A5077607235- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- Prosthetics and Rehabilitation Robotics
- Vestibular and auditory disorders
- Neural and Behavioral Psychology Studies
- Burn Injury Management and Outcomes
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Muscle Physiology and Disorders
- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Neuroscience and Neural Engineering
- Nerve Injury and Rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Visual perception and processing mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Cervical and Thoracic Myelopathy
- Trigeminal Neuralgia and Treatments
- Traumatic Brain Injury Research
BG University Hospital Bergmannsheil Bochum
2012-2021
Ruhr University Bochum
2009-2021
Reorganization in the sensorimotor cortex accompanied by increased excitability and enlarged body representations is a consequence of spinal cord injury (SCI). Robotic-assisted bodyweight supported treadmill training (BWSTT) was hypothesized to induce reorganization improve walking function.
Objective Age and lesion level are believed to represent outcome predictors in rehabilitation of patients with chronic spinal cord injury (SCI). The Hybrid Assistive Limb (HAL) exoskeleton enables perform a voluntary controlled gait pattern via an electromyography-triggered neuromuscular feedback system, has been introduced as temporary training tool SCI. aim this prospective pre- postintervention study was examine functional outcomes function age incomplete SCI (iSCI) or complete (cSCI)...
Background: The exoskeleton HAL (hybrid assistive limb) has proven to improve walking functions in spinal cord injury and chronic stroke patients when using it for body-weight supported treadmill training (BWSTT). Compared with other robotic devices, offers the possibility initiate movements actively. Previous studies on did not compare HAL-BWSTT conventional physiotherapy (CPT). Therefore, we performed a crossover clinical trial comparing CPT hemiparesis, HALESTRO study. Our hypothesis was...
Studies on noninvasive motor cortex stimulation and learning demonstrated cortical excitability as a marker for effect. Transcranial direct current (tDCS) is non-invasive tool to modulate excitability. It yet unknown how tDCS-induced changes perceptual in visual correlate. Our study aimed examine the influence of tDCS healthy humans. Additionally, we measured primary (V1). We hypothesized that anodal would improve cathodal have minor or no effects learning. Anodal, sham were applied over V1...
Purpose: Exoskeletons have been developed for rehabilitation of patients with walking impairment due to neurological disorders. Recent studies shown that the voluntary-driven exoskeleton HAL® (hybrid assistive limb) can improve functions in spinal cord injury and stroke. The aim this study was assess safety effects on function supported treadmill therapy limb-girdle muscular dystrophy (LGMD). Materials Methods: Three LGMD received 8 weeks training 3 times a week. Outcome parameters were...
Repetitive sensory stimulation (RSS) adapts the timing of protocols used in cellular studies to induce synaptic plasticity. In healthy subjects, RSS leads widespread sensorimotor cortical reorganization paralleled by improved behavior. Here, we investigated whether reduces upper limb impairment patients with subacute stroke more effectively than conventional therapy. A single-blinded sham-controlled clinical trial assessed effectiveness treating deficits limbs. Patients unilateral ischemic...
Longitudinal prospective study.Whether 1-year HAL-BWSTT of chronic spinal cord injured patients can improve independent ambulated mobility further as a function training frequency, after an initial 3-month period.Eight with SCI were enrolled. They initially received full standard physical therapy and neurorehabilitation in the acute/subacute posttrauma phase. During this trial, all first underwent daily (5 per week) for 12 weeks. Subsequently, these performed 40-week session frequency either...
Transcranial direct current stimulation (tDCS) is a noninvasive method that has been shown to modulate the excitability of motor and visual cortices in human subjects polarity dependent manner previous studies. The aim our study was investigate whether anodal cathodal tDCS can also be used primary somatosensory cortex (S1). We measured paired-pulse suppression (PPS) evoked potentials 36 right-handed volunteers before after anodal, or sham over right non-dominant S1. Paired-pulse median nerve...
Since 2000/2001, no large-scale prospective studies addressing traumatic brain injury (TBI) epidemiology in Germany have been published. Our aim was to look for a possible shift TBI described other European countries, changes management and identify predictors of 1-year outcome especially patients with mild TBI.Observational cohort study.All suffering from any degree between 1 October 2014 30 September 2015, who arrived one the seven participating BG hospitals within 24 hours after trauma,...
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative motoneuron disease. As previous studies reported alterations in motor cortex excitability, we evaluate excitability changes somatosensory system. Methods: We examined 15 ALS patients and healthy controls. Cortical was assessed using paired evoked potentials of median nerves. To determine disease severity functional impairment, muscle strength revised ALS-Functional Rating Scale (ALSFRS-R). Results: found...
Repetitive transcranial magnetic stimulation (rTMS) is able to induce changes in neuronal activity that outlast stimulation. The underlying mechanisms are not completely understood. They might be analogous long-term potentiation or depression, as the duration of effects seems implicate synaptic plasticity. Norepinephrine (NE) has been shown play a crucial role plasticity healthy and injured human brain. Atomoxetine (ATX) other NE reuptake inhibitors have increase excitability different...
Most of the occupational exposure limits (OELs) are based on local irritants. However, to much lower concentrations irritant substances can also lead health complaints from workers. Exposure irritants is often accompanied by strong unpleasant odors, and odors might have distracting effects hence pose a safety risk. The findings obtained in human studies with chemically sensitive, stressed, or anxious persons suggest that their ability direct attention away odorous focus cognitive task...
A 57-year-old woman suffering from limb-girdle muscular dystrophy type 2I (LGMD, fukutin-related protein gene mutation) took part in body-weight supported treadmill therapy with the voluntary driven exoskeleton HAL®. First clinical signs were evident 11 years ago. The diagnosis has been determined genetically 2009. Clinical examination showed floppy quadriparesis typical proximal pronouncement (MRC 3-4/5), positive Trendelenburg sign bilateral and lumbar hyperlordosis. Due to dystrophy,...