A5060130882- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Musculoskeletal pain and rehabilitation
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Spinal Cord Injury Research
- Botulinum Toxin and Related Neurological Disorders
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cerebral Palsy and Movement Disorders
- Tactile and Sensory Interactions
- Neuroscience and Neuropharmacology Research
- Prosthetics and Rehabilitation Robotics
- Psychosomatic Disorders and Their Treatments
- Medical Practices and Rehabilitation
- Neurological disorders and treatments
BG University Hospital Bergmannsheil Bochum
2015-2024
Ruhr University Bochum
2012-2024
LWL-Universitätsklinikum Bochum
2013
National Institute of Neurological Disorders and Stroke
2007
LWL-Universitätsklinik Hamm
2004
Abstract Patients with complex regional pain syndrome (CRPS) and intractable showed a shrinkage of cortical maps on primary (SI) secondary somatosensory cortex (SII) contralateral to the affected limb. This was paralleled by an impairment two‐point discrimination thresholds. Behavioral treatment over 1 6 months consisting graded sensorimotor retuning led persistent decrease in intensity, which accompanied restoration impaired tactile regaining map size SI SII. suggests that reversal...
The pharmacological basis of perceptual learning and associated cortical reorganizations remains elusive. We induced by Hebbian coactivation the skin tip right index finger in humans. Under placebo, tactile two-point discrimination was improved on coactivated but not left finger. This augmentation blocked an N-methyl-D-aspartate-receptor blocker, doubled amphetamine. No drug effects were found individual amount reorganization as assessed mapping somatosensory evoked potentials linearly...
<b><i>Background:</i></b> Complex regional pain syndrome type I (CRPS I) develops as a consequence of trauma affecting the limbs, without obvious nerve lesion. Its features include pain, edema, autonomic dysfunction, movement disorder, and trophic changes. CNS involvement is suggested by symptoms, but pathophysiology CRPS unknown. <b><i>Objective:</i></b> To assess excitability changes in motor cortex patients with I. <b><i>Methods:</i></b> The authors studied 25 unilateral involving hand...
We report experiments combining assessment of spatial tactile discrimination behavior and measurements somatosensory-evoked potentials in human subjects before after short-term plastic changes to demonstrate a causal link between the degree altered performance reorganization. Plastic were induced by Hebbian coactivation protocol simultaneous pairing stimuli. As result coactivation, thresholds lowered; however, amount improvement was variable across subjects. Analysis revealed significant,...
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to investigate mechanisms of brain functions and plasticity, but also as a promising new therapeutic tool. The effects rTMS depend on the intensity frequency consist changes cortical excitability, which often persists several minutes after termination rTMS. While these findings imply that processing can be altered by applying current pulses from outside brain, little known about how persistently affects learning...
Reorganization in the sensorimotor cortex accompanied by increased excitability and enlarged body representations is a consequence of spinal cord injury (SCI). Robotic-assisted bodyweight supported treadmill training (BWSTT) was hypothesized to induce reorganization improve walking function.
Phantom limb pain (PLP) associated neuroplastic changes are partly mediated by excitatory amino acids at NMDA receptor sites. This study was undertaken to deduce if NMDA-receptor antagonists may be effective in patients with chronic PLP. Therefore a four week double-blinded, randomized placebo-controlled trial performed evaluate the efficacy of 30 mg memantine/day, an orally administrable antagonist.Thirty-six patients, 18 per group, history least 12 months PLP and average 4 on 11-point...
The representations of the human hand in primary somatosensory cortex (SI) undergo continuous adaptational plastic processes, which arise from learning, altered use, or injury. resulting reorganization affects size, extent, and position cortical maps, parallels alterations tactile behavior indicating a close relationship between map changes perception. Here we investigate influence healthy aging on representation age-related performance. Using evoked potential mapping combination with...
The aim of this study was to examine the relationship between chronic neuropathic pain after incomplete peripheral nerve lesion, nociceptive due osteoarthritis, and excitability motor cortex assessed by transcranial magnetic stimulation (TMS). Hence in 26 patients with resulting from an isolated lesion median or ulnar (neuralgia), 20 painful osteoarthritis hand, 14 healthy control subjects, tested using paired-pulse TMS assess intracortical inhibition facilitation. These parameters were...
In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests dysfunction central motor-sensory circuits. The aim our present study was to assess possible excitability changes somatosensory system CRPS.We measured paired-pulse suppression evoked potentials 21 unilateral CRPS I involving hand. Eleven upper limb non-neuropathic origin and healthy subjects served as controls. Innocuous stimulation median...
Chronic neuropathic pain (CNP) is a common condition associated with spinal cord injury (SCI) and has been reported to be severe, disabling often treatment-resistant therefore remains clinical challenge for the attending physicians. The treatment usually includes pharmacological and/or nonpharmacological approaches. Body weight supported treadmill training (BWSTT) locomotion driven gait orthosis (DGO) have evolved over last decades are now considered an established part in rehabilitation of...
Abstract As a model for use‐dependent plasticity, the brains of professional musicians have been extensively studied to examine structural and functional adaptation unique requirements skilled performance. Here we provide combination data on motor performance hand representation in primary somatosensory cortex violin players, with aim assessing possible behavioural consequences sensorimotor cortical asymmetries. We 15 healthy right‐handed players 35 nonmusician controls. Motor asymmetry was...