A5022565141- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pituitary Gland Disorders and Treatments
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Traumatic Brain Injury and Neurovascular Disturbances
- Management of metastatic bone disease
- Ultrasound and Hyperthermia Applications
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Cerebrospinal fluid and hydrocephalus
- CNS Lymphoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
Tel Aviv University
2014-2025
Tel Aviv Sourasky Medical Center
2014-2025
Rambam Health Care Campus
2024-2025
Technion – Israel Institute of Technology
2024-2025
Digital China Health (China)
2019
Digital Health Cooperative Research Centre
2019
Radiation Oncology Associates
2019
Johns Hopkins University
2010-2014
Sheba Medical Center
2001-2012
Johns Hopkins Medicine
2010-2012
A perfusable vascularized 3D-bioprinted cancer model with stromal cells can be used for personalized therapy and target discovery.
Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS able cross BBB, bind P/L-selectins accumulate selectively intracranial tumors. We show that has dual targeting properties, as...
Abstract Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays crucial role in progression. Among the stromal cells, microglia were shown to facilitate GB invasion and immunosuppression. However, reciprocal mechanisms by which cells alter microglia/macrophages behavior are not fully understood. We propose that these involve adhesion molecules such as Selectins family. These proteins involved immune modulation immunity. show...
OBJECTIVE The aim of this study was to assess in-hospital (immediate) postoperative pain scores and analgesic consumption (primary goals) preoperative anxiety sleep quality (secondary in patients who underwent craniotomy were treated with pregabalin (PGL). Whenever possible, out-of-hospital analgesics usage data obtained as well. METHODS This prospective, randomized, double-blind controlled conducted consenting elective for brain tumor resection at Tel Aviv Medical Center between 2012 2014....
Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis great clinical importance. We used a mouse model spontaneous study interactions melanomas with microenvironment. find that CXCL10 upregulated in metastasis-associated astrocytes mice and humans functionally important for chemoattraction cells. Moreover, CXCR3, receptor CXCL10, brain-tropic Targeting expression CXCR3 by...
Complete tumor removal during surgery has a great impact on patient survival.To that end, the surgeon should detect tumor, remove it and validate there are no residual cancer cells left behind.Residual at incision margin of tissue removed associated with recurrence poor prognosis for patient.In order to completely minimal collateral damage healthy tissue, is need diagnostic tools will differentiate between its normal surroundings.Methods: We designed, synthesized characterized three novel...
Glioblastoma (GBM) is the most aggressive form of glioma, with poor prognosis exhibited by patients, and a median survival time less than 2 years. We assemble cohort 87 GBM patients whose ranges from 3 months up to 10 years perform both high-resolution mass spectrometry proteomics RNA sequencing (RNA-seq). Integrative analysis protein expression, patient clinical information enables us identify specific immune, metabolic, developmental processes associated as well determine whether they are...
Abstract Creative thinking represents a major evolutionary mechanism that greatly contributed to the rapid advancement of human species. The ability produce novel and useful ideas, or original thinking, is thought correlate well with unexpected, synchronous activation several large-scale, dispersed cortical networks, such as default network (DN). Despite vast amount correlative evidence, causal link between creativity has yet be demonstrated. Surgeries for resection brain tumors lie in...
Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) primary tissues requires use viably dissociated single cells. Inadequate methods for tissue dissociation generate considerable loss in quantity cells produced cells' viability. Improper may also demote quality data attained functional assays due to presence large quantities cellular debris containing immune-activatory danger associated patterns, increased degraded proteins RNA. Over 40 resected BTs...
The establishment of theranostic devices by combining multimodal real-time intraoperative imaging for brain tumor surgery with targeted drug delivery may provide therapeutic advantages patients malignant gliomas. Our group has recently developed a new generation novel microbubbles (MBs), an air core and crosslinked poly(vinyl alcohol) shell, called PVA MBs. MB surface was engineered to support near-infrared (NIR) fluorescence probe (C790) the surgical microscope. attachment cyclic...
