A5069592000- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- COVID-19 and Mental Health
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Decision-Making and Behavioral Economics
- Neural and Behavioral Psychology Studies
- Behavioral Health and Interventions
- Color perception and design
- Mitochondrial Function and Pathology
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- High Altitude and Hypoxia
- Suicide and Self-Harm Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Effects of Exercise
- MicroRNA in disease regulation
- Exercise and Physiological Responses
- Wnt/β-catenin signaling in development and cancer
- Microfluidic and Capillary Electrophoresis Applications
- Teaching and Learning Programming
- Behavioral and Psychological Studies
University of Cincinnati
2022-2024
Purdue University West Lafayette
2019-2023
Northwestern University
2020-2022
Abstract Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions. In animal experiments, mammary tumor were inoculated into fat pad tibia. The role Lrp5-mediated was examined by overexpressing silencing Lrp5 osteocytes establishing conditional knockout mouse model. results revealed that administration or their conditioned medium (CM) inhibited progression osteolysis....
Although the mental health impacts of COVID-19 on general population have been well studied, studies long-term infected individuals are relatively new. To date, depression, anxiety, and neurological symptoms associated with post-COVID-19 syndrome (PCS) observed in months following recovery. Suicidal thoughts behavior (STB) also preliminarily proposed as sequelae COVID-19.We asked 3 questions. First, do participants reporting a history diagnosis or close relative having severe score higher...
Despite COVID-19 vaccine mandates, many chose to forgo vaccination, raising questions about the psychology underlying how judgment affects these choices. Research shows that reward and aversion judgments are important for vaccination choice; however, no studies have integrated such cognitive science with machine learning predict uptake.
Abstract American football has become the focus of numerous studies highlighting a growing concern that cumulative exposure to repetitive, sports-related head acceleration events (HAEs) may have negative consequences for brain health, even in absence diagnosed concussion. In this longitudinal study, functional connectivity was analyzed cohort high school athletes over single play season and compared against participants non-collision sports. Football underwent four resting-state magnetic...
Abstract The prediction of suicidal thought and behavior has met with mixed results. This study 3,476 de-identified participants (4,019 before data exclusion) quantified the four (STB) variables using a short reward/aversion judgment task limited set demographic mental health surveys. focus was to produce simple, quick objective framework for assessing STB that might be automatable, without use big data. A balanced random forest classifier performed better than Gaussian mixture model...
Reports estimate between 1.6-3.8 million sports-related concussions occur annually, with 30% occurring in youth male American football athletes. Many studies report neurophysiological changes these athletes, but the exact reasons for remain elusive. Investigation of injury mechanics highlights a need to address how player position might impact changes. Here, 55 high school athletes (20 linemen; 35 non-linemen) underwent magnetic resonance spectroscopy four times over course season—once prior...
Background Rates of depression and addiction have risen drastically over the past decade, but lack integrative techniques remains a barrier to accurate diagnoses these mental illnesses. Changes in reward/aversion behavior corresponding brain structures been identified those with major depressive disorder (MDD) cocaine-dependence polysubstance abuse (CD). Assessment statistical interactions between computational structure may quantitatively segregate MDD CD. Methods Here, 111 participants [40...
Abstract Anxiety, a condition characterized by intense fear and persistent worry, affects millions each year and, when severe, is distressing functionally impairing. Numerous machine learning frameworks have been developed tested to predict features of anxiety traits. This study extended these approaches using small set interpretable judgment variables ( n = 15) contextual (demographics, perceived loneliness, COVID-19 history) (1) understand the relationships between (2) develop framework...
Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male athletes before athletic season (Pre) after last game (Post). Samples underwent nontargeted metabolomic profiling 1131 metabolites were included for univariate, pathway enrichment, multivariate...
Abstract Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in novel demonstration of “imaging omics.” Data collected National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships 1) elevated levels miR-30d miR-92a to putamen rCBF, 2) rCBF compromised Balance scores, 3) scores microRNA (miRNA) levels. acted as...
Female athletes are under-studied in the field of concussion research, despite evidence higher injury prevalence and longer recovery time. Hormonal fluctuations caused by natural menstrual cycle (MC) or hormonal contraceptive (HC) use impact both post-injury symptoms neuroimaging findings, but relationships among hormone, symptoms, brain-based measures have not been jointly considered studies. In this preliminary study, we compared cerebral blood flow (CBF) measured with arterial spin...
