A5001176337- Venomous Animal Envenomation and Studies
- Ubiquitin and proteasome pathways
- Catalytic Processes in Materials Science
- Ion channel regulation and function
- Marine Invertebrate Physiology and Ecology
- Yersinia bacterium, plague, ectoparasites research
- Nicotinic Acetylcholine Receptors Study
- Advanced Combustion Engine Technologies
- CO2 Reduction Techniques and Catalysts
- Colorectal Cancer Screening and Detection
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Organometallic Complex Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Forensic Anthropology and Bioarchaeology Studies
- Hippo pathway signaling and YAP/TAZ
- Bone and Dental Protein Studies
- Catalysis and Oxidation Reactions
- Catalysts for Methane Reforming
- Microbial Natural Products and Biosynthesis
- Viral gastroenteritis research and epidemiology
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Marine Ecology and Invasive Species
- SARS-CoV-2 and COVID-19 Research
Weizmann Institute of Science
2017-2025
Rush University Medical Center
2024
Columbia University Irving Medical Center
2024
NYU Langone Health
2015-2024
Assuta Medical Center
2023
Bayer (France)
2022
The University of Queensland
2011-2019
University of Haifa
2014-2017
University of Tübingen
2017
New York University
2014-2016
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of ongoing disease 2019 (COVID-19) pandemic1. To understand pathogenicity and antigenic potential SARS-CoV-2 to develop therapeutic tools, it essential profile full repertoire its expressed proteins. The current map coding capacity based on computational predictions relies homology with other coronaviruses. As protein complement varies among coronaviruses, especially in regard variety accessory proteins, crucial...
The respiratory and intestinal tracts are exposed to physical biological hazards accompanying the intake of air food. Likewise, vasculature is threatened by inflammation trauma. Mucin glycoproteins related von Willebrand factor guard vulnerable cell layers in these diverse systems. Colon mucins additionally house feed gut microbiome. Here, we present an integrated structural analysis mucin MUC2. Our findings reveal shared mechanism which complex macromolecules responsible for blood clotting,...
Nematocytes, the stinging cells of cnidarians, are most evolutionarily ancient venom apparatus. These nanosyringe-like weaponry systems reach pressures approximately 150 atmospheres before discharging and punching through outer layer prey or predator at accelerations more than 5 million g, making them one fastest biomechanical events known. To gain better understanding function complex, phylum-specific nematocyst organelle, its payload, we compared soluble nematocyst's proteome from sea...
Messenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions are determined by their constant region subclasses and glycosylation patterns, but role in vaccine efficacy is unclear. Moreover, whether vaccination induces antibodies similar to those patients remains unknown. We analyze BNT162b2 vaccine-induced IgG subclass distribution Fc patterns potential drive function via Fcγ receptors...
We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) tumor suppressor that promotes death through specifically antagonizing XIAP (X-linked inhibitor of apoptosis). and Bcl-2 reside at outer mitochondrial membrane in living cells. Upon apoptotic induction, brings into ternary complex, allowing promote ubiquitylation degradation Bcl-2. binding involves BH3 domain Lysine 17 serves as main acceptor for...
Owing to the extensive development of drug resistance in pathogens against available antibiotic arsenal, antimicrobial is now an emerging major threat public healthcare. Anti-virulence drugs are a new type therapeutic agent aiming at virulence factors rather than killing pathogen, thus providing less selective pressure for evolution resistance. One promising example this concept targets bacterial quorum sensing (QS), because QS controls many responsible infections. Marine sponges and their...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of ongoing Coronavirus disease 19 (COVID-19) pandemic 1,2 . In order to understand SARS-CoV-2 pathogenicity and antigenic potential, develop diagnostic therapeutic tools, it essential portray full repertoire its expressed proteins. The coding capacity map currently based on computational predictions relies homology other coronaviruses. Since coronaviruses differ in their protein array, especially variety...
