A5024858841- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Disease and Transplantation
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Pelvic floor disorders treatments
- Lysosomal Storage Disorders Research
- Intestinal Malrotation and Obstruction Disorders
- Adolescent and Pediatric Healthcare
- Liver Diseases and Immunity
- Gastrointestinal motility and disorders
- Advanced MRI Techniques and Applications
Hadassah Medical Center
2011-2023
Rambam Health Care Campus
2023
Shaare Zedek Medical Center
2006-2022
Hebrew University of Jerusalem
2012-2022
Massachusetts General Hospital
2016-2021
Harvard University
2016-2021
Zero to Three
2018
Keimyung University
2016
Complejo Hospitalario de Salamanca
2016
Instituto de Salud Carlos III
2016
BACKGROUND Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and endometrial (EC). Screening all CRCs for LS currently recommended, but screening ECs inconsistent. The objective this study was to determine added value both CRC EC tumors in same population. METHODS A prospective, immunohistochemistry (IHC)‐based program patients with newly diagnosed initiated 2011 2013, respectively, at 2 centers (primary tertiary). Genetic testing recommended those who had...
The older patient group with inflammatory bowel diseases (IBD) is particularly vulnerable to consequences of disease and therapy-related side effects but little known about the best treatment options in this population.To compare safety efficacy tumor necrosis factor α antagonist (anti-TNF) or vedolizumab (VDZ) patients IBD >60 years age.This retrospective study included Crohn's (CD) ulcerative colitis (UC) initiating anti-TNF VDZ therapy ≥60 age at three sites. We examined occurrence...
Antitumor necrosis factor antibodies are widely used in the treatment of autoimmune diseases. We describe occurrence hepatitis a patient treated with adalimumab, fully human IgG antibody against tumor factor, for psoriatic arthritis. The made full recovery after discontinuation adalimumab and steroids. This is first reported case adalimumab-induced hepatitis.
Nonalcoholic steatohepatitis (NASH) is considered to be part of the nonalcoholic fatty liver disorders and its incidence increasing. Imm124-E (Immuron Ltd, Melbourne, Australia), containing hyperimmune bovine colostrum, has been shown exert an immunomodulatory effect alleviate target organ damage in animal models NASH. The aim our study was determine safety efficacy oral administration patients with insulin resistance NASH.In open-label trial, ten biopsy-proven NASH were orally treated for...
Insulin resistance and metabolic syndrome are chronic inflammatory conditions that lead to hepatic injury non-alcoholic steatohepatitis (NASH). Bovine colostrum has therapeutic effects in a variety of infections. However its effectiveness NASH was never studied. Natural killer T (NKT) cells have been shown be associated with some the pathological abnormalities accompanying leptin-deficient (ob/ob) mice. In present study, we used hyperimmune bovine treat insulin also assessed on NKT cells. We...
<b>Background and study aims:</b> The traditional endoscopic treatment for gastric antral vascular ectasia (GAVE) is argon plasma coagulation, but results are not always positive. Radiofrequency ablation (RFA) a new therapy that may be an attractive option the of GAVE. aim this was to assess efficacy safety RFA <b>Patients methods:</b> This open-label, retrospective, case series study. main outcome measures were number red blood cell (RBC) packs transfused (transfusion requirement)...
<b>Background and study aims: </b>The main endoscopic therapy for radiation proctitis is argon plasma coagulation (APC); however treatment not always successful. Radiofrequency ablation (RFA) a possible but data are scarce. The aim of this was to report on the safety efficacy RFA in proctitis. <b>Patients methods:</b> This an open-label, retrospective, multicenter patients with chronic hemorrhagic who were treated RFA. Data included three-item symptom score, number packed red blood cell...
Background: Capsule endoscopy (CE) is often used to investigate small bowel Crohn's disease (CD).Aim: The aim of this study prospectively assess the value fecal calprotectin and lactoferrin predict CE findings.Patients methods: Sixty-eight consecutive patients that were referred for included. Stool samples blood collected relevant parameters. Correlation between markers findings was assessed receiver operating characteristic (ROC) curves built determine predictive values diagnosis...
Insulin resistance (IR) plays an important role in the pathogenesis of diabetes and non-alcoholic fatty liver disease (NAFLD). Current methods for insulin detection are cumbersome, or not sensitive enough early follow-up. The BreathID system can continuously analyse breath samples real-time at point-of-care. Here we determined efficacy using 13C-Glucose test (GBT) evaluation resistance.Twenty healthy volunteers were orally administered 75 mg 13C-glucose 1-13C. An oral glucose tolerance...
Lynch syndrome is the most common cause of hereditary colon cancer but also associated with gastric cancer.1 Interestingly, was a distinguishing feature original pedigree described in 1913.2 Currently, standardised incidence ratio (SIR) for estimated to be 3.4.3 Among 255 gene-positive patients followed prospectively our Hereditary Gastrointestinal Cancer programme, 7 (2.7%, 95% CI 1.3% 5.7%) were diagnosed at median age 55 years. Six carried an MSH2 mutation, five women and exhibited...
AIM:To assess the role of 13 C-methacetin breath test (MBT) in patients with acute liver disease. METHODS:Fifteen severe disease from diverse etiologies were followed-up C-MBT during phase their illnesses (range 3-116 d after treatment).Patients fasted for 8 h and ingested 75 mg methacetin prior to MBT.We compared results standard clinical assessment, serum enzymes, synthetic function, scores. RESULTS:Thirteen recovered two died.In that recovered, MBT parameters improved parallel...
Gaucher disease is associated with increased red blood cell (RBC) aggregation, but the pathophysiological significance of this phenomenon and its correlation manifestations are unclear. RBC aggregation was evaluated in 43 patients 53 healthy controls. Dynamic examined a narrow-gap flow chamber at varying shear stress. Compared controls, by 25%. Comparison autologous plasma dextran (500 kDa) showed an increase both plasma-dependent (extrinsic) -independent (intrinsic) aggregation. Subgroup...
The development and characteristics of inflammatory bowel disease (IBD) in Ethiopian Jewish immigrants to Israel were investigated.A case-control study was conducted 7 tertiary care hospitals Israel. Patients origin with IBD >6 months included. Time onset after immigration age at diagnosis recorded. Randomly chosen patients Ashkenazi served as controls. Demographics clinical parameters compared between the 2 cohorts.Thirty-two 33 IBD. Crohn's (CD) more prevalent than ulcerative colitis (UC)...
Background and Aims: Acetaminophen (APAP) HMG-CoA reductase inhibitors are common causes of drug-induced liver injury (DILI). This study aimed to determine the ability reduce APAP- statins-mediated by using formulations that combine glycosphingolipids vitamin E. Methods: Mice were injected with APAP or statins treated before after β-glucosylceramide (GC), without followed for changes in enzymes, histology, hepatic expression JNK, STAT3 caspase 3, as well intrahepatic natural killer T cells...