The COVID-19 disease results from infection by the SARS-CoV-2 virus to produce a range of mild severe physical, neurological, and mental health symptoms. pandemic has indirectly caused significant emotional distress, triggering emergence symptoms in individuals who were not previously affected or exacerbating those with existing conditions. Emotional distress certain conditions can lead violent ideation disruptive behavior, including aggression, threatening acts, deliberate harm toward other...
Vasoactive stress tests (i.e. hypercapnia, elevated partial pressure of arterial CO2 [PaCO2 ]) are commonly used in functional MRI (fMRI), to induce cerebral blood flow changes and expose hidden perfusion deficits the brain. Compared with fMRI, near-infrared spectroscopy (NIRS) is an alternative low-cost, real-time, non-invasive tool, which can be applied out-of-hospital settings. To develop optimize vasoactive for NIRS, several hypercapnia-induced tasks were tested using...
Operant keypress tasks, where each action has a consequence, have been analogized to the construct of "wanting" and produce lawful relationships in humans that quantify preferences for approach avoidance behavior. It is unknown if rating tasks without an operant framework, which can be "liking", show similar relationships. We studied three independent cohorts participants (N = 501, 506, 4,019 participants) collected by two distinct organizations, using same 7-point Likert scale rate negative...
Background The COVID-19 pandemic has heightened mental health concerns, but the temporal relationship between conditions and SARS-CoV-2 infection not yet been investigated. Specifically, psychological issues, violent behaviors, substance use were reported more during than before pandemic. However, it is unknown whether a prepandemic history of these increases an individual’s susceptibility to SARS-CoV-2. Objective This study aimed better understand risks underlying COVID-19, as important...
Contact sports affect measures at multiple scales such as transcriptomics, metabolomics, brain function, and behavior, but studies have not yet studied the statistical structure of how they are integrated. This preliminary study, examining collegiate American football players, integrated across-season changes (Δ) from transcriptomic metabolomic variables (neuroinflammatory miRNAs metabolites), neuroimaging (resting-state fMRI network fingerprint similarity), virtual reality (VR)-based motor...
Research suggests contact sports affect neurological health. This study used permutation-based mediation statistics to integrate measures of metabolomics, neuroinflammatory miRNAs, and virtual reality (VR)-based motor control investigate multi-scale relationships across a season collegiate American football. Fourteen significant mediations (six pre-season, eight across-season) were observed where metabolites always mediated the statistical relationship between miRNAs VR-based ( pSobelperm≤...
Abstract Operant keypress tasks in a reinforcement-reward framework where behavior is shaped by its consequence, show lawful relationships human preference (i.e., approach/avoidance) and have been analogized to “wanting”. However, they take 20–40 min as opposed short non-operant rating tasks, which can be 3 unsupervised, thus more readily applied internet research. It unknown if each action does not analogous “liking”, similar relationships. We studied non-operant, picture-rating data from...
Magnetic resonance imaging (MRI) plays a critical role in visualizing the structure and functions of human body. In order to accelerate time improve image quality, radio-frequency (RF) coil receive arrays are commonly employed acquire magnetic (MR) signal. Similarly, multiple transmit coils have been shown refine RF excitation. this work, we investigate optimization total accuracy when considering both arrays; term strategy multiple-input multiple-output (MIMO) MRI. Our pulse design method...
Implantable, bioresorbable drug delivery systems offer an alternative to current administration techniques; allowing for patient-tailored dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows the acceleration of design release systems, and prediction physical anomalies that are not intuitive may otherwise elude discovery. This study investigates short-term as a function water-mediated polymer phase inversion into solid depot within hours days, well...
Human brains develop across the life span and largely vary in morphology. Adolescent collision-sport athletes undergo repetitive head impacts over years of practices competitions, therefore may exhibit a neuroanatomical trajectory different from healthy adolescents general. However, an unbiased brain atlas targeting these individuals does not exist. Although standardized atlases facilitate spatial normalization voxel-wise analysis at group level, when underlying neuroanatomy represent study...