A5042565231- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Issues in Pregnancy
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiovascular Effects of Exercise
- Aortic Thrombus and Embolism
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Pericarditis and Cardiac Tamponade
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
- Trace Elements in Health
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Streptococcal Infections and Treatments
Kaplan Medical Center
2016-2025
Hebrew University of Jerusalem
2008-2024
Tel Aviv University
2014-2024
Assaf Harofeh Medical Center
2024
Assuta Medical Center
2021
Sheba Medical Center
2016
Soroka Medical Center
2016
Rabin Medical Center
2016
Soonchunhyang University
2016
Hadassah
2012
Nonalcoholic fatty liver disease (NAFLD) is linked to the metabolic syndrome. The aim of present study determine effect syndrome on left ventricular (LV) geometry and function using as a model patients with NAFLD. Thirty-eight NAFLD, less than 55 years age normal exercise test, were compared an sex-matched control group. Patients diabetes mellitus, hypertension, body mass index>40 excluded. A complete echocardiographic including tissue Doppler imaging (TDI) was performed. following...
Ischemic cardiac damage is associated with upregulation of pro-inflammatory cytokines, as well invasion lymphocytes into the heart. Regulatory T cells (Tregs) are known to exert a suppressive effect on several immune cell types. We sought determine whether Treg pool influenced by myocardial and Tregs transfer deletion affect remodeling.The number functional activity were assayed in mice subjected experimental infarction. The numbers splenocyte-derived ischemic significantly higher after...
Recent studies suggest that angiogenic imbalance during pregnancy may lead to acute peripartum cardiomyopathy (PPCM). We propose and residual cardiac dysfunction exist even after recovery from PPCM.Twenty-nine women at least 12 months presentation with PPCM, who exhibited of left ventricular (LV) ejection fraction (≥50%), were included in the study (mean age 35±6 years, LV 61.0±3.9%). The number circulating endothelial progenitor cells (EPCs) plasma levels proangiogenic vascular growth...
The influence of hemodynamic changes at presentation on the recovery left ventricular (LV) function in peripartum cardiomyopathy (PPCM) patients remains uncertain. This study aims to identify patterns individuals with PPCM. included women PPCM from 2 databases Israel and Indonesia. Conventional echocardiography, 2-dimensional strain, myocardial work, noninvasive pressure-volume loop analysis were performed subsequent data clustering. Among 89 (median age 32 years, IQR: 8.7 years; LV ejection...
Aortic valve stenosis of any degree is associated with poor outcomes.
The rat heart is commonly used as an experimental model of the human in both health and disease states, assuming that function rats humans alike. When studying a model, echocardiography usually performed on sedated rats, whereas standard adult does not require any sedation. Since results are inferred to alert humans, present study, we tested hypothesis differences left ventricular (LV) may be between by low dose ketamine-xylazine humans. Echocardiography was applied 110 healthy 120 Strain...
Abstract Aims Cardiac amyloidosis typically manifests as heart failure with preserved left ventricular function due to extracellular plaques comprising aggregated TTR. Despite recent success in halting disease progression a TTR stabilizer and encouraging preliminary findings silencers, these agents are not targeting preexisting plaques. Herein, we report the development of novel monoclonal antibody capable attenuating experimental cardiac amyloidosis. Methods results We generated an IgG1...
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) with preserved left ventricular ejection fraction (LVEF), typically presenting as restrictive cardiomyopathy. The potential co-existence ATTR-CA systolic has not been studied. aim this study to describe the prevalence and its clinical characteristics in HF patients reduced LVEF.
Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter valve repair may therefore be a suitable therapy. However, data on clinical outcomes patients in acute setting are scarce, especially those reduced left ventricle (LV) dysfunction. We conducted multinational, collaborative analysis from 21 centers for who were, within 90 days MI, treated MitraClip due to MR. The cohort was divided according median ejection...
Abstract Aims To describe the effect of subsequent pregnancies (SSP) on left ventricular (LV) function and outcomes in patients with peripartum cardiomyopathy (PPCM). Methods Among146 women PPCM who were prospectively followed at two medical centres Israel (2007–2019), 75 SSPs (in 50 women) identified: 8 miscarriages, terminations, 59 life birth. Results Forty‐five full‐term [mean age was 32.9 ± 4.1 years, LV ejection fraction (LVEF) 57.7 5.1%] analysed. Data LVEF 1‐month post‐delivery...
Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a membrane receptor myeloid cells that mediates cellular phagocytosis and inflammation. TREM2 its soluble extracellular domain are clearly implicated neuroinflammation neurodegeneration. sTREM2 also expressed atherosclerotic macrophages. We hypothesized would predict cardiovascular mortality patients with established coronary atherosclerosis (CAD). Consecutive undergoing angiography the establishment of diagnosis CAD (n = 230)...
Left ventricular (LV) two-dimensional longitudinal strain (2DLS) analysis by echocardiography has been suggested as a useful tool for the detection of acute coronary syndromes (ACS). Our aim was to determine whether 2DLS could assist in triage patients with chest pain (CP) emergency department (ED). We prospectively enrolled presenting ED CP and suspected ACS but without diagnostic ECG or elevated troponin. An echocardiogram performed within 24 h CP. For each patient, histogram LV myocardial...
Calcific aortic stenosis (AS) is an active process sharing similarities with atherosclerosis and chronic inflammation. The pathophysiology of AS notable for three cardinal components: inflammation, fibrosis calcification. Monocytes play a role in each these processes. circulating monocytes not clear. aim the present study was to association between apoptotic non CD14(+) features.We assessed number 54 patients significant (aortic valve area 0.74 ± 0.27 cm(2)) compared them 33 similar risk...
Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable (BEVs) with consequent response remains uncertain.Patients severe symptomatic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) subpopulation dynamics as well neutrophil lymphocyte ratio (NLR)...
The aim of this study was to examine the prevalence amyloid transthyretin (ATTR) cardiac amyloidosis in patients 1-2 years after trans-catheter aortic valve replacement (TAVR) and assess their clinical echocardiographic outcome long-term survival.We enrolled 88 patients, mean age 81 years, 534 (390-711) days TAVR. Patients underwent a Tc99m-PYP scintigraphy for diagnosis ATTR amyloidosis. Eleven (12.5%) participants were diagnosed with Eighty eight per cent without New York Heart Association...
Aims: Myocardial abnormalities are common during COVID-19 infection and recovery. We examined left (LV) right (RV) ventricular longitudinal strain in patients who had recovered from assessed the correlation with exercise capacity. Methods results: One hundred eighty-four consecutive history of disease been referred to rest or stress echocardiography because symptoms, mainly dyspnea chest pain, were included study. These compared 106 similar age, risk factor profile no disease. Clinical...
MicroRNAs are short non-coding RNAs that regulate gene expression. The aim of this study was to gain an understanding the possible role miR-106b~ 25 microRNA cluster in regulating atherosclerosis mice.MiR-106b~ knockout mice were outcrossed into Apolipoprotein E (ApoE) background generate double mice. At 36 weeks age, lesion size evaluated aortic sinus by oil-red-O staining.Lesion 2-fold smaller KO comparison ApoE In addition, collagen staining showed a trend towards stable plaque phenotype...
Aortic stenosis (AS) is the most common valvular disease. Endothelial progenitor cells (EPCs) have a role in repair of endothelial surfaces after injury. Reduced numbers EPCs are associated with dysfunction and adverse clinical events, suggesting that injury absence sufficient by circulating promotes progression vascular possibly disorders. The aim this study was to assess EPC number patients AS predictive value their levels on prognosis.The determined flow cytometry 241 control group 73...