A5066491869- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Laser Applications in Dentistry and Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Trauma and Injuries
- Electrolyte and hormonal disorders
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Ultrasound in Clinical Applications
- COVID-19 Clinical Research Studies
- Blood transfusion and management
- Anesthesia and Neurotoxicity Research
- Climate Change and Health Impacts
- Pleural and Pulmonary Diseases
- Disaster Response and Management
- Thermoregulation and physiological responses
- Cardiovascular and exercise physiology
- Injury Epidemiology and Prevention
Israel Defense Forces Medical Corps
2017-2025
Hebrew University of Jerusalem
2009-2025
Hadassah Medical Center
2018-2025
University Medical Center
2024
GTx (United States)
2020
Wolfson Medical Center
2020
Tel Aviv University
2020
Hadassah Academic College
2020
Abstract Repeated blood pressure (BP) measurements allow better control of hypertension. Current rely on cuff-based devices. The aim the present study was to compare BP using a novel cuff-less photoplethysmography-based device standard sphygmomanometer device. Males and females were recruited from within general population who arrived at public screening station. One two taken each sphygmomanometer-based Devices considered equal if mean difference between paired below 5 mmHg Standard...
Diuretics are a mainstay therapy for congestive heart failure (CHF); however, over one-third of patients develop diuretic resistance. Second-generation artificial intelligence (AI) systems introduce variability into treatment regimens to overcome the compensatory mechanisms underlying loss effectiveness diuretics. This open-labeled, proof-of-concept clinical trial sought investigate ability improve resistance by implementing algorithm-controlled therapeutic regimens.Ten CHF with were...
Background: Currently-used tools for early recognition of clinical deterioration have high sensitivity, but with low specificity and are based on infrequent measurements. We aimed to develop a pre-symptomatic real-time detection warning tool potential patients' multi-parameter score (MPRT-WS). Methods: A total more than 2 million measurements were collected, pooled, analyzed from 521 participants, which 361 patients in general wards defined at high-risk 160 healthy participants allocation as...
Hemorrhage is the primary cause of preventable death in both military and civilian trauma cases, effective therapeutic options are limited. Activation Protein Kinase C epsilon (PKC-ε) was shown to have a protective role ischemia–reperfusion injury models. Thus, we evaluated effects PKC-ε activator peptide swine model controlled hemorrhagic shock. Controlled hemorrhage induced 25 Sus Domesticus female pigs by blood withdrawal. Fifteen animals were treated with (3 mg/kg IM) five minutes...
Personal protective equipment (PPE) is crucial for infection prevention and effective only when worn correctly consistently. Health organizations often use education or inspections to mitigate non-compliance, but these are costly have limited success. This study developed a novel on-device, AI-based computer vision system monitor healthcare worker PPE adherence in real time. Using custom-built image dataset of 7142 images 11 participants wearing various combinations (mask, gloves, gown), we...
Ambulatory blood pressure monitoring (ABPM) using cuff-based devices is used for diagnosis and treatment of hypertension. Technical limitations, low compliance, complex procedures limit their use. The aim the present study was to test accuracy a new photoplethysmography-based, wearable device (Wrist-monitor) as compared with standard ABPM device.Twenty-four-hour (24H) performed in parallel both on volunteers aged 18-65 years, while documenting daily activities. Level comfort activity...
Background: Continuous blood pressure (BP) measurement in intensive care units is based on arterial line (AL) transducers, sometimes associated with clinical complications. Our objective was to evaluate continuous BP measurements obtained from a non-invasive, wireless photoplethysmography (PPG)-based device using two distinct configurations (wristwatch and chest-patch monitors) compared an AL. Methods: In this prospective evaluation study, comparison of the PPG-based devices AL conducted 10...
Abstract Accurate and continuous monitoring of critically ill patients is frequently achieved using invasive catheters, which technically complex. Our purpose was to evaluate the validity accuracy a photoplethysmography (PPG)-based remote device compared methods arterial line (AL) Swan-Ganz (SG) catheters in swine model controlled hemorrhagic shock. Following baseline phase, shock induced 11 pigs by bleeding 35% their blood volume, followed post-bleeding follow-up phase. Animals were...
