A5103098651- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Cancer Risks and Factors
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Testicular diseases and treatments
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- Childhood Cancer Survivors' Quality of Life
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Noise Effects and Management
- Sperm and Testicular Function
- Diet and metabolism studies
Tel Aviv University
2016-2025
Israel Defense Forces Medical Corps
2014-2023
Sheba Medical Center
1986-2022
Rabin Medical Center
1987-2021
Emory University
2013
Ben-Gurion University of the Negev
1986-2011
Brigham and Women's Hospital
2010
Tel Aviv Sourasky Medical Center
2010
Soroka Medical Center
1986
Hadassah Medical Center
1986
The association of body-mass index (BMI) from adolescence to adulthood with obesity-related diseases in young adults has not been completely delineated.
Although prehypertension at adolescence is accepted to indicate increased future risk of hypertension, large-scale/long follow-up studies are required better understand how adolescent blood pressure (BP) tracks into young adulthood. We studied 23 191 male and 3789 female adolescents from the Metabolic Lifestyle Nutrition Assessment in Young Adults cohort (mean age: 17.4 years) with BP <140/90 mm Hg enrollment or categorized by current criteria for pediatric body mass index (BMI) values....
OBJECTIVE Association between white blood cell (WBC) count and diabetes risk has been recently suggested. We assessed whether WBC is an independent factor for incidence among young healthy adults. RESEARCH DESIGN AND METHODS was measured in 24,897 (mean age 30.8 ± 5.36 years), normoglycemic men with range of 3,000 to 12,000 cells/mm3. Participants were periodically screened during a mean follow-up 7.5 years. RESULTS During 185,354 person-years follow-up, diagnosed 447 subjects. A...
OBJECTIVE Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D early adulthood. RESEARCH DESIGN AND METHODS A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.4 years) during 1996–2016. Data were linked to Israeli National Diabetes Registry. Weight and height measured entry. Cox proportional models applied. RESULTS During 15,810,751 person-years, 2,177 people (69% men)...
OBJECTIVE To determine diabetes incidence over time among obese young adults without metabolic risk factors. RESEARCH DESIGN AND METHODS Incident during a median follow-up of 6.1 years was assessed 33,939 men (mean age 30.9 ± 5.2 years) the Metabolic, Lifestyle and Nutrition Assessment in Young Adults cohort who were stratified for BMI number abnormalities (based on Adult Treatment Panel-III). Metabolically healthy (MH) obesity defined as ≥30 kg/m2 presence normoglycemia, normal blood...
Body mass index (BMI) (calculated as weight (kg)/height (m)2) and height are linked to the pathogenesis of low back pain, but evidence-based confirmation is lacking. We examined prevalence pain in adolescents its association with BMI height. Disability clauses (official military limitations related a person's health status) indicating severity were divided according symptoms alone objective corroborating findings. All 829,791 males females undergoing mandatory premilitary recruitment...
There are limited data on long-term comorbidities and mortality among patients with familial Mediterranean fever (FMF). Our objective was to evaluate death rates individuals FMF.
The sequelae of increasing childhood obesity are major concern. We assessed the association BMI in late adolescence with diabetes mortality midlife.The values 2,294,139 Israeli adolescents (age 17.4 ± 0.3 years), measured between 1967 and 2010, were grouped by U.S. Centers for Disease Control Prevention age/sex percentiles ordinary values. outcome, obtained linkage official national records, was death attributed to mellitus (DM) as underlying cause. Cox proportional hazards models...
Hypertension is a leading risk factor of cardiovascular morbidity and mortality. The role nonmalignant hypertension as the sole initiating end-stage renal disease (ESRD) in non-African American populations has recently been questioned.To investigate association between future ESRD otherwise healthy adolescents.This retrospective cohort study examined data 16- to 19-year-old candidates for military service Israel Defense Forces January 1, 1967, December 31, 2013. Data were obtained from...
There is a continuous rise in the prevalence of adolescent obesity and incidence stroke among young adults many Western countries, but association between them unclear.A nationwide population-based study 1 900 384 Israeli adolescents (58% men; mean age, 17.3 years) who were evaluated before mandatory military service during 1985 2013. Body mass index was classified according to US Center for Disease Control Prevention percentiles. Primary outcome first event as recorded by National Stroke...
