A5040562982- Advanced MRI Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Advanced NMR Techniques and Applications
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Trace Elements in Health
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- NMR spectroscopy and applications
- Genetic Neurodegenerative Diseases
- Electrochemical Analysis and Applications
- Tryptophan and brain disorders
- Diet and metabolism studies
- Neuroscience and Neural Engineering
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Migraine and Headache Studies
- Mercury impact and mitigation studies
- Electron Spin Resonance Studies
- Nuclear Physics and Applications
- Lanthanide and Transition Metal Complexes
Indiana University – Purdue University Indianapolis
2015-2025
Indiana University School of Medicine
2015-2025
Purdue University West Lafayette
2016-2025
Baton Rouge Clinic
2024
Takeda (United States)
2024
University of California, San Francisco
2024
University of Oregon
2021
Indiana University
2016-2019
University School
2018
Indiana University Bloomington
2008-2016
Schizophrenia is a major psychiatric disease, which affects the centre of personality, with severe problems perception, cognition as well affective and social behaviour. In cerebrospinal fluid drug-free schizophrenic patients, significant decrease in level total glutathione (GSH) by 27% (P<0.05) was observed compared to controls, keeping reported reduced its metabolite gamma-glutamylglutamine. With new non-invasive proton magnetic resonance spectroscopy methodology, GSH medial prefrontal...
<h3>Context</h3> Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia. <h3>Objectives</h3> To contextualize metabolic, functional, clinical parameters thus reveal cellular mechanisms related <h3>Design</h3> The pgACC was investigated using combined magnetic resonance imaging spectroscopic approach. Negative blood oxygenation...
Exposure to excessive levels of manganese (Mn) is known induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection Mn neurotoxicity desirable.Our goal was determine whether in vivo brain γ-aminobutyric acid (GABA), N-acetylaspartate (NAA), other metabolites male smelters were altered as consequence exposure.We used T1-weighted magnetic resonance imaging (MRI) visualize deposition the brain. Magnetic spectroscopy (MRS)...
Although manganese (Mn) is a trace metal essential for humans, chronic exposure to Mn can cause accumulation of this ion in the brain leading an increased risk neurological and neurobehavioral health effects. This concern welders exposed through welding fumes. While occupational settings has mostly been reported basal ganglia, several imaging studies also revealed elevated other areas. Since functions as magnetic resonance (MRI) T1 contrast agent, we developed whole-brain MRI approach map...
Abstract Phosphorus-31 magnetic resonance spectroscopic imaging ( 31 P-MRSI) provides valuable non-invasivein vivoinformation on tissue metabolism but is burdened by poor sensitivity and prolonged scan duration. Ultra-short echo time (UTE) acquisitions minimize signal loss when probing signals with relatively short spin-spin relaxation (T 2 ), while also preventing first-order dephasing. Here, a three-dimensional (3D) UTE sequence rosette k-space trajectory (PETALUTE) applied to P-MRSI at...
Abstract Sensitivity encoding (SENSE) offers a new, highly effective approach to reducing the acquisition time in spectroscopic imaging (SI). In contrast conventional fast SI techniques, which accelerate k ‐space sampling, this method permits number of phase steps each dimension SI. Using coil array for data acquisition, missing information is recovered exploiting knowledge distinct spatial sensitivities individual elements. work, SENSE applied 2D imaging. Fourfold reduction scan achieved at...
With growing evidence of long-term neurological damage in individuals enduring repetitive head trauma, it is critical to detect lower-level accumulation for the early diagnosis injury at-risk populations. Proton magnetic resonance spectroscopic scans dorsolateral prefrontal cortex and primary motor were collected from high school American (gridiron) football athletes, prior during their competition seasons. Although no concussions diagnosed, significant metabolic deviations baseline...
Magnetic resonance spectroscopy and helmet telemetry were used to monitor the neural metabolic response repetitive head collisions in 25 high school American football athletes. Specific hit characteristics determined highly predictive of alterations, suggesting that sub-concussive blows can produce biochemical changes potentially lead neurological problems.
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the human brain. Several algorithms available modelling these data, deriving metabolite concentration estimates through peak fitting or a linear combination of basis spectra. The present study compares seven such algorithms, using data obtained large multisite study. GABA‐edited (GABA+, TE = 68 ms MEGA‐PRESS) from 222 subjects at 20 sites were processed via standardised pipeline, before with FSL‐MRS, Gannet,...
Lactose maldigesters report an increase in abdominal pain due to the consumption of milk containing a mixture A1 and A2 β-casein as compared only β-casein. Gastric transit affects gastrointestinal symptoms rapid has been associated with pain. We conducted double-blinded, randomized, crossover trial 10 lactose maldigesters. Subjects consumed each two types milk: conventional 75% 25% 100% Magnetic resonance images were acquired, was rated recorded at 0, 10, 30, 60 120 min after consumption....
Migraine pathophysiology possibly involves deficient mitochondrial energy reserve and diminished cortical habituation. Using functional magnetic resonance spectroscopic imaging (fMRSI), we studied lactate changes during prolonged visual stimulation to search for different pathophysiological mechanisms in clinically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV) 10 patients were investigated interictally: five aura (MA) symptoms at least one the following:...