A5019415952- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Mental Health and Psychiatry
- Diversity and Career in Medicine
- Healthcare professionals’ stress and burnout
- Functional Brain Connectivity Studies
- Innovations in Medical Education
- Neurology and Historical Studies
- Transcranial Magnetic Stimulation Studies
- Body Image and Dysmorphia Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Long-Term Effects of COVID-19
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
- Occupational Therapy Practice and Research
- Neurological diseases and metabolism
- Cerebral Palsy and Movement Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mindfulness and Compassion Interventions
- Pain Management and Treatment
Saratoga Hospital
2021-2023
Northwestern University
2019-2022
University of Louisville
2014-2022
The Huntington Library, Art Museum, and Botanical Gardens
2022
Neurosciences Institute
2020
University of New Mexico
2020
University of Washington Medical Center
2020
Emory University
2020
Abbott (United States)
2020
Texas Tech University Health Sciences Center
2019
<h3>Importance</h3> Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives may therefore lead to stable systemic exposure while preserving key pharmacological activity. <h3>Objective</h3> To evaluate efficacy safety of deutetrabenazine treatment control chorea associated with Huntington disease. <h3>Design, Setting, Participants</h3> Ninety ambulatory adults diagnosed manifest disease baseline total maximal...
To investigate the neural mechanisms underlying impaired self-agency in patients with functional movement disorders using resting-state MRI (fMRI).We obtained fMRI on 35 clinically definite and age- sex-matched healthy controls. Between-group differences connectivity from right temporo-parietal junction (TPJ), a region previously demonstrated to play critical role by comparing internal predictions of actual external events, were assessed t tests. All participants screened for psychiatric...
Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, clinical data.To determine whether sustained urate-elevating treatment the urate precursor inosine slows early PD progression.Randomized, double-blind, placebo-controlled, phase 3 trial of oral in PD. A total 587 individuals consented, 298 not yet requiring...
<h3>Objective</h3> To examine age and sex differences in burnout, career satisfaction, well-being US neurologists. <h3>Methods</h3> Quantitative qualitative analyses of men9s (n = 1,091) women9s 580) responses to a 2016 survey <h3>Results</h3> Emotional exhaustion neurologists initially increased with age, then started decrease as got older. Depersonalization decreased Fatigue overall quality life worsened improve More women (64.6%) than men (57.8%) met burnout criteria on univariate...
To ascertain demographic and clinical features of Parkinson disease (PD) associated with functional neurological features.A standardised form was used to extract data from electronic records 53 PD patients disorders (PD-FND) across eight movement centres in the USA, Canada Europe. These subjects were matched for age, gender duration without (PD-only). Logistic regression analysis compare both groups after adjusting clustering effect.Functional symptoms preceded or co-occurred onset 34%...
Abstract SIGNAL is a multicenter, randomized, double-blind, placebo-controlled phase 2 study (no. NCT02481674) established to evaluate pepinemab, semaphorin 4D (SEMA4D)-blocking antibody, for treatment of Huntington’s disease (HD). The trial enrolled total 265 HD gene expansion carriers with either early manifest (EM, n = 179) or late prodromal (LP, 86) HD, randomized (1:1) receive 18 monthly infusions pepinemab ( 91 EM, 41 LP) placebo 88 45 LP). Pepinemab was generally well tolerated,...
To characterize neurologic manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized (NNP) patients.
ABSTRACT The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike movement, however, patients lack a sense of control for the movements, failure “self‐agency.” action‐effect binding paradigm has been used quantify self‐agency, because subjective contraction time between an action its effect only occurs if patient feels that they agent responsible action. We this paradigm, coupled with emotional stimuli,...
Functional movement disorders (FMDs) are conditions of abnormal motor control thought to be caused by psychological factors. These commonly seen in neurologic practice, and prognosis is often poor. No consensus treatment guidelines have been established; however, the role physical therapy addition psychotherapy has increasingly recognized. This study reports patient outcomes from a multidisciplinary FMD program using retraining (MoRe) strategies.To assess patients undergoing determine...
Background and purpose There is large variability in the diagnostic approach clinical management functional movement disorders (FMD). This study aimed to examine whether opinions practices related FMD have changed over past decade. Methods Adapted from a 2008 version, we repeated survey members of International Parkinson Movement Disorder Society (MDS). Results In all, 864/7689 responses (denominator includes non‐neurologists) were received 92 countries. Respondents more often male (55%),...
To explore alterations in gray matter volume patients with functional movement disorders.We obtained T1-weighted MRI on 48 clinically definite disorders, a subset of neurologic symptom disorder characterized by abnormal involuntary movements, and 55 age- sex-matched healthy controls. We compared between-group differences using voxel-based morphometry across the whole brain. All participants addition underwent thorough neuropsychological battery, including Hamilton Anxiety Depression Scales...
Professional burnout is a growing problem among physicians. Neurology has been found to be one of the specialties with highest prevalence for burnout. However, little known about gender-specific risk factors. The objectives this study were (1) determine sample women neurologists in United States and (2) identify predictive factors leading burnout.An online survey was distributed 798 U.S. through closed Facebook group Women Neurologists Group. Burnout assessed Mini-Z survey. Additional...
Abstract Functional neurological disorder (FND) encompasses a complex and heterogeneous group of neuropsychiatric syndromes commonly encountered in clinical practice. Patients with FND may present myriad symptoms frequently have comorbid medical, neurological, psychiatric disorders. Over the past decade, important advances been made understanding pathophysiology within biopsychosocial framework. Many challenges remain addressing stigma associated this diagnosis, refining diagnostic criteria,...
Deutetrabenazine is approved in the USA, China, Australia, Israel, Brazil, and South Korea for treatment of chorea associated with Huntington disease. We aimed to evaluate long-term safety tolerability deutetrabenazine This open-label, single-arm, multi-center study included patients who completed a double-blind (Rollover) converted overnight from stable tetrabenazine dose (Switch). Exposure-adjusted incidence rates (adverse events per person-year) were calculated. Efficacy was analyzed...