A5105530230- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Amino Acid Enzymes and Metabolism
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- HIV-related health complications and treatments
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- HIV, Drug Use, Sexual Risk
- Obstructive Sleep Apnea Research
- Muscle Physiology and Disorders
- Malaria Research and Control
- Cytomegalovirus and herpesvirus research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
- Cerebral Palsy and Movement Disorders
- Muscle metabolism and nutrition
Neuroscience Research Australia
2016-2025
UNSW Sydney
2016-2025
Chelsea and Westminster Hospital NHS Foundation Trust
2013-2024
Hallym University
2024
Hallym University Kangnam Sacred Heart Hospital
2024
King's Cross Hospital
2018-2021
Universidad Nacional Autónoma de México
2021
St Vincent's Hospital
2015-2020
St Vincent's Hospital Sydney
2018-2020
Agence Nationale de Recherches sur le Sida et les Hépatites Virales
2017
Creatine supplementation is in widespread use to enhance sports-fitness performance, and has been trialled successfully the treatment of neurological, neuromuscular atherosclerotic disease. plays a pivotal role brain energy homeostasis, being temporal spatial buffer for cytosolic mitochondrial pools cellular currency, adenosine triphosphate its regulator, diphosphate. In this work, we tested hypothesis that oral creatine (5 g d(-1) six weeks) would intelligence test scores working memory...
Glutathione is important in the regulation of redox state, and a decline its tissue level has often been considered to be indicative increased oxidative stress diabetes. In this study diabetic rats, hepatic glutathione was normal unless food intake restricted. Thus, previous report reduction diabetes likely result deprivation rather than alone. contrast changes characteristic stress, efflux bile from animals significantly decreased, whereas mixed disulfides were unchanged,...
Human brain imaging has revealed that acute pain results from activation of a network regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In contrast, many investigations report little or no alteration in activity associated with chronic pain, particularly neuropathic pain. It been hypothesized misinterpretation thalamocortical activity, recent evidence altered rhythm individuals Indeed, it was suggested nearly four decades ago may be maintained by discrete...
Summary Neuropathic pain following spinal cord injury is associated with altered thalamic biochemistry, structure and function, which may disturb central processing play a key role in the persistent experience of pain. There increasing evidence relating changes to generation and/or maintenance neuropathic We have recently reported that orofacial anatomy, activity, result disturbed thalamocortical oscillatory circuits. Despite this evidence, it possible these are not responsible for presence...
<h3>Objectives</h3> The peripheral muscle pump is key in promoting cardiac filling during exercise, especially subjects who lack a subpulmonary ventricle (the Fontan circulation). A muscle-wasting syndrome exists acquired heart failure but has not been assessed subjects. We sought to investigate whether adults with the circulation exhibit reduced skeletal mass and/or metabolic abnormalities. <h3>Design and patients</h3> Sixteen New York Heart Association Class I/II (30±2 years) underwent...
Cardiovascular disease (CVD) and premature aging have been hypothesized as new risk factors for HIV associated neurocognitive disorders (HAND) in adults with virally-suppressed infection. Moreover, their significance relation to more classical HAND biomarkers remain unclear.92 HIV- infected (HIV+) stable on combined antiretroviral therapy (cART) 30 age-comparable HIV-negative (HIV-) subjects underwent (1)H Magnetic Resonance Spectroscopy (MRS) of the frontal white matter (targeting HIV,...
The role of glutamine and alanine transport in the recycling neurotransmitter glutamate was investigated Guinea pig brain cortical tissue slices prisms, cultured neuroblastoma astrocyte cell lines. ability exogenous (2 mm) to displace 13C label supplied as [3-13C]pyruvate, [2-13C]acetate, l-[3-13C]lactate, or d-[1-13C]glucose using NMR spectroscopy. Glutamine inhibited under quiescent depolarising conditions histidine, which shares most routes with glutamine, 2-(methylamino)isobutyric acid...
NMR spectroscopy was used to identify and quantify compounds in extracts prepared from mature trophozoite-stage Plasmodium falciparum parasites isolated by saponin-permeabilisation of the host erythrocyte. One-dimensional (1)H four two-dimensional techniques were more than 50 metabolites. The intracellular concentrations over 40 metabolites estimated spectra extraction methods: perchloric acid, methanol/water, methanol/chloroform/water, methanol alone. quantified included: majority...
Abstract Purpose: To investigate the anisotropic elasticity of soft tissues using MR elastography (MRE) combined with diffusion tensor imaging (DTI). Materials and Methods: The storage moduli parallel (μ ‖ ) perpendicular ⟂ to local fiber orientation were calculated assuming a transversely isotropic model. was provided by DTI. proposed technique validated against rheometry viscoelastic phantoms various volume fractions (V f = 0%, 15%, 35%) bovine skeletal muscle samples. Results: ratio /μ as...