Colorectal cancer (CRC) ranks as the fourth most common cause of brain metastasis (BM), with its incidence on rise. However, molecular mechanisms driving formation these lesions from CRC remain unclear. We analyzed FoundationOne genomic database, which includes over 35,000 samples both local and metastatic sites. The role insulin receptor substrate 2 (IRS2) in tropism was investigated using various vitro (co-culture systems 3D sphere assays), vivo (intracranial subcutaneous mouse models), ex...
Glioblastoma multiforme (GBM) is the most common and aggressive primary neoplasm of brain. Poor prognosis mainly attributed to tumor heterogeneity, invasiveness, drug resistance. microRNA-based therapeutics represent a promising approach due their ability inhibit multiple targets. In this work, we aim restore oncosuppressor activity microRNA-34a (miR-34a) in GBM. We developed cationic carrier system, dendritic polyglycerolamine (dPG-NH2), which remarkably improves miRNA stability,...
Abstract Brain metastases are common in patients with advanced melanoma and constitute a major cause of morbidity mortality. Between 40% 60% melanomas harbor BRAF mutations. Selective inhibitor therapy has yielded improvement clinical outcome; however, genetic discordance between the primary lesion metastatic tumor been shown to occur. Currently, only way characterize landscape brain metastasis is by tissue sampling, which carries risks potential complications. The aim this study was...
OBJECTIVE Primary central nervous system lymphoma (PCNSL) is a rare CNS tumor with poor prognosis. It usually diagnosed by needle biopsy and treated mainly high-dose chemotherapy. Resection currently not considered standard treatment option. A possible prolonged survival after resection of PCNSL lesions in selected patients has been suggested, but selection criteria for surgery, especially solitary lesions, have never established. METHODS The authors retrospectively searched their patient...
Summary Background Preoperative determinants of surgical risk in elderly patients with pituitary tumour are not fully defined. The aim this study was to quantify operative for these patients. Design and methods We performed a retrospective analysis the Nationwide Inpatient Sample (1998–2005), database containing discharge information from stratified, random sample 20% all non‐federal hospitals 37 states. Patients >65 years old who underwent resection were identified by ICD‐9 coding....
Differentiation between small-cell lung cancer (SCLC) from non-small-cell (NSCLC) brain metastases is crucial due to the different clinical behaviors of two tumor types. We propose use a deep learning and transfer approach based on conventional magnetic resonance imaging (MRI) for non-invasive classification SCLC vs. NSCLC metastases. Sixty-nine patients with metastasis origin were included. Of them, 44 had 25 SCLC. Classification was performed EfficientNet architecture crop images lesion...
Technical advances and the increasing role of interdisciplinary decision-making may warrant formal definitions expertise in surgical neuro-oncology.
OBJECTIVE: Gliomas account for most primary brain tumors in adults, and survival correlates with the grade vascularity of tumor. The degree tumor-related angiogenesis seems to be a significant predictor tumor progression, recurrence, metastatic spread variety malignant diseases, including tumors. Our study's objective was quantify levels two angiogenic factors, basic fibroblast growth factor (bFGF) vascular endothelial (VEGF), cerebrospinal fluid (CSF) serum patients gliomas correlate these...
Dynamic changes in neuroinflammation and glutamate NMDA receptors (NMDAR) have been noted traumatic ischemic brain injury.Here we investigate the time course regional distribution of these their relationship with atrophy a rat model penetrating injury.Quantitative autoradiography, marker [3H]PK11195 NMDAR antagonist [125I]iodoMK801, was performed on brains animals subjected to unilateral wireknife injury at level striatum killed 3 - 60 days later. Regional measured by morphometry.The...
Abstract Tumor-treating fields (TTFields) are a localized, antitumoral therapy using alternating electric fields, which impair cell proliferation. Combining TTFields with tumor immunotherapy constitutes rational approach; however, it is currently unknown whether TTFields’ locoregional effects compatible T functionality. Healthy donor PBMCs and viably dissociated human glioblastoma samples were cultured under either standard or conditions. Select pivotal functions measured by multiparametric...