Cardiac output (CO) measurements in the ICU are usually based on invasive techniques, which technically complex and associated with clinical complications. This study aimed to compare CO obtained from a noninvasive photoplethysmography-based device pulse contour cardiac patients.Observational, prospective, comparative trial.Single-center general ICU.Patients admitted monitored using as per decision of attending physician.Parallel monitoring chest patch while medical team was blinded values...
Vital signs obtained by photoplethysmography-based devices might be influenced subcutaneous fat and skin color. This observational comparison study aimed to test the accuracy of blood pressure (BP) measurements between a device cuff-based BP in ambulatory individuals, coming for routine checkup. Systolic (SBP) diastolic (DBP) were stratified based on sex, BMI (<25; 25 ≤BMI<30; 30 ≤kg/m2), color (types 1-3 4-6 Fitzpatrick scale). A total 1548 analyzed. Correlations SBP DBP among males/females...
COVID-19 exerts deleterious cardiopulmonary effects, leading to a worse prognosis in the most affected. This retrospective multi-center observational cohort study aimed analyze trajectories of key vitals amongst hospitalized patients using chest-patch wearable providing continuous remote patient monitoring numerous vital signs. The was conducted five isolation units. A total 492 were included final analysis. Physiological parameters measured every 15 min. More than 3 million measurements...
Early detection of influenza may improve responses against outbreaks. This study was part a clinical assessing the efficacy novel vaccine, aiming to discover distinct, highly predictive patterns pre-symptomatic illness based on changes in advanced physiological parameters using wearable sensor. Participants were frequently monitored 24 h before and for nine days after challenge. Viral load measured daily, self-reported symptoms collected twice day. The Random Forest classifier model used...
We describe the first case report of a patient with COVID19 infection and metastatic breast cancer, while on systemic therapy CDK4/6 inhibitor. The had unique disease course, characterized delayed symptomatology. highlights novel findings stress careful extended follow-up during in patients taking biologic therapies affecting immune system.
Rupture of Abdominal aortic aneurysm (AAA) is among the 15 leading causes death after age 65. Using high frequency ultrasound, we showed that photobiomodulation (PBM) prevents formation and progression AAA in angiotensin-II (Ang-II)-infused, apolipoprotein-e-deficient mouse model. In current study report while challenge porcine Smooth Muscle Cells (SMCs) with Ang-II (1 μM) resulted a marked decay mitochondrial membrane potential (MitMP) vs non-challenged cells, treatment PBM (continuous...
Intradialytic hypotension (IDH) is a severe complication of hemodialysis (HD) with significant impact on morbidity and mortality. In this study, we used wearable device for the continuous monitoring hemodynamic vitals to detect changes during HD attempted identify IDH. End-stage kidney disease patients were continuously monitored 15 min before starting session until after completion session, measuring heart rate (HR), noninvasive cuffless systolic diastolic blood pressure (SBP DBP), stroke...
Background and Aims: Acetaminophen (APAP) HMG-CoA reductase inhibitors are common causes of drug-induced liver injury (DILI). This study aimed to determine the ability reduce APAP- statins-mediated by using formulations that combine glycosphingolipids vitamin E. Methods: Mice were injected with APAP or statins treated before after β-glucosylceramide (GC), without followed for changes in enzymes, histology, hepatic expression JNK, STAT3 caspase 3, as well intrahepatic natural killer T cells...
Background Respiratory rate (RR) is used for the diagnosis and management of medical conditions can predict clinical changes. Heavy workload, understaffing, errors related to poor recording make it underutilized. Wearable devices may facilitate its use. Methods RR measurements using a wearable photoplethysmography-based monitor were compared with grade in complementary scenarios: Study one included comparison capnograph 35 healthy volunteers; two ventilator 18 ventilated patients; three 92...