A5042997584- Advanced MRI Techniques and Applications
- Image and Video Stabilization
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Sulfur Compounds in Biology
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Advanced Vision and Imaging
- Advanced Optical Imaging Technologies
- Metabolomics and Mass Spectrometry Studies
- Head and Neck Cancer Studies
- Lanthanide and Transition Metal Complexes
- Dementia and Cognitive Impairment Research
- Tumors and Oncological Cases
- Neonatal and fetal brain pathology
- Viral Infections and Vectors
- Dental Health and Care Utilization
- Bone Tumor Diagnosis and Treatments
- Advanced NMR Techniques and Applications
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Mosquito-borne diseases and control
- Oral and Craniofacial Lesions
- Face recognition and analysis
- Advanced Neuroimaging Techniques and Applications
Nirma University
2016-2024
Banasthali University
2024
National Brain Research Centre
2017-2023
Maharana Pratap University of Agriculture and Technology
2023
Imperial College London
2021-2022
Nethradhama Superspeciality Eye Hospital
2022
All India Institute of Medical Sciences
2015-2018
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2017
Indian Institute of Management Lucknow
2017
Indian Institute of Information Technology Design and Manufacturing Jabalpur
2013-2016
BackgroundAlthough therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy low-income middle-income countries is unclear. We aimed to examine whether alongside optimal supportive intensive care moderate severe south Asia.MethodsWe did a multicountry open-label, randomised controlled trial seven tertiary units India, Sri Lanka, Bangladesh. enrolled infants born at 36 weeks of gestation with need for continued...
No drug, used as adjuvant to spinal bupivacaine, has yet been identified that specifically inhibits nociception without its associated side-effects.This prospective randomized double-blind study was conducted evaluate the onset and duration of sensory motor block well perioperative analgesia adverse effects dexmedetomidine magnesium sulfate given intrathecally with 0.5% hyperbaric bupivacaine for anesthesia.A total 90 patients classified American Society Anesthesiologists status I II...
Abstract Oxidative stress (OS) plays an important role in Alzheimer's disease (AD) and glutathione (GSH) mitigates this effect by maintaining redox‐imbalance free‐radical neutralization. Quantified brain GSH concentration provides distinct information about OS among age‐matched normal control (NC), mild cognitive impairment (MCI) AD patients. We report alterations of vivo conformers, along with the choline, creatine, N ‐acetylaspartate levels cingulate cortex (CC) containing anterior (ACC)...
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the human brain. Several algorithms available modelling these data, deriving metabolite concentration estimates through peak fitting or a linear combination of basis spectra. The present study compares seven such algorithms, using data obtained large multisite study. GABA‐edited (GABA+, TE = 68 ms MEGA‐PRESS) from 222 subjects at 20 sites were processed via standardised pipeline, before with FSL‐MRS, Gannet,...
Abstract Oxidative stress has been implicated in Alzheimer’s disease, and it is potentially driven by the depletion of primary antioxidant, glutathione, as well elevation pro-oxidant, iron. Present study evaluates glutathione level magnetic resonance spectroscopy, iron deposition quantitative susceptibility mapping left hippocampus, neuropsychological scores healthy old participants (N = 25), mild cognitive impairment 16) disease patients 31). Glutathione was found to be significantly...
This study aimed to determine the prevalence of certain oral characteristics usually associated with Down syndrome and health status these patients.The cross-sectional was conducted among patients attending a special education program at Faculty Dentistry, Jamia Millia Islamia, Delhi, India. The design consisted closed-ended questions on demographic (age, sex, income parents), dietary habits, hygiene habits. Clinical examination included assessment according Simplified Oral Hygiene Index...
Parkinson's disease (PD) is characterized by extrapyramidal motor disturbances and nonmotor cognitive impairments which impact activities of daily living. Although the etiology PD still obscure, autopsy reports suggest that oxidative stress (OS) one important factors in pathophysiology PD. In current study, we have investigated OS measuring antioxidant glutathione (GSH) levels from substantia nigra (SN), left hippocampus (LH) neurotransmitter γ-amino butyric acid (GABA) SN region....