Myocarditis and pericarditis are potential post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. We aimed to study the incidence myocarditis pericarditis. Retrospective cohort 196,992 adults after infection in Clalit Health Services members Israel between March 2020 January 2021. Inpatient diagnoses were retrieved day 10 positive PCR. Follow-up was censored on 28 February 2021, with minimum observation 18 days. The control 590,976 at least one negative...
Background The association between white blood cell (WBC) count and coronary artery disease (CAD) is unknown in young adults. Our objective was to assess the WBC its changes over time with CAD incidence Metabolic, Life-style Nutrition Assessment Young adults (MELANY) study, a cohort of Israeli army personnel. Methods Findings 29,120 apparently healthy men (mean age; 31.2±5.5 years) normal baseline (3,000–12,000 cells/mm3) were followed during mean follow up 7.5±3.8 years for CAD....
Most studies on the prevalence of flexible pes planus (FPP) have been conducted in pediatric populations and older adults. There is limited comparable information these parameters for adolescent age group. The purpose this study was to report FPP its association with body mass index (BMI), height, gender among healthy fit adolescents.The data were derived from a medical database containing records 17-year-old males females before their recruitment into mandatory military service. Information...
OBJECTIVE Diabetes is a risk factor for an accelerated rate of cognitive decline and dementia. However, the relationship between function subsequent development diabetes unclear. RESEARCH DESIGN AND METHODS We conducted historical-prospective cohort study merging data collected at premilitary recruitment assessment with information Staff Periodic Examination Center Israeli Army Medical Corps. Included were men aged 25 years or older without history beginning follow-up available regarding...
Abstract Background and Aims: The increasing prevalence of adolescent obesity affects adult health. We investigated the association overweight with colorectal cancer incidence in a large cohort males. Methods: Body mass index (BMI) was measured 1.1 million Jewish Israeli males who underwent general health examination at ages 16 to 19 between 1967 2005. Overweight defined as BMI ≥ 85th percentile standard U.S. distribution adolescence. Colorectal identified by linkage Israel National Cancer...
This study examined the association between body mass index (BMI) in late adolescence and risk of colon rectal cancer.This analyzed a cohort 1,087,358 Jewish men 707,212 women who underwent health examinations at ages 16 to 19 years 1967 2002 were followed by linkage national cancer registry up 2012. Cox regression was used estimate hazard ratios (HRs) for according age- sex-adjusted BMI percentiles from US Centers Disease Control Prevention (overweight, 85th percentile <95th percentile;...
Gestational hyperglycemia is associated with deleterious neonatal outcomes, but long-term risks for offspring obesity are less clear. We estimated the odds adolescent overweight and among mothers gestational glucose intolerance.In a mother-offspring historical cohort, Israel military conscription data set was linked to large health maintenance organization. Included were women who evaluated at adolescence underwent two-step diabetes screening (mean age, 31 years) 50-g challenge test (GCT),...
<p dir="ltr">Objective Assessing diabetes risk in adulthood among adolescents with isolated glucosuria. Research Design and Methods Included were (16-19 years) examined before military service between 1993-2015. Data linked the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function glucose tolerance tests. Cox models applied. Results The study included 1,611,467 adolescents, of whom 755 (0.05%) had latter group a higher proportion males (75% vs...
<p dir="ltr">Objective Assessing diabetes risk in adulthood among adolescents with isolated glucosuria. Research Design and Methods Included were (16-19 years) examined before military service between 1993-2015. Data linked the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function glucose tolerance tests. Cox models applied. Results The study included 1,611,467 adolescents, of whom 755 (0.05%) had latter group a higher proportion males (75% vs...
Hemorrhage is the primary cause of preventable death in both military and civilian trauma cases, effective therapeutic options are limited. Activation Protein Kinase C epsilon (PKC-ε) was shown to have a protective role ischemia–reperfusion injury models. Thus, we evaluated effects PKC-ε activator peptide swine model controlled hemorrhagic shock. Controlled hemorrhage induced 25 Sus Domesticus female pigs by blood withdrawal. Fifteen animals were treated with (3 mg/kg IM) five minutes...