A5010597332- Mast cells and histamine
- Amyloidosis: Diagnosis, Treatment, Outcomes
- melanin and skin pigmentation
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Polyamine Metabolism and Applications
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- RNA and protein synthesis mechanisms
- Cardiac Valve Diseases and Treatments
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA regulation and disease
- Aortic Thrombus and Embolism
- Hormonal and reproductive studies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Amino Acid Enzymes and Metabolism
- Cardiomyopathy and Myosin Studies
- Parathyroid Disorders and Treatments
- Vaccine Coverage and Hesitancy
Hebrew University of Jerusalem
1996-2023
Kaplan Medical Center
2017-2023
Hadassah Medical Center
2004-2017
Soroka Medical Center
2016
Myocarditis and pericarditis are potential post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. We aimed to study the incidence myocarditis pericarditis. Retrospective cohort 196,992 adults after infection in Clalit Health Services members Israel between March 2020 January 2021. Inpatient diagnoses were retrieved day 10 positive PCR. Follow-up was censored on 28 February 2021, with minimum observation 18 days. The control 590,976 at least one negative...
High levels of microphthalmia transcription factor (MITF) expression have been described in several cell types, including melanocytes, mast cells, and osteoclasts. MITF plays a pivotal role the regulation specific genes these cells. Although its mRNA has found to be present relatively high heart, cardiac never explored. Here we show that heart isoform is expressed cardiomyocytes can induced by β-adrenergic stimulation but not paired box gene 3 (PAX3), regulator melanocyte isoform. In 2 mouse...
Ultraviolet (UV) light affects endocrinological and behavioral aspects of sexuality via an unknown mechanism. Here we discover that ultraviolet B (UVB) exposure enhances the levels sex-steroid hormones sexual behavior, which are mediated by skin. In female mice, UVB increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in larger ovaries; extends estrus days; anti-Mullerian (AMH) expression. also responsiveness attractiveness females male-female interactions. Conditional...
Objective: Gallium-68 (Ga-68) DOTA-1-NaI3-octreotide (DOTA-NOC) positron emission tomography (PET)/computed (CT) is increasingly used for neuroendocrine tumors (NETs), often found primarily in the pancreas. However, physiologic uptake of DOTA-NOC has been described uncinate process We studied this organ. Materials and Methods: Ninety-six patients underwent 103 scans, with pathology-proven pancreatic NET (n = 40) nonpancreatic or biochemical suspicion 63). Results: was detected 35 documented...
Significance The cellular mechanisms underlying the transition from compensatory to deleterious cardiac hypertrophy remain be elucidated. In current work, we demonstrate decreased ErbB2 interacting protein (Erbin) expression in human failing hearts and, using mice models, show that Erbin is important for compensated hypertrophy. Our findings reveal a previously unidentified link between and ERK signaling heart implicate development of failure. particularly interesting due its...
Abstract Aims Cardiac amyloidosis typically manifests as heart failure with preserved left ventricular function due to extracellular plaques comprising aggregated TTR. Despite recent success in halting disease progression a TTR stabilizer and encouraging preliminary findings silencers, these agents are not targeting preexisting plaques. Herein, we report the development of novel monoclonal antibody capable attenuating experimental cardiac amyloidosis. Methods results We generated an IgG1...
Imaging with (68)Ga-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-octreotide analogs has become an important modality in patients neuroendocrine tumors (NETs). In addition to high uptake NET lesions, prominent physiologic radiotracer activity been reported the pituitary gland, pancreas, adrenal glands, liver, and spleen, faint thyroid gastrointestinal tract. This article describes previously unknown sites of 68Ga-DOTA-1-NaI3-octreotide (NOC) unrelated NETs.One...
Respiratory gating and gate optimization strategies present solutions for overcoming image degradation caused by respiratory motion in PET traditionally utilize hardware systems and/or employ complex processing algorithms. In this work, we aimed to advance recently emerging data-driven methods introduce a new strategy optimizing the four-dimensional data based on information contained that data. These algorithms are combined form an automated correction workflow.Software-based were applied...
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) with preserved left ventricular ejection fraction (LVEF), typically presenting as restrictive cardiomyopathy. The potential co-existence ATTR-CA systolic has not been studied. aim this study to describe the prevalence and its clinical characteristics in HF patients reduced LVEF.
The microphthalmia transcription factor (Mitf) is critical for the survival and differentiation of a variety cell types. While on transcript level it has been noted that melanocytes cardiomyocytes express specific Mitf isoforms, mast cells several mainly Mitf-H Mitf-MC, whose function not thoroughly investigated. We found in expression isoforms dependent physiological stimuli cause major shifting promoter usage internal splicing. For example, activation c-kit signaling pathway almost totally...
Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a membrane receptor myeloid cells that mediates cellular phagocytosis and inflammation. TREM2 its soluble extracellular domain are clearly implicated neuroinflammation neurodegeneration. sTREM2 also expressed atherosclerotic macrophages. We hypothesized would predict cardiovascular mortality patients with established coronary atherosclerosis (CAD). Consecutive undergoing angiography the establishment of diagnosis CAD (n = 230)...
The aim of this study was to examine the prevalence amyloid transthyretin (ATTR) cardiac amyloidosis in patients 1-2 years after trans-catheter aortic valve replacement (TAVR) and assess their clinical echocardiographic outcome long-term survival.We enrolled 88 patients, mean age 81 years, 534 (390-711) days TAVR. Patients underwent a Tc99m-PYP scintigraphy for diagnosis ATTR amyloidosis. Eleven (12.5%) participants were diagnosed with Eighty eight per cent without New York Heart Association...
Context. Various data suggest seasonal variation in testosterone levels. However, previous studies are limited by their size or variability baseline characteristics. Objectives. The aim of the study was to evaluate a large cohort males with wide range age, metabolic status, and coexistent morbidities whether month blood test performance associated total bioavailable levels independent body mass index (BMI), existing cardiovascular disease (CVD), CVD risk factors. Methods. Cross-sectional...