A5028642771- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Immunotherapy and Immune Responses
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Carbohydrate Chemistry and Synthesis
- Pharmaceutical Practices and Patient Outcomes
- Higher Education Teaching and Evaluation
- Educational Technology in Learning
- Molecular Sensors and Ion Detection
- Graphene and Nanomaterials Applications
- Nanomaterials and Printing Technologies
- Organic Light-Emitting Diodes Research
University of Castilla-La Mancha
2021-2022
Freie Universität Berlin
2012-2021
Universidad de Sevilla
2016-2020
Instituto de Investigaciones Químicas
2020
Universidade de Santiago de Compostela
2008-2017
Center for Research in Molecular Medicine and Chronic Diseases
2017
Centro Singular de Investigación en Química Biológica y Materiales Moleculares
2012
Centro de Investigación Biomédica en Red
2010
Universidad de Zaragoza
2010
Centro de Biología Molecular Severo Ochoa
2010
Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS able cross BBB, bind P/L-selectins accumulate selectively intracranial tumors. We show that has dual targeting properties, as...
Physiological barriers inside of tumor tissue often result in poor interstitial penetration and heterogeneous intratumoral distribution nanoparticle-based drug delivery systems (DDS). Novel, matrix metalloproteinase (MMP)-sensitive peptide-crosslinked nanogels (pNGs) as multistage DDS are reported with a beneficial size reduction property to promote the process deep penetration. Methods: The presented pNGs based on dendritic polyglycerol (dPG) scaffold crosslinked by modified MMP-sensitive...
The incorporation of poly(ethylene glycol) (PEG) chains at the focal point dendrimers results in customizable platforms where careful selection PEG length, nature peripheral groups, and structure generation dendritic block entail materials for specific applications biomedical field. In this focus article, synthesis, properties, PEG-dendritic copolymers are discussed with examples drug gene delivery, tissue repair, diagnosis.
Assembly of the mature human immunodeficiency virus type 1 capsid involves oligomerization protein, CA. The C-terminal domain CA, CTD, participates both in formation CA hexamers and joining through homodimerization. Intact isolated CTD are able to homodimerize solution with similar affinity (dissociation constant order 10 μM); homodimerization mainly an α-helical region. In this work, we show that first-generation gallic acid-triethylene glycol (GATG) dendrimers bind CTD. binding region is...
In this study, dendritic polyglycerol sulfate (dPGS) is evaluated as a delivery platform for the anticancer, tubulin-binding drug paclitaxel (PTX).
Remarkably stable polyion complex micelles with narrow size distribution result from the supramolecular assembly of clicked anionic PEG-dendritic block copolymers oppositely charged polymers.
Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral linkers between charged groups and the globular/rigid dendritic scaffold maximizes this stabilization compared to PIC from linear polymers. As a result, stable at concentrations higher than 3 M NaCl are obtained, which represents highest saline concentration attained with...
Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The synthesized in single step combining free-radical polymerization and mild nanoprecipitation technique. respond to different biological stimuli such low pH reductive environments, resulting more efficient cell proliferation inhibition A549 cells.
The synthesis of a new family amino-functionalized gallic acid-triethylene glycol (GATG) dendrimers and their block copolymers with polyethylene (PEG) has recently being disclosed. In addition, these have shown potential for gene delivery applications, as they efficiently complex nucleic acids form small homogeneous dendriplexes. On this basis, the present study aimed to explore interaction engineered dendriplexes blood components, well stability, cytotoxicity ability enter transfect...
The development of dendriplexes as nanoarchitectures with sterically induced stoichiometry for gene delivery applications is described. ability four generations amino-functionalized gallic acid−triethylene glycol (GATG) dendrons and PEG−dendritic block copolymers to efficiently condense pDNA was evaluated. A characteristic nitrogen phosphate ratio (N/P) complete condensation revealed each dendrimer. Larger N/P ratios had little effect on the size ξ potential dendriplexes. Dendriplexes are...
Abstract A general synthetic strategy to polyethylene glycol (PEG)‐dendritic block copolymers of the GATG (gallic acid–triethylene glycol) family is described from commercially available PEG different molecular weights and architectures. Glycosylation resulting azide‐terminated with fucose by copper‐catalyzed azide–alkyne cycloaddition (CuAAC) afforded a toolbox study effect on multivalent binding lectin UEA‐I surface plasmon resonance (SPR, surface) isothermal titration calorimetry (ITC, in...
An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers the GATG family is described as a function dendritic generation, metal (Au, CdSe) and molar ratio. The biocompatibility generated analysed terms their aggregation physiological media, cytotoxicity uptake by macrophages relates to PEG density surface hybrids.
A facile synthesis of thermoresponsive nanogels (NGs) with potential applications as drug delivery systems is reported.
The anomeric configuration of the reducing end Man<sub>9</sub> does not influence binding to DC-SIGN.