A5044183101- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Restless Legs Syndrome Research
- EEG and Brain-Computer Interfaces
- Sleep and Work-Related Fatigue
- Infant Health and Development
- Neurological disorders and treatments
- Impact of Light on Environment and Health
- Olfactory and Sensory Function Studies
- Photoreceptor and optogenetics research
- Obstructive Sleep Apnea Research
- Clinical Nutrition and Gastroenterology
- Infant Development and Preterm Care
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Transportation Planning and Optimization
- Neuroscience and Music Perception
- Biochemical effects in animals
- Dietary Effects on Health
- Retinal Development and Disorders
- Neonatal Respiratory Health Research
- Diet and metabolism studies
Charité - Universitätsmedizin Berlin
2013-2025
Freie Universität Berlin
1996-2025
St. Hedwig-Krankenhaus
2017-2025
Humboldt-Universität zu Berlin
2018-2025
Czech Academy of Sciences, Institute of Physiology
2016
PAREXEL International (United States)
1997
Inserm
1988-1991
University of Amsterdam
1990-1991
Hôpital Edouard Herriot
1991
Pitié-Salpêtrière Hospital
1988-1991
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, potentially intervene neuroprotective therapy. For future trials, it essential accurately estimate phenoconversion rate identify potential predictors phenoconversion. study assessed the disease risk neurodegeneration in large multicentre cohort...
BACKGROUND. The circadian clock is a fundamental and pervasive biological program that coordinates 24-hour rhythms in physiology, metabolism, behavior, it essential to health. Whereas therapy adapted time of day increasingly reported be highly successful, needs personalized, since internal different for each individual. In addition, not stable trait, but influenced by many factors, including genetic predisposition, age, sex, environmental light levels, season. An easy convenient diagnostic...
Abstract Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM) sleep behavior disorder (RBD). Although there are current American Academy of Sleep Medicine standards to diagnose RBD, several aspects need be addressed achieve harmonization across centers. Prodromal RBD a stage in which symptoms and signs evolving present, but do not yet meet established diagnostic criteria RBD. However, the boundary between prodromal definite still unclear. As common effort...
Abstract The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is powerful early predictor eventual phenoconversion, therefore represents critical opportunity to intervene neuroprotective therapy. To inform the design randomized trials, it essential study natural progression...
REM sleep behavior disorder (RBD) is clinically impressive by virtue of its vigorous behaviors usually accompanying vivid, striking dreams. The main feature the disorder, without muscle atonia, has been shown in a variety diseases; therefore, might possibly be underestimated. In an open-labeled trial, we treated six consecutive RBD patients over 6-week period with 3 mg melatonin given within 30 minutes before bedtime. There was dramatic clinical improvement five week which extended beyond...
Light during the day and darkness at night are crucial factors for proper entrainment of human circadian system to solar 24-h day. However, modern life work styles have led much more time spent indoors, often with lower daytime higher evening/nighttime light intensity from electrical lighting than outdoors. Whether this has long-term consequences health is being currently investigated. We tested if bright blue-enriched morning over several days could counteract detrimental effects inadequate...
Objective To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) predict the development Parkinson disease (PD) dementia Lewy bodies (DLB). Method s In this multicenter study International RBD group, 173 (mean age 70.5 ± 6.3 years, 70.5% males) polysomnography‐confirmed who eventually phenoconverted overt alpha‐synucleinopathy (RBD due synucleinopathy) were enrolled, underwent baseline...
Recent data suggest that melatonin may influence human physiology, including the sleep-wake cycle, in a time-dependent manner via body's internal clock. Rapid-eye-movement (REM) sleep expression is strongly circadian modulated, and impact of REM on primary brain functions, metabolic processes, immune system function has become increasingly clear over past decade. In our study, we evaluated effects exogenous disturbed humans. Fourteen consecutive outpatients (five women, nine men; mean age,...
Abstract INTRODUCTION Isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). This provides an opportunity to directly observe the evolution prodromal DLB identify which cognitive variables are strongest predictors evolving dementia. METHODS IRBD participants ( n = 754) from 10 centers International RBD Study Group underwent annual neuropsychological assessment. Competing risk...
This study describes the temporal distribution of slow-wave sleep (SWS) (defined as visually scored stages 3 + 4) across night for 16 infants aged between 20 weeks and 1 year, 17 children I 6 years, adults 36 years. In all three groups amounts SWS peaked during first nonrapid eye movement (NREM) episode. decreased children, but not infants. remained at a fairly constant level from second cycle onward, although many cycles were observed with zero SWS. The latter was evident very low tendency...
Nighttime melatonin suppression is the most commonly used method to indirectly quantify acute nonvisual light effects. Since principal zeitgeber in humans, there a need assess its strength during daytime as well. This especially important since humans evolved under natural daylight but now often spend their time indoors artificial light, resulting different quality and quantity of light. We tested whether pupillary response (PLR) could be marker for effects daytime. also recorded wake...
While short-term effects of artificial light on human sleep are increasingly being studied, reports long-term induced by season scarce. Assessments subjective length over the year suggest a substantially longer period during winter. Our retrospective study aimed to investigate seasonal variation in objective measures cohort patients living an urban environment. In 2019, three-night polysomnography was performed 292 with neuropsychiatric disturbances. Measures diagnostic second nights were...
REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described disorder. Its major impact the vigorous that often results in injuries to patient himself or people sleeping nearby. We treated 64-year-old male with clinically and polysomnographically confirmed diagnosis of RBD 3 mg melatonin, which led significant reduction motor activity during sleep, as measured by actigraphy (p < 0.0001 all analyzed movement parameters), full clinical recovery over 5-month...
Background Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a prodromal state of clinical α-synucleinopathies such as Parkinson’s disease and Lewy body dementia. The lead-time until conversion unknown. most reliable marker progression reduced striatal dopamine transporter (DAT) binding, but low availability imaging facilities limits general use. Our prospective observational study aimed to relate metrics REM without atonia (RWA)—a hallmark RBD—to DAT-binding ratios in...
ABSTRACT While artificial light in urban environments was previously thought to override seasonality humans, recent studies have challenged this assumption. We aimed explore the relationship between seasonally varying environmental factors and changes sleep architecture patients with neuropsychiatric disorders by comparing two consecutive years. In 770 patients, three‐night polysomnography performed at Clinic for Sleep & Chronomedicine (St. Hedwig Hospital, Berlin, Germany) 2018/2019....
ABSTRACT Timing and architecture of sleep are co‐driven by circadian rhythms modulated their major Zeitgeber light darkness. In a natural environment, one is exposed to 3.000 lx (cloudy winter sky) 100.000 (bright sunny sky). The aim the study was assess (1) habitual daytime exposure in urban (2) impact on objective night‐time sleep. Eleven healthy participants (mean age ± SD: 25.4 2.8 years; 6 male) wore eyeglass frames continuously recording illuminance levels vertically eye mounted...
ABSTRACT The Ikelos‐Rating Scale (Ikelos‐RS) is a new, expert‐interviewed and bedpartner‐reported severity marker assessing frequency expression of isolated REM sleep behaviour disorder (iRBD), precursor clinical α‐synucleinopathies. This study aimed to validate the Ikelos‐RS in 180 patients with three‐night PSG‐confirmed iRBD (68.4 ± 8.3 years; 139 m). Inter‐rater ( n = 45) test–retest reliabilities 25; 174 Ikelos‐RS) were evaluated. For construct validity, correlation analyses performed...
The etiology of Periodic Limb Movement Disorder (PLMD) as well the precise role melatonin in human physiology remains poorly understood. Inspired by a single case observation we performed presented study order to obtain first evidence for hypothesis that exogenous would decrease PLM's and thereby improves symptoms PLMD patients.N/A.N/A.Nine patients with time diagnosis without RLS were treated over six-week period 3 mg melatonin, taken between 10 11 p.m.N/A.Melatonin improved well-being 7 9...
To model sleep propensity (SP) as a continuous variable across 24 hours and to the post-noon nap zone, or post-lunch dip in performance, early evening trough SP.The present is variant of 2-process with 2 major modifications. (1) The circadian threshold process was replaced by drive R, derived from REM propensity, which shows strong modulation. (2) based on multiplicative interaction between input variables S R. parameters R were estimated experimental data. Thus, SP modeled drives, former...
Melatonin is recommended as a first-line treatment in isolated REM sleep behavior disorder (iRBD), although no large patient group has been reported. To assess effects, time course and confounding factors the of patients with iRBD using melatonin, 209 consecutive were included this single-center, observational cohort study. A total 171 had taken melatonin according to our chronobiotic protocol (2 mg, ≥6 months, always-at-the-same-clock time, 10-11pm, corrected for chronotype), 13 applied...
REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares dream-enacting behavior, is considered as a possible precursor neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) known to be capable provoking RBD-like by apneic event related arousals. The two pathologies must coincide in relevant number individuals because overlapping prevalence similar age groups. Until now RBD coexisting OSAS are rarely described scientific literature and fact mimicking...
Abstract Under entrained conditions, the accumulation of homeostatic sleep pressure in evening is opposed by a strong circadian arousal signal prior to dim light melatonin onset, called Wake Maintenance Zone (WMZ). This study aimed at investigating impact WMZ on different cognitive performance tests, as well subjective and objective sleepiness. Twelve young male participants completed constant routine protocol with 40 h extended wakefulness that included two WMZs. Cognitive tests saliva...
A method for the automatic detection of episodes wakefulness during sleep is presented. The algorithm based on evaluation alpha slow-wave index (ASI), a measure that has been developed to detect fluctuations vigilance in daytime pharmaco-electroencephalogram studies. Its application data was validated with polysomnographic recordings from 16 elderly insomniacs and young healthy subjects. rate agreement between computerized procedure visual scoring 94.0% 96.9% decision criterion used by...
<b><i>Introduction:</i></b> REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD characterized by progressive decline dopamine (DA) in the striatum. Here we report surprising increase DA transporter density over successive years an RBD patient treated with melatonin. <b><i>Case Presentation:</i></b> A then 72-year-old man was clinically suspected to suffer from 2011. scintigraphy...