A5010532097- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Balance, Gait, and Falls Prevention
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Effects of Exercise
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Cardiovascular Health and Disease Prevention
- Frailty in Older Adults
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Risk Factors
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Health disparities and outcomes
- Sports injuries and prevention
- Optical Imaging and Spectroscopy Techniques
- Nursing Roles and Practices
- Pharmacovigilance and Adverse Drug Reactions
- Drug-Induced Adverse Reactions
- Motor Control and Adaptation
Rush University Medical Center
2021-2025
Rush University
2021-2025
Barnes Hospital
2022
Harvard University
2016-2021
VA Boston Healthcare System
2016-2021
Geriatric Research Education and Clinical Center
2017-2021
Purdue University West Lafayette
2012-2021
Hebrew SeniorLife
2017-2019
Beth Israel Deaconess Medical Center
2016-2019
University of Milan
2019
Long-term neurological damage as a result of head trauma while playing sports is major concern for football athletes today. Repetitive concussions have been linked to many disorders. Recently, it has reported that repetitive subconcussive events can be significant source accrued damage. Since experience hundreds hits during single season, utmost importance understand their effect on brain health in the short and long term. In this study, resting-state functional magnetic resonance imaging...
With growing evidence of long-term neurological damage in individuals enduring repetitive head trauma, it is critical to detect lower-level accumulation for the early diagnosis injury at-risk populations. Proton magnetic resonance spectroscopic scans dorsolateral prefrontal cortex and primary motor were collected from high school American (gridiron) football athletes, prior during their competition seasons. Although no concussions diagnosed, significant metabolic deviations baseline...
Sub-concussive head impacts are identified as a source of accrued damage. Football athletes experience hundreds such blows each season. Resting state functional magnetic resonance imaging was used to prospectively study changes in Default Mode Network connectivity for clinically asymptomatic high school football athletes. Athletes exhibited short-term relative baseline and across sessions.
Magnetic resonance spectroscopy and helmet telemetry were used to monitor the neural metabolic response repetitive head collisions in 25 high school American football athletes. Specific hit characteristics determined highly predictive of alterations, suggesting that sub-concussive blows can produce biochemical changes potentially lead neurological problems.
Reward and motivation have powerful effects on cognition brain activity, yet it remains unclear how they affect sustained cognitive performance. We recently shown that a variety of motivators improve accuracy reduce variability during attention. In the current study, we investigate neural activity in task-positive networks supports these attention improvements. Participants performed gradual-onset continuous performance task with alternating motivated (rewarded) unmotivated (unrewarded)...
Abstract Several studies have examined how individual differences in sustained attention relate to functional brain measures (e.g., connectivity), but far fewer ability, or cognition general, cortical structure. Functional magnetic resonance imaging meta‐analyses and patient work highlighted that frontoparietal regions, lateralized the right hemisphere, are critical for attention, though recent implicates a broader expanse of regions. The current study sought determine if where variation...
Changes in cerebral blood flow velocity (CBF) response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) be reduced slow walkers. However, it is unknown whether task-related ΔCBF associated with neural activity specific brain regions, as measured blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI). We assessed the regional changes middle artery (MCA) an executive and walking speed 67 community-dwelling older...
Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biologic mechanisms these associations remain largely unknown. To examine whether one or more multi-omic brain molecular subtypes is associated with and/or life. Two cohort-based studies; Religious Orders Study (ROS) Rush Memory Aging Project (MAP), both ongoing longitudinal clinical pathological studies that began enrollment 1994 1997....
ABSTRACT Alzheimer’s disease (AD) dementia is characterized by significant molecular and phenotypic heterogeneity, which confounds its mechanistic understanding, diagnosis, effective treatment. In this study, we harness the most comprehensive dataset of paired ante-mortem blood omics, clinical, psychological, post-mortem brain multi-omics data neuroimaging to extensively characterize translate taxonomy AD living individuals. First, utilizing a integration eight complementary layers from (N =...
<title>Abstract</title> Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biologic mechanisms these associations remain largely unknown. In this study we examined whether pseudotime, representing molecular distance from no cognitive impairment (NCI) to dementia, three distinct multi-omic brain subtypes dementia 3 omic pathways NCI differentially associated with factors. Participants...
Recent evidence of short-term alterations in brain physiology associated with repeated exposure to moderate intensity subconcussive head acceleration events (HAEs), prompts the question whether these represent an underlying neural injury. A retrospective analysis combining counts experienced HAEs and longitudinal diffusion-weighted imaging explored greater incident mechanical forces was traditional diffusion-based measures injury—reduced fractional anisotropy (FA) increased mean diffusivity...
Progressive parkinsonism is common in older adults without a diagnosis of Parkinson disease and associated with adverse health outcomes, but its pathologic basis controversial.To examine if the burden cerebral white matter hyperintensity (WMH), manifestation cerebrovascular pathologies, rate progressive parkinsonism.This community-based cohort study included participants recruited 3 ongoing cohorts that began enrollment 1994, 1997, 2004. Prior to death, were observed for mean 7.5 years,...
Abstract Introduction Interpersonal early life trauma (I‐ ELT ) is associated with a myriad of functional impairments in adulthood, increased risk drug addiction, and neuropsychiatric disorders. While deficits emotional regulation amygdala functioning are well characterized, general cognitive have also been documented. However, the neural underpinnings dysfunction adults history I‐ potential relationship between amygdala‐based connectivity behavioral performance currently poorly understood....
Metabolic syndrome (MetS), the presence of three or more cardiovascular risk factors, has been associated with subtle and diffuse neural compromise but not consistently cognitive dysfunction. Sustained attention is a fundamental operation that relies on multiple brain networks impaired in broad array neurologic conditions. We examined whether well-validated measure sustained would be sensitive to vascular risk, as compared standard neuropsychological measures executive functioning.We...
Abstract Background In older adults, compromised white matter tract integrity within the brain has been linked to impairments in mobility. We contend that poorer disrupts mobility by altering processing of sensorimotor and cognitive attentional resources neural networks. The richness information a given network can be quantified calculating complexity resting-state functional MRI time series. hypothesized (i) adults with lower complexity, specifically sensorimotor, executive, attention...
While walking was once thought to be a highly automated process, it requires higher-level cognition with older age. Like other cognitive tasks, also becomes further challenged increased load (e.g., the addition of an unrelated dual task) and often results in poorer performance slower speed). It is not well known, however, how intrinsic neural network communication relates speed, nor this "cost" gait performance; i.e., "dual-task cost". The current study investigates relationship between...
Although cognitive decline has previously been associated with mobility limitations and frailty, the relationship between sustained attention gait speed is incompletely characterized. To better quantify specificity of association, we examined extent to which this unique rather than accounted for by executive functioning physical health characteristics. 58 middle-to-older-aged community-dwelling adults without overt evidence impairment (45–90 years old; 21 females) participated in study. Each...
Abstract While there has been a proliferation of neuroimaging studies on cognitive decline in older non‐Hispanic White adults, is dearth knowledge regarding correlates Black adults. Resting‐state functional approaches may be particularly sensitive to early decline, but are no that we know apply this approach examining associations brain function cognition We investigated the association with whole‐brain voxel‐wise connectivity hippocampus, key region functionally implicated Alzheimer's...
Hand trauma is the most frequently treated injury in emergency departments, but presently there a crisis of insufficient coverage. This study evaluates discrepancy emergent and elective hand care trends based on socioeconomic factors state Tennessee.We identified 119 hospitals Tennessee that contained operating room facilities. Of these, 111 participated survey to determine availability surgery. Wilcoxon rank-sum test or permutation chi-square logistic regression were used analyze reported...