A5045563003- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Advanced MRI Techniques and Applications
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Neurological and metabolic disorders
- Neurogenesis and neuroplasticity mechanisms
- Restless Legs Syndrome Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neurological diseases and metabolism
- Ion channel regulation and function
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
The University of Texas Health Science Center at Houston
2016-2025
Institute for Neurodegenerative Disorders
2023
Neurology, Inc
2020
The University of Texas at Austin
2004-2015
Texas Medical Center
2008
Memorial Hermann
2006
The University of Texas Medical Branch at Galveston
1988-1999
The University of Texas Southwestern Medical Center
1987
UConn Health
1982
An assay for detecting phosphorylated α-synuclein in CSF may help to diagnose Parkinson’s disease and determine severity.
Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, clinical data.To determine whether sustained urate-elevating treatment the urate precursor inosine slows early PD progression.Randomized, double-blind, placebo-controlled, phase 3 trial of oral in PD. A total 587 individuals consented, 298 not yet requiring...
Background and purpose The intestinal microbiome plays a primary role in the pathogenesis of neurodegenerative disorders may provide an opportunity for disease modification. We performed pilot clinical study looking at safety fecal microbiota transplantation (FMT), its effect on microbiome, improvement symptoms Parkinson's disease. Methods This was randomized, double-blind placebo-controlled study, wherein orally administered lyophilized FMT product or matching placebo given to 12 subjects...
Abstract The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is powerful early predictor eventual phenoconversion, therefore represents critical opportunity to intervene neuroprotective therapy. To inform the design randomized trials, it essential study natural progression...
Rapid eye movement sleep behavior disorder (RBD) is a condition closely associated with Parkinson disease (PD). RBD disturbance that frequently manifests early in the development of PD, likely reflecting disruption normal functioning anatomical areas affected by neurodegenerative processes. Although specific neuropathological aspects shared and PD have yet to be fully documented, further characterization critical discovering reliable biomarkers predict onset. In current study, we tested...
The integrity of frontal systems responsible for voluntary control and their interaction with subcortical regions involved in reflexive responses were studied patients Parkinson's disease (PD). Previous studies have shown that PD impaired executive function, including deficits attention, motor planning decision making.Executive function was measured through eye movements: (stimulus driven) prosaccades (internally guided) antisaccades. Patients advanced idiopathic PD, off on optimal levodopa...
α-synuclein is thought to play a key role in Parkinson's disease (PD) because it the major protein Lewy bodies, and its gene mutations, duplication, triplication are associated with early-onset PD. There conflicting reports as whether serum plasma concentrations of anti-α-synuclein antibodies differ between PD control subjects. The objectives this study were compare levels individuals typical (n = 14), atypical Parkinson syndromes 11), idiopathic rapid eye movement sleep behavior disorder...
ABSTRACT Background Direct targeting of the dentato‐rubro‐thalamic tract is efficacious in DBS for tremor suppression. Objectives We sought to compare outcomes and optimal stimulation parameters control using technique directly those who underwent indirect ventral intermediate nucleus thalamus. Methods Twenty consecutive essential patients obtained preoperative diffusion MRIs, where was individually drawn used target thalamus during surgery. These were compared an earlier cohort 20 surgery...
ABSTRACT Background Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone marrow–derived mesenchymal stem cells can be used as an immunomodulatory therapy. Objective The objective of this study was to prove the safety tolerability intravenous patients. Methods This 12‐month single‐center open‐label dose‐escalation phase 1 20 subjects with mild/moderate assigned single infusion 4 doses: 1, 3, 6, or 10 × 6 cells/kg, evaluated 12, 24, 52 weeks postinfusion. Primary outcome...
OBJECTIVE Patients with Parkinson disease (PD) who undergo subthalamic nucleus (STN) deep brain stimulation (DBS) often develop a deterioration in speech performance, but there is no clear consensus on the specific effects seen or mechanism involved and little description of impact DBS conversational speech. Furthermore, has been fiber tract connectivity analysis to identify structures potentially modulated by cause such deficits. The main objective this study was quantify spontaneous...
The Trail Making Test (TMT) is one of the most frequently administered neuropsychological instruments, having been used in evaluation cognitive dysfunction for over 50 years. Despite measure's extensive clinical use and proliferation research, no comprehensive review adult TMT normative literature available. This report examines available reports provides a summary sample characteristics. Significant variability between studies precludes metanorms. Clinically, these findings indicate that...
<h3>Objective:</h3> To examine the cognitive sequelae of unilateral posteroventral pallidotomy. <h3>Design:</h3> Single-group pretest and posttest methodologic assessment with baseline evaluation performed 1 to 2 days prior surgery follow-up conducted 3 months after <h3>Setting:</h3> Movement disorder clinic at a university medical center. <h3>Patients:</h3> Fourteen patients (age range, 43-82 years) Parkinson disease (average duration, 7.4 years). <h3>Intervention:</h3> Unilateral...
Motor classifications of Parkinson's Disease (PD) have been widely used. This paper aims to update a subtype classification using the MDS-UPDRS-III and determine if cerebrospinal neurotransmitter profiles (HVA 5-HIAA) differ between these subtypes in cohort from Progression Marker Initiative (PPMI).UPDRS MDS-UPDRS scores were collected for 20 PD patients. Akinetic-rigid (AR), Tremor-dominant (TD), Mixed (MX) calculated formula derived UPDRS, new ratio was developed subtyping patients with...
Forty central amygdala neurons labelled with 2% Neurobiotin were categorized according to their distinctive bioelectrical membrane properties and classified physiologically by hyperpolarized resting potential (−74 mV), short duration medium afterhyperpolarization (239.2 ms), non-accommodating response as Type A (63%; N = 25/40), or B (37%; 15/40) depolarized (-66 long slow-afterhyperpolarization (1.8 s), accommodation response. Visualized within subnuclei of the amygdala,...