A5063494067- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- COVID-19 and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury and Neurovascular Disturbances
- Behavioral Health and Interventions
- Decision-Making and Behavioral Economics
- Long-Term Effects of COVID-19
- Color perception and design
- Neural and Behavioral Psychology Studies
- Mitochondrial Function and Pathology
- Vaccine Coverage and Hesitancy
- High Altitude and Hypoxia
- Substance Abuse Treatment and Outcomes
- Behavioral and Psychological Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Misinformation and Its Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Effects of Exercise
- COVID-19 epidemiological studies
- Stroke Rehabilitation and Recovery
Purdue University West Lafayette
2017-2024
University of Cincinnati
2022-2024
Northwestern University
2020-2022
Although the mental health impacts of COVID-19 on general population have been well studied, studies long-term infected individuals are relatively new. To date, depression, anxiety, and neurological symptoms associated with post-COVID-19 syndrome (PCS) observed in months following recovery. Suicidal thoughts behavior (STB) also preliminarily proposed as sequelae COVID-19.We asked 3 questions. First, do participants reporting a history diagnosis or close relative having severe score higher...
Despite COVID-19 vaccine mandates, many chose to forgo vaccination, raising questions about the psychology underlying how judgment affects these choices. Research shows that reward and aversion judgments are important for vaccination choice; however, no studies have integrated such cognitive science with machine learning predict uptake.
Recent evidence of short-term alterations in brain physiology associated with repeated exposure to moderate intensity subconcussive head acceleration events (HAEs), prompts the question whether these represent an underlying neural injury. A retrospective analysis combining counts experienced HAEs and longitudinal diffusion-weighted imaging explored greater incident mechanical forces was traditional diffusion-based measures injury—reduced fractional anisotropy (FA) increased mean diffusivity...
Abstract American football has become the focus of numerous studies highlighting a growing concern that cumulative exposure to repetitive, sports-related head acceleration events (HAEs) may have negative consequences for brain health, even in absence diagnosed concussion. In this longitudinal study, functional connectivity was analyzed cohort high school athletes over single play season and compared against participants non-collision sports. Football underwent four resting-state magnetic...
Abstract The prediction of suicidal thought and behavior has met with mixed results. This study 3,476 de-identified participants (4,019 before data exclusion) quantified the four (STB) variables using a short reward/aversion judgment task limited set demographic mental health surveys. focus was to produce simple, quick objective framework for assessing STB that might be automatable, without use big data. A balanced random forest classifier performed better than Gaussian mixture model...
Reports estimate between 1.6-3.8 million sports-related concussions occur annually, with 30% occurring in youth male American football athletes. Many studies report neurophysiological changes these athletes, but the exact reasons for remain elusive. Investigation of injury mechanics highlights a need to address how player position might impact changes. Here, 55 high school athletes (20 linemen; 35 non-linemen) underwent magnetic resonance spectroscopy four times over course season—once prior...
Background Rates of depression and addiction have risen drastically over the past decade, but lack integrative techniques remains a barrier to accurate diagnoses these mental illnesses. Changes in reward/aversion behavior corresponding brain structures been identified those with major depressive disorder (MDD) cocaine-dependence polysubstance abuse (CD). Assessment statistical interactions between computational structure may quantitatively segregate MDD CD. Methods Here, 111 participants [40...
Abstract Anxiety, a condition characterized by intense fear and persistent worry, affects millions each year and, when severe, is distressing functionally impairing. Numerous machine learning frameworks have been developed tested to predict features of anxiety traits. This study extended these approaches using small set interpretable judgment variables ( n = 15) contextual (demographics, perceived loneliness, COVID-19 history) (1) understand the relationships between (2) develop framework...
Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male athletes before athletic season (Pre) after last game (Post). Samples underwent nontargeted metabolomic profiling 1131 metabolites were included for univariate, pathway enrichment, multivariate...
Abstract Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in novel demonstration of “imaging omics.” Data collected National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships 1) elevated levels miR-30d miR-92a to putamen rCBF, 2) rCBF compromised Balance scores, 3) scores microRNA (miRNA) levels. acted as...
Female athletes are under-studied in the field of concussion research, despite evidence higher injury prevalence and longer recovery time. Hormonal fluctuations caused by natural menstrual cycle (MC) or hormonal contraceptive (HC) use impact both post-injury symptoms neuroimaging findings, but relationships among hormone, symptoms, brain-based measures have not been jointly considered studies. In this preliminary study, we compared cerebral blood flow (CBF) measured with arterial spin...
