A5006176316- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Lysosomal Storage Disorders Research
- Balance, Gait, and Falls Prevention
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Inflammatory Bowel Disease
- Diabetic Foot Ulcer Assessment and Management
- EEG and Brain-Computer Interfaces
- Microscopic Colitis
- Social Representations and Identity
- Multisensory perception and integration
- Dysphagia Assessment and Management
- Olfactory and Sensory Function Studies
- Ginkgo biloba and Cashew Applications
- Psychological Testing and Assessment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal motility and disorders
Southmead Hospital
2020-2023
Torbay Hospital
2022
North Bristol NHS Trust
2018-2021
University of Bristol
2017-2021
University of Oxford
2013-2020
Parkinson's UK
2014-2020
John Radcliffe Hospital
2012-2020
National Health Service
2020
Oxford University Hospitals NHS Trust
2014-2019
Aston University
2018
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, potentially intervene neuroprotective therapy. For future trials, it essential accurately estimate phenoconversion rate identify potential predictors phenoconversion. study assessed the disease risk neurodegeneration in large multicentre cohort...
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies Parkinson's disease patients. This can Dementia sensitivities of 92% 95%, respectively, an overall specificity 100% when compared Alzheimer control fluid. Patients neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest...
To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- sex-matched healthy controls (HC), validate findings separate cohort participants PD.Participants were scanned resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. maps between 19...
ABSTRACT The impact of Parkinson's disease (PD) dementia is substantial and has major functional socioeconomic consequences. Early prediction future cognitive impairment would help target interventions. Montreal Cognitive Assessment (MoCA), the Mini‐Mental State Examination (MMSE), fluency tests were administered to 486 patients with PD within 3.5 years diagnosis, results compared those from 141 controls correcting for age, sex, educational years. Eighteen‐month longitudinal assessments...
<h3>Background</h3> Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson9s disease (PD). Although the brainstem structures responsible for symptoms of RBD correspond to premotor stages PD, association motor and non-motor features early PD remains unclear. <h3>Methods</h3> The study evaluated 475 within 3.5 years diagnosis presence probable (pRBD) using Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist a trained research nurse...
Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate baseline clinical characteristics RBD and evaluate risk stratification models.Clinical assessments were performed in 171 RBD, 296 control, 119 untreated Parkinson's (PD) participants. Putative measures assessed as predictors neurodegeneration, Movement Disorders Society (MDS) criteria for PD applied. Participants screened common leucine-rich repeat...
See Postuma (doi:10.1093/aww131) for a scientific commentary on this article. Resting state functional magnetic resonance imaging dysfunction within the basal ganglia network is feature of early Parkinson's disease and may be diagnostic biomarker dysfunction. Currently, it unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder, condition associated with high rate future conversion to disease. In study, we explore utility resting detect...
<h3>Objective</h3> We sought to identify motor features that would allow the delineation of individuals with sleep study-confirmed idiopathic REM behavior disorder (iRBD) from controls and Parkinson disease (PD) using a customized smartphone application. <h3>Methods</h3> A total 334 PD, 104 iRBD, 84 control participants performed 7 tasks evaluate voice, balance, gait, finger tapping, reaction time, rest tremor, postural tremor. Smartphone recordings were collected both in clinic at home...
This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data 344 iRBD patients 256 controls for centralized analysis. images were semiquantified using DaTQUANTTM, obtaining putamen caudate specific non-displaceable binding ratios (SBRs). The following variables also...
Background: Within Parkinson's there is a spectrum of clinical features at presentation which may represent sub-types the disease.However no widely accepted consensus how best to group patients.Objective: Use data-driven approach unravel any heterogeneity in phenotype well-characterised, population-based incidence cohort.Methods: 769 consecutive patients, with mean disease duration 1.3 years, were assessed using broad range motor, cognitive and non-motor metrics.Multiple imputation was...
Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate processes accessible patient cells, we studied blood mononuclear cells recently diagnosed PD patients and rapid eye movement-sleep behavior disorder who have greatly increased risk developing PD. We hypothesized that may recapitulate cellular pathology found the brain investigated these for mitochondrial dysfunction oxidative stress.
Resting state fMRI (rfMRI) is gaining in popularity, being easy to acquire and with promising clinical applications. However, rfMRI studies, especially those involving groups, still lack reproducibility, largely due the different analysis settings. This particularly important for development of imaging biomarkers. The aim this work was evaluate reproducibility our recent study regarding functional connectivity basal ganglia network early Parkinson's disease (PD) (Szewczyk-Krolikowski et al.,...
ABSTRACT Nonmotor symptoms (NMS) are an important prodromal feature of Parkinson's disease (PD). However, their frequency, treatment rates, and impact on health‐related quality life (HRQoL) in the early motor phase is unclear. Rates NMS enriched at‐risk populations, such as first‐degree PD relatives, have not been delineated. We assessed cohort PD, relatives control subjects to address these questions. In total, 769 population‐ascertained within 3.5 years diagnosis, 98 287 were at baseline...
<h3>Objective</h3> To describe the prevalence, natural history, and risk factors for impulse control behaviors (ICBs) among people with Parkinson disease (PD), those REM sleep behavior disorder (RBD), controls. <h3>Methods</h3> Participants early PD (within 3.5 years of diagnosis), RBD, controls were clinically phenotyped screened ICBs longitudinally (with Questionnaire Impulsivity in Parkinson9s Disease). ICB-positive individuals invited a semistructured interview, repeated 1 year later....
Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order assess whether changes within basal ganglia network (BGN) are specific or relate neurodegeneration generally, BGN connectivity was assessed in 32 patients with PD, 19 healthy controls and 31 Alzheimer's (AD). Voxel-wise comparisons demonstrated decreased when compared AD controls. No significant were seen AD, Moreover, measures extracted from...
Abstract Hippocampal theta‐band oscillations are thought to facilitate the co‐ordination of brain activity across distributed networks, including between hippocampus and prefrontal cortex (PFC). Impairments in hippocampus‐PFC functional connectivity implicated schizophrenia associated with a polymorphism within ZNF804A gene that shows genome‐wide significant association schizophrenia. However, mechanisms by which affects unknown. We used multimodal imaging approach investigate impact on...
Background:Patients with REM sleep behavior disorder (RBD) have a high risk of developing PD, and thus can be used to study prodromal biomarkers. RBD has been associated changes in gait; quantifying these using wearable technology is promising; however, most data are obtained clinic al settings precluding pragmatic application. Objective:We aimed investigate if wearable-based, real-world gait monitoring detect early discriminate individuals from controls, explore relationships between...
Individuals with REM sleep behaviour disorder are at significantly higher risk of developing Parkinson's disease. Here we examined visual short-term memory deficits—long associated disease—in patients without disease using a novel task that measures recall precision. Visual for sequentially presented coloured bars different orientation was assessed in 21 polysomnography-proven idiopathic disorder, 26 cases early and healthy controls. Three tasks the same stimuli controlled attentional...
Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability developing PD in future. Neuropsychiatric problems are common RBD, but apathy has not previously been detailed this key prodromal population.