Susan R. Criswell
A5069345448- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Ginkgo biloba and Cashew Applications
- Mercury impact and mitigation studies
- Pesticide Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Aluminum toxicity and tolerance in plants and animals
- Obstructive Sleep Apnea Research
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- PARP inhibition in cancer therapy
- Quality and Safety in Healthcare
- Radiation Dose and Imaging
- Advanced Fluorescence Microscopy Techniques
- Traumatic Brain Injury Research
- Sleep and related disorders
- Biomedical Text Mining and Ontologies
Barrow Neurological Institute
2023-2025
Washington University in St. Louis
2014-2024
Banner Sun Health Research Institute
2024
University of Arizona
2024
Centre National de la Recherche Scientifique
2024
Banner - University Medical Center Phoenix
2024
Institut Pascal
2024
Université Clermont Auvergne
2024
Montreal Neurological Institute and Hospital
2024
McGill University Health Centre
2024
<i>Background:</i> Parkinson disease is a common neurodegenerative disease. The racial, sex, age, and geographic distributions of in the US are unknown. <i>Methods:</i> We performed serial cross-sectional study Medicare beneficiaries aged 65 older from years 1995, 2000–2005. Using over 450,000 cases per year, we calculated prevalence annual incidence by race, county. Spatial analysis investigated distribution <i>Results:</i> Age-standardized (per 100,000)...
Classical accounts of the pathophysiology Parkinson's disease have emphasized degeneration dopaminergic nigrostriatal neurons with consequent dysfunction cortico–striatal–thalamic loops. In contrast, post-mortem studies indicate that pathological changes in (Lewy neurites and Lewy bodies) first appear primarily lower brainstem subsequent progression to more rostral parts neuraxis. The histological perspectives are not incompatible, but they do emphasize different anatomical structures. To...
<h3>Importance</h3> Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives may therefore lead to stable systemic exposure while preserving key pharmacological activity. <h3>Objective</h3> To evaluate efficacy safety of deutetrabenazine treatment control chorea associated with Huntington disease. <h3>Design, Setting, Participants</h3> Ninety ambulatory adults diagnosed manifest disease baseline total maximal...
Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, clinical data.To determine whether sustained urate-elevating treatment the urate precursor inosine slows early PD progression.Randomized, double-blind, placebo-controlled, phase 3 trial of oral in PD. A total 587 individuals consented, 298 not yet requiring...
To determine whether the parkinsonian phenotype prevalent in welders is progressive, and progression related to degree of exposure manganese (Mn)-containing welding fume.This was a trade union-based longitudinal cohort study 886 American welding-exposed workers with 1,492 examinations by movement disorders specialist, including 398 606 follow-up up 9.9 years after baseline. We performed linear mixed model regression cumulative Mn as independent variable annual change Unified Parkinson...
Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment Parkinson's disease (PD), is administered as 24-hour/day continuous subcutaneous infusion (CSCI) with single site. The efficacy and safety foslevodopa/foscarbidopa versus oral immediate-release LD/CD was previously demonstrated in patients PD 12-week, randomized, double-blind, phase 3 trial (NCT04380142). We report results separate 52-week, open-label, registrational (NCT03781167) that...
Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created multisite participant, primarily clinic-based cohort better understand characteristics diagnosis, and in future work, identify predictors...
ASPEN-1 was a phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, duration of response, and safety 2 doses DaxibotulinumtoxinA for Injection (DAXI), novel botulinum toxin type A formulation in participants with cervical dystonia (CD).
<h3>Objectives</h3> Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in globus pallidus associated increased T1-weighted MRI signal. T1 signal intensity extra-pallidal basal ganglia (caudate and putamen) has not been studied occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage may provide quantification neurotoxicity welding manganese exposure. This study investigated as marker diffusion...
<h3>Background:</h3> Welding exposes workers to manganese (Mn) fumes, but it is unclear if this exposure damages dopaminergic neurons in the basal ganglia and predisposes individuals develop parkinsonism. PET imaging with 6-[<sup>18</sup>F]fluoro-l-dopa (FDOPA) a noninvasive measure of nigrostriatal neuron integrity. The purpose study determine whether welding associated damage asymptomatic workers. <h3>Methods:</h3> We imaged 20 welders exposed Mn subjects idiopathic Parkinson disease...
REM sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment. The International RBD Study Group developed the Symptom Severity Scale (RBDSSS) to assess symptom severity for clinical or research use. We assessed psychometric and clinimetric properties of RBDSSS in participants enrolled North American Prodromal Synucleinopathy (NAPS) Consortium RBD. NAPS participants, who have polysomnogram-confirmed RBD, their bedpartners completed (participant bedpartner versions)....
Abstract Study Objectives Rapid eye movement sleep behavior disorder (RBD) is strongly associated with phenoconversion to an overt synucleinopathy, e.g. Parkinson’s disease (PD), Lewy body dementia, and related disorders. Comorbid traumatic brain injury (TBI) posttraumatic stress (PTSD)—henceforth “neurotrauma” (NT)—increase the odds of RBD by ~2.5-fold are increased rate service-connected PD in Veterans. Thus, NT both independently PD; however, it unclear how influences neurological...
Although levodopa is considered the most effective pharmacotherapy for motor symptoms of Parkinson's disease (PD), chronic use associated with complications, including fluctuating response and unpredictable, involuntary movements called dyskinesia. ADS-5102 (amantadine) extended-release (ER) capsules (GOCOVRITM) a recent US FDA-approved treatment dyskinesia in PD patients. high-dose, ER formulation amantadine, administered orally once daily at bedtime, that achieves high plasma drug...
Abstract Background Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives Assess correlations between sleep and efficacy from interim data phase 3 trial foslevodopa/foscarbidopa (NCT03781167). Methods Pearson (Parkinson's Disease Sleep Scale‐2 [PDSS‐2]) quality life (QoL; Parkinson's Questionnaire‐39), motor experiences daily living (m‐EDL; Movement Disorder Society‐Unified Scale Part II), “Off”/“On” times were calculated for baseline week 26...
Objective Long-term, high-level exposure to manganese (Mn) is associated with impaired central nervous system (CNS) function. We quantitatively explored relations between low-level Mn and selected neurological outcomes in a longitudinal inception cohort of asymptomatic welder trainees. Methods Welders no previous occupational were observed approximately every three months over the course five-quarter traineeship. Fifty-six welders assessed for motor function using Unified Parkinson Disease...
Abstract Background The clinical diagnosis of Parkinson's disease (PD) requires the presence parkinsonism and supportive criteria that include a clear dramatic beneficial response to dopaminergic therapy. Our aim was test diagnostic criterion by evaluating its association with pathologically confirmed diagnoses in large population parkinsonian patients. Methods We reviewed data maintained an electronic medical record from all patients autopsy who had been seen Movement Disorders Center at...
Objective: T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure manganese (Mn) exposure, and may also represent biomarker for clinical neurotoxicity. Methods: We acquired MRI scans in 27 Mn-exposed welders, 12 other workers, 29 nonexposed participants. intensity indices were calculated four regions. Cumulative Mn exposure was estimated from work history data. Participants examined using Unified Parkinson's Disease Rating Scale motor...
Deutetrabenazine is approved in the USA, China, Australia, Israel, Brazil, and South Korea for treatment of chorea associated with Huntington disease. We aimed to evaluate long-term safety tolerability deutetrabenazine This open-label, single-arm, multi-center study included patients who completed a double-blind (Rollover) converted overnight from stable tetrabenazine dose (Switch). Exposure-adjusted incidence rates (adverse events per person-year) were calculated. Efficacy was analyzed...