The COVID-19 disease results from infection by the SARS-CoV-2 virus to produce a range of mild severe physical, neurological, and mental health symptoms. pandemic has indirectly caused significant emotional distress, triggering emergence symptoms in individuals who were not previously affected or exacerbating those with existing conditions. Emotional distress certain conditions can lead violent ideation disruptive behavior, including aggression, threatening acts, deliberate harm toward other...
Background The COVID-19 pandemic has heightened mental health concerns, but the temporal relationship between conditions and SARS-CoV-2 infection not yet been investigated. Specifically, psychological issues, violent behaviors, substance use were reported more during than before pandemic. However, it is unknown whether a prepandemic history of these increases an individual’s susceptibility to SARS-CoV-2. Objective This study aimed better understand risks underlying COVID-19, as important...
Operant keypress tasks, where each action has a consequence, have been analogized to the construct of "wanting" and produce lawful relationships in humans that quantify preferences for approach avoidance behavior. It is unknown if rating tasks without an operant framework, which can be "liking", show similar relationships. We studied three independent cohorts participants (N = 501, 506, 4,019 participants) collected by two distinct organizations, using same 7-point Likert scale rate negative...
Contact sports affect measures at multiple scales such as transcriptomics, metabolomics, brain function, and behavior, but studies have not yet studied the statistical structure of how they are integrated. This preliminary study, examining collegiate American football players, integrated across-season changes (Δ) from transcriptomic metabolomic variables (neuroinflammatory miRNAs metabolites), neuroimaging (resting-state fMRI network fingerprint similarity), virtual reality (VR)-based motor...
Research suggests contact sports affect neurological health. This study used permutation-based mediation statistics to integrate measures of metabolomics, neuroinflammatory miRNAs, and virtual reality (VR)-based motor control investigate multi-scale relationships across a season collegiate American football. Fourteen significant mediations (six pre-season, eight across-season) were observed where metabolites always mediated the statistical relationship between miRNAs VR-based ( pSobelperm≤...
Abstract Operant keypress tasks in a reinforcement-reward framework where behavior is shaped by its consequence, show lawful relationships human preference (i.e., approach/avoidance) and have been analogized to “wanting”. However, they take 20–40 min as opposed short non-operant rating tasks, which can be 3 unsupervised, thus more readily applied internet research. It unknown if each action does not analogous “liking”, similar relationships. We studied non-operant, picture-rating data from...
Purpose To improve the specific absorption rate (SAR) compression model capability in parallel transmission (pTx) MRI systems. Methods A k ‐means clustering method is proposed to group voxels with similar SAR behaviors scanned object, providing a controlled upper‐bounded estimation of peak local SARs. This and conventional virtual observation point (VOP) were tested pTx framework. The pulse design different controlling schemes was simulated using numerical human head an eight‐channel 7T coil...
Abstract This study investigated the effects of using Model Eliciting Activities that build representational fluency on cognitive processing selected cryptography concepts. The used an experimental design where in control group concepts were taught to 5 participants two forms (language and mathematics) treatment same participant four (language, mathematics, graphic concrete). Cognitive was measured Functional Magnetic Resonance Imaging (fMRI) determine brain are processed whether use MEAs...
Recent research has shown there can be detrimental neurological effects of short- and long-term exposure to contact sports. In the present study, metabolomic profiling was combined with inflammatory miRNA quantification, computational behavior virtual reality (VR) testing motor control, head collision event monitoring explore trans-omic on human across a season players collegiate American football team. We integrated permutation-based statistics mediation analyses test complex, directional...
American football has become the focus of numerous studies examining relationship between athlete brain health and sports-related exposure to repetitive head impacts. Specifically, there is growing concern that cumulative effects impacts may have negative consequences for health, even in absence a diagnosed concussion or obvious symptoms. In this longitudinal study, functional connectivity was analyzed cohort high school athletes over course single play season. Football underwent four...
We used resting state functional MRI data to investigate whether asymptomatic high school American football athletes undergo connectome (FC) changes during exposure head acceleration events (HAEs). FCs of were shown significant the season and then return their pre-season after conclusion collision activities, with reflected most profoundly in somatomotor network. Late-season appear affect all without association magnitude HAEs experienced. These observations demonstrate that participation...