotherapy and Immune Responses
- Metal complexes synthesis and properties
- Polymer Surface Interaction Studies
- Cholinesterase and Neurodegenerative Diseases
- Research in Cotton Cultivation
- Natural Language Processing Techniques
- Computational Drug Discovery Methods
- Luminescence and Fluorescent Materials
- Essential Oils and Antimicrobial Activity
- HIV Research and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Antioxidant Activity and Oxidative Stress
- Semantic Web and Ontologies
- Drug Transport and Resistance Mechanisms
- vaccines and immunoinformatics approaches
- Photosynthetic Processes and Mechanisms
University of Łódź
2015-2024
Goethe University Frankfurt
2020
Academy of Sciences Republic of Uzbekistan
2004-2011
Yunusov Institute of the Chemistry of Plant Substances
2011
National University of Uzbekistan
2008
Abstract Maltose‐modified poly(propylene imine) (PPI) dendrimers were synthesized by reductive amination of unmodified second‐ to fifth‐generation PPI in the presence excess maltose. The characterized using 1 H NMR, 13 C and IR spectroscopies; laser‐induced liquid beam ionization/desorption mass spectrometry; dynamic light scattering analyses; polyelectrolyte titration. Their scaffolds have enhanced molecular rigidity their outer spheres, at which two maltose units are bonded former primary...
Alzheimer's disease (AD) is characterized by pathological aggregation of β-amyloid peptides and MAP-Tau protein. β-Amyloid (Aβ) a peptide responsible for extracellular plaque formation. Intracellular aggregates appear as result hyperphosphorylation this cytoskeletal Small, oligomeric forms Aβ are intermediate products that before the amyloid plaques formed. These believed to be most neurotoxic. Dendrimers highly branched polymers, which may find an application in regulation fibril Several...
Summary Beta amyloid (βA) plays a central role in the pathogenesis of most common and devastating neurodegenerative disorder, Alzheimer’s disease (AD). The mechanisms βA neurotoxicity remain controversial, but include dysregulation calcium homeostasis oxidative stress. A large body data suggest that cholesterol significant AD. In mixed cultures containing hippocampal neurons astrocytes, we have shown neurotoxic peptides (1–42 25–35) cause sporadic cytosolic ([Ca 2+ ] c ) signals astrocytes...
One of the major limitations for treatment many diseases is an inability drugs to cross cell membrane barrier. Different kinds carriers are being investigated improve drug bioavailability. Among them, lipid or polymer-based systems special interest due their biocompatibility. In our study, we combined dendritic and liposomal analysed biochemical biophysical properties these formulations. Two preparation methods Liposomal Locked-in Dendrimers (LLDs) have been established compared. Carbosilane...
Gene therapy presents an innovative approach to the treatment of previously incurable diseases. The advancement research in field nanotechnology has potential overcome current limitations and challenges conventional methods, therefore unlocking full dendrimers for use gene neurodegenerative disorders. blood-brain barrier (BBB) poses a significant challenge when delivering therapeutic agents central nervous system. In this study, we investigated biophysical properties their complexes with...
Abstract The use of dendrimers as drug and nucleic acid delivery systems requires knowledge their interactions with objects on way to the target. In present work, we investigated interaction a new class carbosilane functionalized polyphenolic caffeic residues human serum albumin, which is most abundant blood protein. addition albumin solution decreased zeta potential albumin/dendrimer complexes compared free increased density fibrillary form shifted fluorescence spectrum towards longer...
Irresponsiveness of triple negative breast cancer (TNBC) toward conventional therapies has drawn attention siRNA therapeutics. In gene delivery, dendrimers are gaining significant due to their characteristic features and polo-like kinase (PLK1) is reported as a potential target for TNBC. this work, phosphorus polyamidoamine dendrimer (generation 3 4 each type) explored address delivery challenges PLK1 (siPLK1). Dendriplexes were formed complexation was found at 3:1 N/P ratio all by gel...
Abstract The objective of the study was a comparative analysis antihemolytic activity against two Staphylococcus aureus strains (8325-4 and NCTC 5655) as well α-hemolysin membrane modifying action four hydrolysable tannins with different molecular mass flexibility: 3,6-bis- O -di- -galloyl-1,2,4-tri- -galloyl- β - d -glucose (T1), 1,2,3,4,5-penta- (T2), 3- -galloyl-1,2-valoneoyl- (T3) 1,2-di- -galloyl-4,6-valoneoyl- (T4). We showed that all compounds studied manifested effects in range 5–50...
Plants have served for centuries as sources of compounds useful human health such antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the diet. Growing demands these make it important to seek new them. Hippophae rhamnoides L. is known a plant with health-promoting properties. In this study we investigated chemical composition biological properties bioactive components ethanol extracts from leaves twigs H. Chemical total content phenolic compounds,...
Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles could be used to advance modern medicine. One significant pharmacological problem is crossing biological barriers by commonly drugs, e.g., in the treatment of neurodegenerative diseases, which have a blood-brain barrier (BBB) restricting drug delivery. Numerous studies been conducted find appropriate carriers that are safe, biocompatible and efficient. In this work, we evaluate pegylated gold AuNP14a...
Heparin is involved in the pathogenesis of prion diseases, affecting process fibril formation. It has been shown that whether it accelerates or inhibits fibrilogenesis depends on its concentration: peptide PrP 185-208 aggregates presence 0.04 mg ml−1 heparin, but concentrations ten times lower higher cause no aggregation. Polyamidoamine, polypropyleneimine and phosphorus dendrimers previously exhibited anti-prion activity have to interact with heparin. The interactions between cationic...