A5055677795- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Cardiovascular Disease and Adiposity
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Motor Control and Adaptation
- Multisensory perception and integration
- Action Observation and Synchronization
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Cell Image Analysis Techniques
- NMR spectroscopy and applications
- Neuroscience and Music Perception
- Ocular and Laser Science Research
- Lanthanide and Transition Metal Complexes
- Advanced Sensor and Energy Harvesting Materials
- Pain Mechanisms and Treatments
- Music Therapy and Health
- Aesthetic Perception and Analysis
Ruhr University Bochum
2014-2021
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
BG University Hospital Bergmannsheil Bochum
2014-2020
Klinik und Poliklinik für Neurologie
2019
IFB Adiposity Diseases
2017-2019
University Hospital Leipzig
2018
Leipzig University
2017
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Learning mechanisms are based on synaptic plasticity processes. Numerous studies suggest that the regulation of inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays a central role maintaining delicate balance inhibition and excitation. However, in humans, link between learning outcome GABA levels has not been shown so far. Using magnetic resonance spectroscopy prior to after repetitive tactile stimulation, we show here baseline GABA+ predict changes perceptual outcome. Although no...
There is a growing interest in identifying the neural mechanisms by which human brain allows for improving performance. Tactile perceptual measurements, e.g. two-point discrimination (2ptD), can be used to investigate of perception as well improvement. Improvement induced practice-independent manner, tactile domain through repetitive somatosensory stimulation (rSS). With respect perception, role cortical excitability and activation within cortex has been investigated extensively. However,...
Background The hardware and software differences between MR vendors individual sites influence the quantification of spectroscopy data. An analysis a large data set may help to better understand sources total variance in quantified metabolite levels. Purpose To compare multisite quantitative brain acquired healthy participants at 26 by using vendor-supplied single-voxel point-resolved (PRESS) sequence. Materials Methods protocol acquire short-echo-time PRESS from midparietal region was...
Abstract Although we use our visual and tactile sensory systems interchangeably for object recognition on a daily basis, little is known about the mechanism underlying this ability. This study examined how 3D shape features of objects form two congruent interchangeable perceptual spaces in healthy male female participants. Since active exploration plays an important role processing, virtual reality environment was used to visually explore called digital embryos without using sense. In...
Differences in γ-aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate behavioral performance over a number of tasks and cortical regions. These correlations appear be regionally functionally specific. In this study, we test the hypothesis that GABA will correlated within individuals for related regions—the left right sensorimotor cortex. addition, investigate whether is driven by bulk tissue composition. measurements using edited MRS data...
There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects morbidly obese individuals through the brain. Hypothalamic inflammation a well-recognized etiologic factor obesity pathogenesis and so represents potential target of RYGB, but clinical evidence support this limited. We therefore assessed hypothalamic T2-weighted signal intensities (T2W SI) fractional anisotropy (FA) values, 2 validated radiologic...
Abstract Background Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on test (TS). Using cutaneous electrical stimulation (PCES) as TS and cold water CS, relief was paralleled by decrease in evoked potentials (PCES-EPs). We now aimed to compare CPM with cognitive distraction PCES-induced PCES-EP amplitudes. Methods PCES performed using surface electrodes inducing sensation 60 (NRS 0–100) one hand. In crossover design healthy subjects (included: n...
Correlations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of brain provide a potent tool to delineate its functional architecture terms intrinsic connectivity (iFC). Still, it remains unclear how iFC is modulated during learning. We employed whole-brain resting-state magnetic resonance imaging prior and after training-independent repetitive sensory stimulation (rSS), which known induce somatosensory cortical reorganization....
Abstract Certain kinds of stimuli can be processed on multiple levels. While the neural correlates different levels processing (LOPs) have been investigated to some extent, most studies involve skills and/or knowledge already present when performing task. In this study we specifically sought identify an evolving skill that allows transition from perceptual a lexico‐semantic stimulus analysis. Eighteen participants were trained decode 12 letters Morse code presented acoustically inside and...
Previous magnetic resonance imaging (MRI) studies revealed structural-functional brain reorganization 12 months after gastric-bypass surgery, encompassing cortical and subcortical regions of all lobes as well the cerebellum. Changes in mean cluster-wise gray/white matter density (GMD/WMD) were correlated with individual loss body mass index (BMI), rendering BMI a potential marker widespread surgery-induced plasticity. Here, we investigated voxel-by-voxel associations between changes...
A distributed network including prefrontal and hippocampal regions is involved in context-related extinction learning as well renewal. Renewal describes the recovery of an extinguished response if context differs from recall. Animal studies have demonstrated that prefrontal, but not N-methyl-D-aspartate receptor (NMDAR) antagonism disrupted processing task context. However, human NMDAR are lacking, while yielded contradictory results other tasks. This fMRI study investigated role for...
Most of the occupational exposure limits (OELs) are based on local irritants. However, to much lower concentrations irritant substances can also lead health complaints from workers. Exposure irritants is often accompanied by strong unpleasant odors, and odors might have distracting effects hence pose a safety risk. The findings obtained in human studies with chemically sensitive, stressed, or anxious persons suggest that their ability direct attention away odorous focus cognitive task...
In addition to its role in visuospatial navigation and the generation of spatial representations, recent years, hippocampus has been proposed support perceptual processes. This is especially case where high-resolution details, form fine-grained relationships between features such as angles components a visual scene, are involved. An unresolved question how, domain, perspective-changes differentiated from allocentric changes these perceived feature relationships, both which may be argued...