Ortholog protein complexes are responsible for equivalent functions in different organisms. However, during evolution, each organism adapts to meet its physiological needs and the environmental challenges imposed by niche. This selection pressure leads structural diversity complexes, which often difficult specify, especially absence of high-resolution structures. Here, we describe a multilevel experimental approach based on native mass spectrometry (MS) tools elucidating preservation...
Domains known as von Willebrand factor type D (VWD) are found in extracellular and cell-surface proteins including factor, mucins, various signaling molecules receptors. Many VWD domains have a glycine-aspartate-proline-histidine (GDPH) amino-acid sequence motif, which is hydrolytically cleaved post-translationally between the aspartate (Asp) proline (Pro). The Fc IgG binding protein (FCGBP), intestinal mucus secretions other environments, contains 13 domains, 11 of GDPH cleavage site. In...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoreduction of carbon dioxide to its radical anion by nickel cluster [Ni3(.mu.3-I)2(dppm)3]: formation two carbon-carbon bonds via addition cyclohexeneDavid A. Morgenstern, Rebecca E. Wittrig, Phillip Fanwick, and Clifford P. KubiakCite this: J. Am. Chem. Soc. 1993, 115, 14, 6470–6471Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July...
Raney nickel can be plated with a high loading of copper (28%) to produce novel copper−nickel catalyst, which retains Raney-type structure. A simple two-step aqueous procedure was used. The catalyst exhibits activity for low-temperature (250−300 °C) reforming ethanol methane, carbon monoxide, and hydrogen. Stable over 400 h achieved no detectable methanation. is significantly less active methanol has low water−gas shift activity. kinetics fit model in dehydrogenated acetaldehyde first-order...
Although it has been established that all toxicoferan squamates share a common venomous ancestor, remained unclear whether the maxillary and mandibular venom glands are evolving on separate gene expression trajectories or if they remain under shared genetic control. We show identical transcripts simultaneously expressed not only in glands, but also enigmatic snake rictal gland. Toxin molecular frameworks recovered this study were three-finger toxin (3FTx), CRiSP, crotamine (beta-defensin),...
Protein complexes often represent an ensemble of different assemblies with distinct functions and regulation. This increased complexity is enabled by the variety protein diversification mechanisms that exist at every step biosynthesis pathway, such as alternative splicing post transcriptional translational modifications. The resulting variation in subunits can generate compositionally assemblies. These forms a single complex may comprise functional variances enable response adaptation to...
Molecular omics studies have identified proteins related to cognitive resilience but unrelated Alzheimer disease and disease-related dementia (AD/ADRD) pathologies. Posttranslational modifications of with glycans can modify protein function. In this study, we glycopeptiforms associated resilience.
Abstract Proteasomes are essential for protein degradation and maintaining cellular balance, yet their roles in extracellular fluids not well understood. Our study investigates the freely circulating proteasome blood, to uncover its unique molecular characteristics, compared intracellular counterparts. Using a transgenic mouse model, mass spectrometry, biochemical tools, we show that predominant serum is free uncapped 20S particle, which seems assemble intracellularly before entering...
The proteasome is a multisubunit degradation machinery that essential for maintaining protein homeostasis by breaking down unnecessary or damaged proteins into peptides. While most of these peptides are further processed amino acids, subset evades complete and plays key roles in biological processes such as antigen presentation, signaling, apoptosis. However, the variability peptide lengths diverse composition proteasomes make their comprehensive identification characterization particularly...
Alzheimer's disease (AD) dementia is characterized by significant molecular and phenotypic heterogeneity, which confounds its mechanistic understanding, diagnosis, effective treatment. In this study, we harness the most comprehensive dataset of paired ante-mortem blood omics, clinical, psychological, post-mortem brain multi-omics data neuroimaging to extensively characterize translate taxonomy AD living individuals. First, utilizing a integration eight complementary layers from (N = 1,189),...