Polymorphisms in the genes that code for metabolic enzymes involved either activation (Phase I) or detoxication II) of chemical carcinogens tobacco, may alter expression function carcinogenic compounds and hence risk oral cancer. The present study investigates whether polymorphisms at CYP1A1 GSTM1 gene loci act as factors precancerous lesions cancer.For study, histopathologically confirmed cases 90 lesions, 150 squamous cell carcinoma (SCC) control subjects were selected. Polymerase chain...
Molecular dynamics simulation and in vitro nuclear magnetic resonance (NMR) studies on glutathione (GSH) indicated existence of closed extended conformations. The present work a multi-center research setting reports in-depth analysis GSH conformers vivo using common spectroscopy (MRS) protocol signal processing scheme. MEGA-PRESS pulse sequence was applied healthy subjects 3T Philips MRI scanner (India) GE (Norway) the same experimental parameters (echo time, repetition selective 180°...
In our routine review of Oral Submucous Fibrosis (OSMF) biopsies, we observed decreased adipose tissue even though most are from buccal mucosa. Pathogenesis OSMF has demonstrated the role Transforming Growth Factor β (TGF β), in causing fibrosis. This study aims to correlate TGF with loss OSMF.From archives, 84 cases (24 early and 60 advanced OSMF) were screened for tissue. Immunoexpression these investigated.Adipose was seen 67% 13% cases. Early showed more intense staining epithelium,...
Oxidative stress plays a major role in Alzheimer's disease (AD) pathogenesis, and thus, antioxidant glutathione (GSH) has been actively investigated mitigating the oxidative load. Significant hippocampal GSH depletion correlated with cognitive impairment AD. Furthermore, postmortem studies indicated alterations cellular-energy metabolism pH change toward alkalinity AD.Concurrent analysis of interplay vivo on same individual is quite unclear hence requires investigation to understand...
Alzheimer's disease (AD) is a devastating neurodegenerative brain disorder affecting cognitive ability of millions people worldwide. Progressive and relentless efforts are in war footing for therapeutic development by understanding involving non-invasive imaging modalities the causal molecular process AD, modalities. Currently available structural, functional MR spectroscopic studies being used to aid effective AD diagnosis. The 'Big Data' multi-modal informatics can be unified analyze,...
Early detection of oral cancer is paramount importance in determining the prognosis cancer. Literature suggests that several diagnostic modalities have been proposed to aid a clinician early without much conclusive evidence.The present study aims compare toluidine blue and chemiluminescence screening methods carcinoma North Indian population also evaluate these with histopathological diagnosis.In this prospective study, 42 patients clinically visible premalignant lesions were included....
Silver stainable nucleolar organizer regions (AgNORs) have received a great deal of attention recently as their frequency within the nuclei is significantly higher in malignant cells than normal, reactive or benign neoplastic cells. The objective this study was to carry out quantitative assessment large and small AgNORs oral normal mucosa, precancerous lesions infiltrating squamous cell carcinomas.The comprised 110 formalin-fixed, paraffin-embedded mucosal biopsies consisting 30 dysplasia,...
Cancer patient's inherited genotype may influence his or her survival, but evidence for the role of these genetic differences in oral cancer survival has not yet been explored.The authors evaluated polymorphisms GSTM1 and CYP1A1 genes associations with overall 100 squamous cell carcinoma (OSCC) treated patients controls who were followed up within 2 years date completion their treatment. Overall was Kaplan-Meier functions Cox proportional hazards models.After adjustment stage histology,...
Recognition of fruits automatically using machine vision is considered as challenging task exist in various colors, sizes, shapes and textures. Additionally, when images are acquired them, variation introduced due to imaging conditions also. In this paper we have recognized nine different classes fruits. Fruit image dataset obtained from web well certain by mobile phone camera. These pre-processed subtract the background extract blob representing fruit. For capturing their visual...