A5000263041- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Eating Disorders and Behaviors
- Complement system in diseases
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Evolutionary Psychology and Human Behavior
- Neonatal Respiratory Health Research
- Mass Spectrometry Techniques and Applications
- Lung Cancer Treatments and Mutations
- Biochemical Analysis and Sensing Techniques
- Advanced Biosensing Techniques and Applications
- Lipid metabolism and biosynthesis
- Regulation of Appetite and Obesity
- Gene expression and cancer classification
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Immune cells in cancer
- Cell Image Analysis Techniques
- Molecular Biology Techniques and Applications
- vaccines and immunoinformatics approaches
- Single-cell and spatial transcriptomics
Stanford University
2025
Tel Aviv University
2017-2024
Science for Life Laboratory
2024
KTH Royal Institute of Technology
2024
Weizmann Institute of Science
2021
Glioblastoma (GBM) is the most aggressive form of glioma, with poor prognosis exhibited by patients, and a median survival time less than 2 years. We assemble cohort 87 GBM patients whose ranges from 3 months up to 10 years perform both high-resolution mass spectrometry proteomics RNA sequencing (RNA-seq). Integrative analysis protein expression, patient clinical information enables us identify specific immune, metabolic, developmental processes associated as well determine whether they are...
Abstract Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that exposure induces food-seeking behavior, food intake, behavior intake men, but not women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB leads increased weight gain, with a sexual dimorphism towards males....
Obesity has become one of the leading pathophysiologic disorders in recent years. Adipose tissue is main related to obesity and known play a role various physiological complications, including type 2 diabetes. To better understand how fat develops, we used an vitro live cell imaging system quantify adipogenesis by means nondestructive digital monitor accumulation intracellular lipid droplets (LDs), hallmark adipogenesis, from macro- micro-scale. Analyzing cells' shape at single-cell level...
Ultraviolet (UV) light affects endocrinological and behavioral aspects of sexuality via an unknown mechanism. Here we discover that ultraviolet B (UVB) exposure enhances the levels sex-steroid hormones sexual behavior, which are mediated by skin. In female mice, UVB increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in larger ovaries; extends estrus days; anti-Mullerian (AMH) expression. also responsiveness attractiveness females male-female interactions. Conditional...
Pancreatic islets are highly specialized tissue compartments that regulate metabolism, and their dysfunction contributes to diseases such as prediabetes diabetes. Characterizing islet morphology cell plasticity is essential for understanding these pathophysiological states, yet high-resolution spatial proteomics remains challenging due the islets' small size cellular complexity. Here, we present multiplexed deep visual (mxDVP), an approach integrates high-plex imaging with ultra-sensitive...
MicroRNAs (miR) are small RNA molecules that shape the cell transcriptome and proteome through regulation of mRNA stability translation. Here, we examined their function as determinants resistance to complement-dependent cytotoxicity (CDC). To achieve this goal, compared expression microRNAs between complement-resistant -sensitive K562 leukemia, Raji lymphoma, HCT-116 colorectal carcinoma cells. Global microRNA array analysis identified miR-150, miR-328, miR-616 regulators CDC resistance....
The respiratory system, including the lungs, is essential for terrestrial life. While recent research has advanced our understanding of lung development, much still relies on animal models and transcriptome analyses. In this study conducted within Human Developmental Cell Atlas (HDCA) initiative, we describe protein-level spatiotemporal organization during first trimester human gestation. Using high-parametric tissue imaging with a 30-plex antibody panel, analyzed samples from 6 to 13...
The respiratory system, including the lungs, is essential for terrestrial life. While recent research has advanced our understanding of lung development, much still relies on animal models and transcriptome analyses. In this study conducted within Human Developmental Cell Atlas (HDCA) initiative, we describe protein-level spatiotemporal organization during first trimester human gestation. Using high-parametric tissue imaging with a 30-plex antibody panel, analyzed samples from 6 to 13...
Summary Despite extensive research, internal tumor heterogeneity presents enormous challenges to achieve complete therapeutic responses. Changes in protein expression are central determinants of cancer phenotypes that reflect potential targets. However, previous proteomic studies did not address heterogeneity, therefore, masked the necessary spatial resolution a comprehensive understanding complexity. Here we present first large-scale multi-focal breast study 330 regions which associated...
<div>Abstract<p>MicroRNAs (miR) are small RNA molecules that shape the cell transcriptome and proteome through regulation of mRNA stability translation. Here, we examined their function as determinants resistance to complement-dependent cytotoxicity (CDC). To achieve this goal, compared expression microRNAs between complement-resistant -sensitive K562 leukemia, Raji lymphoma, HCT-116 colorectal carcinoma cells. Global microRNA array analysis identified miR-150, miR-328, miR-616...
<div>Abstract<p>MicroRNAs (miR) are small RNA molecules that shape the cell transcriptome and proteome through regulation of mRNA stability translation. Here, we examined their function as determinants resistance to complement-dependent cytotoxicity (CDC). To achieve this goal, compared expression microRNAs between complement-resistant -sensitive K562 leukemia, Raji lymphoma, HCT-116 colorectal carcinoma cells. Global microRNA array analysis identified miR-150, miR-328, miR-616...
<p>Supplementary Array S1</p>
<p>Supplementary Array S1</p>
Introduction One of the major obstacles in breast cancer treatment is its high degree heterogeneity and ambiguous classification. The molecular subtypes histological are routinely defined clinic to determine modalities; however often these distinct co-exist single tumours therefore lead resistance. Here, we aim delineate proteomic landscapes intratumoral diversity based on clinical-pathological parameters using mass spectrometry-based microproteomics. Material methods Using histopathological...
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual hormonal features enhanced by UVB are mediated skin. In mice, UV exposure increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in ovary size, extended estrus days, anti-Mullerian (AMH) expression. It likewise enhances responsiveness attractiveness females heterosexual interactions...