A5000733151- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Diet and metabolism studies
- Electrochemical Analysis and Applications
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Folate and B Vitamins Research
- Anesthesia and Neurotoxicity Research
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Medical Imaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- HIV Research and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Molecular Sensors and Ion Detection
- Biotin and Related Studies
- Genetic Neurodegenerative Diseases
Florida International University
2016-2024
Johns Hopkins University
2006-2019
Government of Western Australia Department of Health
2019
Columbia University
2010-2016
In-Q-Tel
2013
University of Wisconsin–Madison
2008
University of Baltimore
1985-2007
University of Colorado Denver
1999
Indiana University – Purdue University Fort Wayne
1991
Ball State University
1991
Children with rare, relapsed or refractory cancers often face limited treatment options, and few predictive biomarkers are available that can enable personalized recommendations. The implementation of functional precision medicine (FPM), which combines genomic profiling drug sensitivity testing (DST) patient-derived tumor cells, has potential to identify options when standard-of-care is exhausted. goal this prospective observational study was generate FPM data for pediatric patients cancer....
Abstract Synthetic triterpenoids have been developed, which are potent inducers of cytoprotective enzymes and inhibitors inflammation, greatly improving on the weak activity naturally occurring triterpenoids. An imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), has previously shown to potently protect against hepatic tumorigenesis, acting in part by inducing genes through Keap1-Nrf2-antioxidant response element (ARE) signaling....
Abstract: The peripheral benzodiazepine receptor (PBR) is currently used as a marker of inflammation and gliosis following brain injury. Previous reports suggest that elevated PBR levels in injured tissue are specific to activated microglia infiltrating macrophages. We have produced hippocampal lesions using the neurotoxicant trimethyltin (TMT) examine cellular subcellular nature response. Degenerating, argyrophilic pyramidal neurons were observed hippocampus at 2 14 days after TMT exposure....
Abstract Long‐term deficits in cognitive function are the principal effects of lead (Pb 2+ ) exposure children and can be modeled experimental animals. Current therapeutic approaches treatment childhood Pb intoxication not effective reversing learning once they have occurred. We report that environmental enrichment reverses long‐term spatial produced by developmental rats. Enhanced performance ‐exposed animals reared an enriched environment was associated with recovery N‐ methyl‐ D...
Human exposure to neurotoxic metals is a global public health problem. Metals which cause neurological toxicity, such as lead (Pb) and manganese (Mn), are of particular concern due the long-lasting possibly irreversible nature their effects. Pb in childhood can result cognitive behavioural deficits children. These effects persist into adulthood even after has been reduced or eliminated. While Mn an essential element human diet serves many cellular functions body, elevated levels Parkinson's...
Manganese (Mn) is an essential metal and has important physiological functions for human health. However, exposure to excess levels of Mn in occupational settings or from environmental sources been associated with a neurological syndrome comprising cognitive deficits, neuropsychological abnormalities parkinsonism. Historically, studies on the effects humans experimental animals have concerned basal ganglia dopaminergic system as it relates movement abnormalities. emerging are beginning...
Abstract The long‐term consequences of chronic manganese (Mn) exposure on neurological health is a topic great concern to occupationally‐exposed workers and in populations exposed moderate levels Mn. We have performed comprehensive assessment Mn effects dopamine (DA) synapse markers using positron emission tomography (PET) the non‐human primate brain. Young male Cynomolgus macaques were given weekly i.v. injections 3.3–5.0 mg Mn/kg ( n = 4), 5.0–6.7 5), or 8.3–10.0 3) for 7–59 weeks received...
Microglia, the resident immune cells of central nervous system, play an important role in brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single repeated traumatic brain injury, possibly through sports-related concussive subconcussive injuries. Limited vivo imaging studies months years individuals experience a moderate severe suggest widespread persistent activation, but there little study glial cell activity...