A5054806365- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Hippo pathway signaling and YAP/TAZ
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- Cell Image Analysis Techniques
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Viral Infections and Vectors
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
- Microbial Inactivation Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Cell Adhesion Molecules Research
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
Weizmann Institute of Science
2017-2025
Tel Aviv University
2013-2024
London School of Hygiene & Tropical Medicine
2021
Mwanza Intervention Trials Unit
2021
National Institute for Medical Research
2021
University of London
2021
Sheba Medical Center
2013-2018
Rabin Medical Center
2017
King's College London
2016
Centro Cardiologico Monzino
2016
Background: Ischemic heart diseases are leading causes of death and reduced life quality worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), a large number patients with MI develop chronic failure over time. We previously reported that fragment the extracellular matrix protein agrin promotes cardiac regeneration in adult mice. Methods: To test therapeutic potential preclinical porcine model, we performed ischemia–reperfusion...
Macrophages and Wnt proteins (Wnts) are independently involved in cardiac development, response to injury, repair. However, the role of macrophage-derived Wnts healing repair myocardial infarction (MI) is unknown. We sought determine macrophage infarct repair.We show that pathway activated after MI mice. Furthermore, we demonstrate isolated macrophages express distinct components a source noncanonical MI. To effect on repair, evaluated mice lacking essential transporter Wntless (Wls) myeloid...
Biocompatible fluorescent agents are key contributors to the theranostic paradigm by enabling real-time in vivo imaging. This study explores optical properties of phenylenediamine carbon dots (CDs) and demonstrates their potential for fluorescence imaging cells brain blood vessels. The nonlinear absorption cross-section CDs was measured achieved values near 50 Goeppert-Mayer (GM) units with efficient excitation 775-895 nm spectral range. Mesoporous vaterite nanoparticles were loaded examine...
Little is known about the potentially unfavorable effects of mesenchymal stromal cell (MSC) activation on heart. MSCs can respond to tissue injury by anti- or proinflammatory activation. We aimed study potential negative interaction between left ventricular dysfunction (LVD) and MSC activation.We isolated from cardiac subcutaneous fat tissues mice with LVD 28 days after myocardial infarction sham operation. To evaluate effect MSCs, we characterized in vitro. Subsequently, injected saline...
Background Irreversible electroporation (IRE) is a non-thermal cell ablation approach that induces selective damage to membranes only. The purpose of the current study was evaluate and optimize its use for in-vivo myocardial decellularization. Methods Forty-two Sprague-Dawley rats were used compare seven different IRE protocols with anterior infarction damage. An open thoracotomy model used, two-needle electrodes in ventricular wall. included combinations pulse lengths (70 vs. 100 μseconds),...
Human mesenchymal stromal cells (hMSCs) from adipose cardiac tissue have attracted considerable interest in regard to cell-based therapies. We aimed test the hypothesis that hMSCs heart and epicardial fat would be better for infarct repair.We isolated grew patients with ischemic disease 4 locations: fat, pericardial subcutaneous right atrium. Significantly, atrium secreted highest amounts of trophic inflammatory cytokines, while lowest. Relative expression inflammation- fibrosis-related...
Brain metastases are prevalent in various types of cancer and often terminal, given the low efficacy available therapies. Therefore, preventing them is utmost clinical relevance, prophylactic treatments perhaps most efficient strategy. Here, we show that systemic administration a toll-like receptor (TLR) 9 agonist, CpG-C, effective against brain metastases. Acute chronic CpG-C reduced tumor cell seeding growth three models mice, including metastasis human mouse lung cancer, spontaneous...
Nature-inspired nanosized formulations based on an imageable, small-sized inorganic core scaffold, which biomolecules are assembled to form nanobiomimetics, hold great promise for both early diagnostics and developed therapeutics. Nevertheless, the fabrication of nanobiomimetics that allow noninvasive background-free mapping pathological events with improved sensitivity, enhanced specificity, multiplexed capabilities remains a major challenge. Here, we introduce paramagnetic...
MicroRNAs (miRNAs, miR) are endogenous short RNA sequences that regulate a wide range of physiological and pathophysiological processes. Several miRNAs control the formation new blood vessels either by increasing or inhibiting angiogenesis. Here, we investigated possible role miR-106b∼25 cluster in postnatal neovascularization regulation angiogenic properties adult bone marrow-derived stromal cells.To study effect deletion on neovascularization, used knockout (KO) mouse model. After inducing...
The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins-4 -13 are anti-inflammatory type-2 cytokines, signaling via the common interleukin-13 receptor α1 chain interleukin-4 receptor. of heart is unknown.We analyzed samples from human donors (n=136) patients with end-stage failure (n=177). We found that present myocardium and, together complementary Il4ra, significantly downregulated hearts failure. Next, we showed Il13ra1-deficient mice develop...
Background Acute MI induces leptin expression in the heart, however role of myocardial cardiac ischemia and reperfusion (IR) remains unknown. To shed light on effects elevated levels myocardium, we overexpressed assessed local remodeling function this context. Methods results Cardiac overexpression was stimulated mice undergoing IR by a single intraperitoneal injection antagonist (LepA). All exhibited normal pattern body weight gain. A rapid, long-term upregulation mRNA demonstrated adipose,...