A5002172208- Microtubule and mitosis dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive Biology and Fertility
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- Cellular Mechanics and Interactions
- Plant Molecular Biology Research
- Pluripotent Stem Cells Research
- Advanced MIMO Systems Optimization
- Insect and Arachnid Ecology and Behavior
- Chromosomal and Genetic Variations
- Protist diversity and phylogeny
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Cooperative Communication and Network Coding
- Animal Behavior and Reproduction
- Cellular transport and secretion
- Spectroscopy and Laser Applications
- Muscle Physiology and Disorders
- Insect Utilization and Effects
- Advanced Wireless Communication Techniques
- RNA Research and Splicing
- Mitochondrial Function and Pathology
Institut Jacques Monod
2014-2025
Université Paris Cité
2014-2025
Centre National de la Recherche Scientifique
2015-2025
Sorbonne Paris Cité
2012-2022
Centre Interdisciplinaire de Recherche en Biologie
2022
Université du littoral côte d'opale
2022
Churchill Hospital
2021
University of Oxford
2021
Douglas Mental Health University Institute
2021
Institut Pasteur de Lille
2021
"Reactionary democracy: how racism and the populist far right became mainstream." Social Movement Studies, ahead-of-print(ahead-of-print), pp. 1–2
Spindle formation is essential for stable inheritance of genetic material. Experiments in various systems indicate that Ran GTPase crucial meiotic and mitotic spindle assembly. Such an important role chromatin-induced assembly was initially demonstrated Xenopus laevis egg extracts. However, the requirement RanGTP living cells has not been shown. In this study, we used a fluorescence resonance energy transfer probe to measure RanGTP-regulated release importin beta. A gradient established...
In this paper, the capacity-achieving input covariance matrices for coherent block-fading correlated multiple output (MIMO) Rician channels are determined. contrast with Rayleigh and uncorrelated cases, no closed-form expressions eigenvectors of optimum matrix available. Classically, both eigenvalues computed numerically corresponding optimization algorithms remain computationally very demanding. asymptotic regime where number transmit receive antennas converge to infinity at same rate, new...
During cell division, spindle microtubules ensure an equal repartition of chromosomes between the two daughter cells. While kinetochore-dependent mechanisms that drive mitotic chromosome segregation are well understood, in oocytes most species atypical spindles assembled absence centrosomes entail poorly understood segregation. In particular, structure(s) responsible for force generation during meiotic separation is unclear. Using quantitative light microscopy, electron tomography,...
Centrosomes, the predominant sites of microtubule nucleation and anchorage, coordinate spindle assembly cell division in animal cells. At onset mitosis, centrioles accumulate microtubule-organizing pericentriolar material (PCM) a process termed centrosome maturation. To what extent maturation depends on continued activity mitotic regulators or presence has hitherto been unclear. Using C. elegans early embryo, we show that PCM expansion requires Polo-like kinase PLK-1 CEP192 (SPD-2 elegans),...
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Cytokinesis, the physical division of one cell into two, is thought to be fundamentally similar in most animal divisions and driven by constriction a contractile ring positioned controlled solely mitotic spindle. During asymmetric divisions, core polarity machinery (partitioning defective [PAR] proteins) controls unequal inheritance key fate determinants. Here, we show that asymmetrically dividing Caenorhabditis elegans embryos, cortical PAR proteins (including small guanosine triphosphatase...
In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation - essential to prevent miscarriage or developmental defects thus occur through atypical mechanisms that are not well characterized. Using quantitative in vitro vivo functional assays the C. elegans oocyte, we provide novel evidence kinesin-13 KLP-7 promotes destabilization of whole cellular microtubule network. By counteracting ectopic disorganization network, this function is strictly...
Vertebrate oocytes arrest in metaphase of the second meiotic division (MII), where they maintain a high cdc2/cyclin B activity and stable, bipolar spindle because cytostatic factor (CSF) activity. The Mos–MAPK pathway is essential for establishing CSF. Indeed, from mos−/− strain do not MII activate without fertilization, as Xenopus laevis injected with morpholino oligonucleotides directed against Mos. In oocytes, p90Rsk (ribosomal S6 kinase), MAPK substrate, main mediator CSF We show here...
Cytokinesis, the physical division of one cell into two, is powered by constriction an actomyosin contractile ring. It has long been assumed that all animal cells divide a similar molecular mechanism, but growing evidence suggests cytokinetic regulation in individual types more variation than previously realized. In four-cell Caenorhabditis elegans embryo, each blastomere distinct fate, specified conserved pathways. Using fast-acting temperature-sensitive mutants and acute drug treatment, we...
Signaling by the centrosomal asters and spindle midzone coordinately directs formation of cytokinetic furrow. Here, we explore contribution analyzing consequences altering interaster distance during first cytokinesis Caenorhabditis elegans embryo. Delaying aster separation, using TPXL-1 depletion to shorten metaphase spindle, leads a corresponding delay in furrow formation, but results single that ingresses at normal rate. Preventing simultaneously inhibiting Galpha signaling-based cortical...
During cell division, chromosome segregation is orchestrated by a microtubule-based spindle. Interaction between spindle microtubules and kinetochores central to the bi-orientation of chromosomes. Initially dynamic allow assembly kinetochore attachments, which essential for alignment, are eventually stabilized efficient sister chromatids homologous chromosomes during mitosis meiosis I, respectively. Therefore, precise control microtubule dynamics utmost importance meiosis. Here, we study...