A5040917414- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cerebral Venous Sinus Thrombosis
- Cutaneous Melanoma Detection and Management
- Single-cell and spatial transcriptomics
- 3D Printing in Biomedical Research
- Medical Imaging and Analysis
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Research Studies
- Neurosurgical Procedures and Complications
- MRI in cancer diagnosis
- Vascular Anomalies and Treatments
- Acute Ischemic Stroke Management
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
St. Luke's Hospital
2024-2025
Tel Aviv Sourasky Medical Center
2017-2025
Baylor College of Medicine
2023
Tel Aviv University
2019-2023
Abstract Brain metastases are common in patients with advanced melanoma and constitute a major cause of morbidity mortality. Between 40% 60% melanomas harbor BRAF mutations. Selective inhibitor therapy has yielded improvement clinical outcome; however, genetic discordance between the primary lesion metastatic tumor been shown to occur. Currently, only way characterize landscape brain metastasis is by tissue sampling, which carries risks potential complications. The aim this study was...
Background and purpose The transradial (TR) approach is an alternative to the traditional transfemoral (TF) for extracranial carotid artery stenting (eCAS). A successful eCAS may be contingent on geometry of great vessels. We aimed analyze vessel identify predictors stent placement, enabling tailored approaches. Materials methods Multicenter retrospective data was collected from electronic health record patients who underwent January 2018 December 2022. Geometric parameters vessels were...
Differentiation between small-cell lung cancer (SCLC) from non-small-cell (NSCLC) brain metastases is crucial due to the different clinical behaviors of two tumor types. We propose use a deep learning and transfer approach based on conventional magnetic resonance imaging (MRI) for non-invasive classification SCLC vs. NSCLC metastases. Sixty-nine patients with metastasis origin were included. Of them, 44 had 25 SCLC. Classification was performed EfficientNet architecture crop images lesion...
Abstract Tumor-treating fields (TTFields) are a localized, antitumoral therapy using alternating electric fields, which impair cell proliferation. Combining TTFields with tumor immunotherapy constitutes rational approach; however, it is currently unknown whether TTFields’ locoregional effects compatible T functionality. Healthy donor PBMCs and viably dissociated human glioblastoma samples were cultured under either standard or conditions. Select pivotal functions measured by multiparametric...
Gliadel occasionally induces edema following its implantation. We aimed to correlate such post-surgical radiological changes efficacy and subsequent survival. Fifty-six patients with recurrent high grade glioma were treated between 2005 2016 Volumetric measurements of MRI features, including FLAIR abnormalities, tumor bulk (volume gadolinium enhancement on T1) resection cavity volumes over time conducted. To assess dynamics time, linear regression trendlines for each these calculated...
Background Multiple studies have highlighted the importance of carotid artery stenting (CAS) operator's experiences. However, fellowship‐trained neurointerventionalists remain an under‐represented specialty in literature. We aim to report complication rate CAS performed exclusively by neurointerventionalists. Methods Retrospective cohort study regarding symptomatic and asymptomatic stenosis was collected at multiple comprehensive stroke centers. The primary outcome included a composite...
Tumor Treating Fields (TTFields) is a novel therapeutic modality approved for the treatment of recurrent glioblastoma (GBM) and has recently been shown in large pivotal study to be very effective newly-diagnosed GBM. The alternating electric fields interfere with microtubule assembly mitotic spindle, causes dielectrophoretic movement intracellular organelles during phases cell division, lead disruption chromosome segregation subsequent death. Nevertheless, TTFields-mediated gene expression...
Abstract Objective: Gliadel® occasionally induces edema following its implantation. We aimed to correlate such post-surgical radiological changes efficacy and subsequent survival. Methods : Fifty-six patients with recurrent glioblastoma were treated between 2005-2016 Volumetric measurements of MRI features, including FLAIR abnormalities, tumor bulk (volume gadolinium enhancement on T1) resection cavity volumes over time conducted. To assess dynamics time, linear regression trendlines for...
Abstract PURPOSE : Non-small cell lung cancer (NSCLC), the most prevalent subtype of cancer, tends to metastasize brain. Between 10-60% NSCLCs harbor an activating mutation in epidermal growth factor receptor (EGFR), which may be targeted with selective EGFR inhibitors. However, due a high discordance rate between molecular profile primary tumor and brain metastases (BMs), identifying individual patient’s status BMs necessitates tissue diagnosis via invasive surgical procedure. We employed...