A5086842158- Cancer Cells and Metastasis
- Mechanisms of cancer metastasis
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- PARP inhibition in cancer therapy
- Kruppel-like factors research
- RNA Interference and Gene Delivery
- RNA regulation and disease
- FOXO transcription factor regulation
- Chromatin Remodeling and Cancer
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Biomarkers in Disease Mechanisms
- Microtubule and mitosis dynamics
Florida International University
2016-2024
University of Miami
2011-2021
Cancer Institute (WIA)
2021
Sylvester Comprehensive Cancer Center
2011-2021
Universidad de Granada
2018
Whitehead Institute for Biomedical Research
2017
Harvard University
2017
Brigham and Women's Hospital
2017
Boston Children's Hospital
2017
University of California, Irvine
2012
Children with rare, relapsed or refractory cancers often face limited treatment options, and few predictive biomarkers are available that can enable personalized recommendations. The implementation of functional precision medicine (FPM), which combines genomic profiling drug sensitivity testing (DST) patient-derived tumor cells, has potential to identify options when standard-of-care is exhausted. goal this prospective observational study was generate FPM data for pediatric patients cancer....
Abstract Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but mechanisms by which it contributes to development patient outcome have yet be elucidated. Here, we examined effects coculturing human-derived adipocytes with established primary breast cells tumorigenic potential. We found that interaction between increased secretion proinflammatory cytokines. Prolonged culture or cytokines proportion...
Tumours are comprised of a highly heterogeneous population cells, which only small subset stem-like cells possess the ability to regenerate tumours in vivo. These cancer stem (CSCs) represent significant clinical challenge as they resistant conventional therapies and play essential roles metastasis tumour relapse. Despite this realization great interest CSCs, it has been difficult develop CSC-targeted treatments due our limited understanding CSC biology. Here, we present evidence that...
Although chemotherapies kill most cancer cells, stem cell-enriched survivors seed metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are enriched for tumor cells. Here, we tested if inhibition of DOT1L, an epigenetic regulator normal tissue stem/progenitor populations, would target TNBC cells.Effects DOT1L by EPZ-5676 on cell properties were three lines four patient-derived xenograft (PDX) models isolated (CSC)-enriched ALDH1+ ALDH1- populations. RNA...
Rational targeted therapies are needed for treatment of ovarian cancers. Signaling kinases Src and MAPK activated in high-grade serous cancer (HGSOC). Here, we tested the frequency activation both HGSOC therapeutic potential dual kinase inhibition.
Research Article27 August 2013Open Access Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics γ-secretase inhibitor drug responses Diana J. Azzam Braman Family Breast Cancer Institute, Sylvester Comprehensive Center, University of Miami Miller School Medicine, Miami, FL, USA Department Biochemistry Molecular Biology, Search for more papers by this author Dekuang Zhao Sheila David Fuente Biology Program, Jun Sun Andy Minn Radiation...
More effective, less toxic treatments for recurrent ovarian cancer are needed. Although more than 60% of cancers express the estrogen receptor (ER), ER-targeted drugs have been disappointing due to drug resistance. In other estrogen-sensitive cancers, activates Src phosphorylate p27 promoting its degradation and increasing cell-cycle progression. Because is activated in most we investigated whether combined ER blockade by saracatinib fulvestrant would circumvent antiestrogen resistance.ER...
A precision medicine approach is appealing for use in AML due to ease of access tumor samples and the significant variability patients' response treatment. Attempts establish a platform AML, however, have been unsuccessful, at least part small compound panels having relatively slow turn over rates, which restricts scope treatment delays its onset. For this pilot study, we evaluated cohort 12 patients with refractory using an ex vivo drug sensitivity testing (DST) platform. Purified blasts...
Abstract Resistance to hormonal therapies is a major clinical problem in the treatment of estrogen receptor α–positive (ERα+) breast cancers. Epigenetic marks, namely DNA methylation cytosine at specific CpG sites (5mCpG), are frequently associated with ERα+ status human Therefore, ERα may regulate gene expression part via methylation. This hypothesis was evaluated using panel cancer cell line models antiestrogen resistance. Microarray profiling used identify genes normally silenced cells...
Abstract In the brain neuropil, translocator protein 18 kDa (TSPO) is a stress response that upregulated in microglia and astrocytes diverse central nervous system pathologies. TSPO widely used as biomarker of neuroinflammation preclinical clinical neuroimaging studies. However, there paucity knowledge on function(s) glial cells. this study, we explored putative interaction between NADPH oxidase 2 (NOX2) microglia. We found associates with gp91 phox p22 , principal subunits NOX2 primary...
Treatment options for patients with platinum-resistant ovarian cancer are generally palliative in nature and rarely have realistic potential to be curative. Because many recurrent receive aggressive chemotherapy prolonged periods, sometimes continuously, therapy-related toxicities a major factor treatment decisions. The use of ex vivo drug sensitivity screens has the improve by providing personalized plans thus reducing toxicity from unproductive therapy attempts.We evaluated responses set...
1551 Background: Pediatric and adult patients with rare, relapsed, or refractory cancers often have few treatment options. Precision medicine approaches are the first strategy used to identify salvage therapy options when standard treatments fail. Despite significant clinical benefit advanced cancer patients, multiple genomics precision trials revealed important constraints for that lack matched mutations biomarkers highlighted challenges in drug accessibility associated novel targeted...
Abstract Translocator protein 18 kDa (TSPO) is a well-known outer mitochondrial membrane and it widely used as biomarker of neuroinflammation brain injury. Although thought that TSPO plays key roles in multitude host cell functions, including steroid biosynthesis, apoptosis, generation reactive oxygen species, proliferation, some these functions have recently been questioned. Here, we report the unexpected finding circulating immune cells differentially express basal levels on their surface,...
Glioblastoma (GBM) is the most common primary brain tumor in adults, with few available therapies and a five-year survival rate of 7.2%. Hence, strategies for improving GBM prognosis are urgently needed. The translocator protein 18kDa (TSPO) plays crucial roles essential mitochondria-based physiological processes validated biomarker neuroinflammation, which implicated progression. TSPO gene has germline single nucleotide polymorphism, rs6971, SNP Caucasian population. High expression...