A5103202782- Hematopoietic Stem Cell Transplantation
- Child and Adolescent Health
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Healthcare Systems and Technology
- Pharmaceutical studies and practices
- Emergency and Acute Care Studies
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Hospital Admissions and Outcomes
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Nursing Roles and Practices
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Statistical Methods in Clinical Trials
- Vaccine Coverage and Hesitancy
- Delphi Technique in Research
- Complement system in diseases
- Polyomavirus and related diseases
- Healthcare Operations and Scheduling Optimization
- Intramuscular injections and effects
University of North Carolina Hospitals
2012-2023
University of North Carolina at Chapel Hill
2014-2023
University of North Carolina Health Care
2012-2021
UNC Lineberger Comprehensive Cancer Center
2016-2019
Johns Hopkins Hospital
2006
Balfour Hospital
2001
Rotherham General Hospital
2001
Research Complex at Harwell
2001
Waikato Hospital
1997
Ontario Institute for Cancer Research
1985
Purpose Appropriate use of oral chemotherapy is a challenge for patients and clinicians. The purpose this study was to analyze cancer patients’ chemotherapies identify opportunities improve adherence. Methods We developed 30-question survey address frequency reasons reducing/skipping doses; sources information use; perceived importance food–drug effects; ease understanding labeling directions. Results Ninety-three taking with chronic myeloid leukemia, renal cell carcinoma, breast cancer,...
Study Objective Intravenous immunoglobulin ( IVIG ) is a weight‐based therapy used to treat and prevent infections in patients with hematologic malignancies. doses were calculated traditionally using actual body weight ABW ). However, limited pharmacokinetic data suggest dosing strategies ideal IBW or adjusted (adj BW may be appropriate given the small volume of distribution . Our objective was compare effectiveness precision‐dosing strategy adj traditional‐dosing for malignancies those...
This study seeks to evaluate the impact of pharmacists' involvement in care patients undergoing bone marrow transplantation (BMT).This was a three-phase study. In phase 1, inpatient and outpatient pharmacist encounters were totaled services provided translated revenue generated from prescription billing charges. 2, activities interventions associated with time savings estimated by providers. 3, providers surveyed assess their expectations, experiences, value perceptions pharmacists.A...
Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well a narrow therapeutic index, and therefore requires drug monitoring. Germline mutations in cytochrome P450 isoforms 4 5 genes (CYP3A4/5) the ATP-binding cassette B1 gene (ABCB1) may contribute to interindividual tacrolimus PK which impact clinical outcomes among allogeneic hematopoietic stem cell transplantation (HSCT) patients. In this study, 252 adult patients who received for acute graft versus host disease...
A paucity of data currently exists regarding drug–drug interaction (DDI) with tacrolimus and isavuconazole coadministration. Current literature provides conflicting recommendations on whether an empiric dose reduction is necessary when coadministered isavuconazole. 47-year-old African American female acute lymphoblastic leukemia underwent allogenic stem cell transplant (alloSCT) was subsequently placed routine posttransplant therapy including for immunosuppression posaconazole antifungal...
Introduction Treatment with chimeric antigen receptor modified T cells targeting CD30 (CD30.CAR-Ts) without lymphodepletion was found to be safe preliminary efficacy in patients (pts) relapsed/refractory (r/r) CD30+ lymphomas (Ramos et al., JCI 2017). We report the results of a phase 1b/2 trial CD30.CAR-Ts infused after pts r/r Hodgkin (HL) and Non-Hodgkin lymphoma (NHL). Objectives The primary objective Ib portion study determine 2 dose using standard 3+3 design. Methods Pts ≥ 18 years HL...
Targeted busulfan dosing helps limit chemotherapy-related toxicity and optimize disease outcomes in hematopoietic stem cell transplantation (HCT). The objective of this study was to evaluate exposure from a pharmacokinetic (PK)-guided strategy using test dose. This retrospective evaluation included adult patients who underwent HCT at our institution with busulfan-based myeloablative (>9 mg/kg) conditioning between January 2014 October 2015. A weight-based dose 0.8 mg/kg used PK assessments...
The hypothesis that direct nursing hours correlate with the cost of a patient stay in intensive care was tested. One hundred and thirty-nine patients were studied data collected included: (a) applied to each patient; (b) daily TISS score: (c) detailed costing (all costs are shown N.Z.$). There strong correlation between total per (r2 = 0.98) (total 54 x + 344). Also existed scores 0.96) 67.13 TISS). Direct offer relatively simple logical method allocating patient.
6042 Background: Appropriate use of oral antineoplastics (OA), especially those with a food-effect, is challenge for patients and clinicians. Patient adherence essential to optimize outcomes, minimize toxicity, bias in clinical trials, reduce health care costs. As the OA grows, due narrow therapeutic margin, it critical understand barriers patient adherence. The purpose this study was analyze cancer patients’ OAs identify opportunities improve Methods: We developed tested 30-question survey...
Given the variation in clinical practice, a clinician-centric, standardized process to implement and validate pharmacy outcome measures was developed.Four specialty clinics with embedded clinic-based pharmacists underwent an iterative define, refine, build of electronic health record functionality for measure data collection reporting. Starting list identified measures, clinic workgroups met discuss each identify gaps implementation. Information technology experts created documentation forms...
There is minimal available guidance on the process for selection of clinical outcomes measures to demonstrate impact clinic-based pharmacists (CBPs) despite an increased need and desire data. The overall aims this project were (1) develop a standardized identifying impacted by CBPs (2) identify prioritize potential track within 4 specialty clinic pilot sites.To identification prioritization measures, consecutive Plan-Do-Study-Act (PDSA) cycles performed with different clinics serving as...
While objective physical barriers affecting outcomes for hematopoietic stem cell transplant (HSCT) candidates exist, psychosocial with potential consequences are more subjective and harder to quantify but also important determining outcomes. Psychosocial may be due limited social support, constrained resources, and/or impaired coping mechanisms. At our institution, despite obtaining a comprehensive evaluation pre-transplant, the approach management of identified problems varied between...
Clinical Pharmacology & Therapeutics (1999) 65, 181–181; doi: