An increased understanding of the relationship between subconcussive head impacts and near point convergence (NPC) ocular-motor function may be useful in delineating traumatic brain injury.To investigate whether repetitive during preseason football practice cause changes NPC.This prospective, observational study 29 National Collegiate Athletic Association Division I players included baseline practices (1 noncontact 4 contact), postseason follow-up outcome measures were obtained for each...

This study intended to examine effects of repetitive sub-concussive head impacts on ocular near point convergence (NPC). 20 healthy young adult soccer players were assigned either a heading or control group. Heading subjects completed 10 headers balls projected at speed 11.2 m/s. Control did not perform heading. Linear acceleration was measured with triaxial accelerometer. The NPC assessment performed pre-, 0 h post-, and 24 post-heading. During the participants seated visual target moved...

Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated impacts head, however, often display no observable behavioral deficits based on standard clinical tests, which may lack sensitivity. The study investigates effects of subconcussive from soccer heading with innovative measures vestibular function walking stability in a pre- 0–2 h, post- 24 h...

Importance Recurring exposure to head impacts in American football has garnered public and scientific attention, yet neurobiological associations adolescent players remain unclear. Objective To examine cortical structure neurophysiological characteristics players. Design, Setting, Participants This cohort study included control athletes (swimming, cross country, tennis) from 5 high school athletic programs, who were matched with age, sex (male), school. Neuroimaging assessments conducted May...

Objective Enhancing structural and functional integrity of mitochondria is an emerging therapeutic option against endothelial dysfunction. In this study, we sought to investigate the effect fluid shear stress on mitochondrial biogenesis respiratory function in cells (ECs) using vitro vivo complementary studies. Methods Results Human aortic- or umbilical vein-derived ECs were exposed laminar (20 dyne/cm2) for various durations a cone-and-plate apparatus. We observed significant increases...

The current study investigates whether repetitive subconcussive impacts cause changes in plasma S100β levels, and also tests the associations between frequency/magnitude of sustained. This prospective 22 Division-I collegiate football players included baseline pre-season practices (one helmet-only four full-gear). Blood samples were obtained assessed for levels at pre- to post-practices; symptom scores each time-point. An accelerometer-embedded mouthguard was employed measure number (hits),...

The purpose of the study was to examine an association repetitive subconcussive head impacts with changes in plasma neurofilament light (NF-L) levels following 10 bouts controlled soccer heading. In this randomized control trial, 37 healthy adult players were randomly assigned into either a heading (n = 19) or kicking-control group 18). executed headers balls projected at velocity 25 mph over min. Plasma samples obtained pre-heading baseline, 0 h, 2 and 24 h post-heading. followed same...

Introduction: Repetitive subconcussive head impacts in contact/collision sports such as US football are believed to contribute long-term brain changes and chronic symptoms. However, the lack of tools measure effects repeated subconcussion limits our understanding potential contributions neuropathological alterations including cellular damage.Methods: We examined using an accelerometer-embedded mouthguard on blood levels neurofilament light (NFL) chain 18 Division I college players. Plasma...

The purpose of the study was to test utility unique panel blood biomarkers as a means reflect one's recovery process after sport-related neurotrauma. We established that reacted positive with CD81 (extracellular vesicle marker) and various neuron- glia-specific antigens [e.g., neurofilament light polypeptide (NF-L), tau, synaptosome-associated protein 25 (SNAP25), glial fibrillary acidic protein, myelin basic protein]. first evaluated test-retest reliabilities brain-derived exosome markers,...

<h3>Importance</h3> Subconcussive head impacts have emerged as a complex public health concern. The oculomotor system is sensitive to brain trauma; however, neuro-ophthalmologic response subconcussive remains unclear. <h3>Objective</h3> To examine whether cause impairments in function measured by the King-Devick test (KDT) and near point of convergence. <h3>Design, Setting, Participants</h3> In this randomized clinical trial, adult soccer players were into either heading group or kicking...

Astrocyte-enriched marker, S100B, shows promise for gauging the severity of acute brain trauma, and understanding subconcussive effects will advance its utility in tracking real-time damage. The aim study was to investigate whether serum S100B elevations were associated with frequency magnitude head impacts adolescents. This prospective cohort 17 high-school football players consisted following 12 time points: pre-season baseline, 5 in-season pre-post games, post-season. A sensor-installed...

Importance Consequences of subconcussive head impacts have been recognized, yet most studies to date included small samples from a single site, used unimodal approach, and lacked repeated testing. Objective To examine time-course changes in clinical (near point convergence [NPC]) brain-injury blood biomarkers (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1], neurofilament light [NF-L]) adolescent football players test whether the outcomes were associated...

Soccer (football) is the most popular sport globally, with 265 million players across all ages and sexes. Repetitive subconcussive head impacts due to heading of soccer ball can pose threats healthy brain development aging. Omega-3 fatty acids, especially docosahexaenoic acid (DHA) eicosapentaenoic (EPA), may have neuroprotective effects, but it remains unclear what aspects neural health benefit from DHA+EPA when faced impacts. In a randomized placebo-controlled trial, 208 will complete...

<h3>Importance</h3> Repetitive subconcussive head impacts in sports have emerged as a complex public health issue. Most of these remain asymptomatic yet the potential to cause insidious neurological deficit if sustained repetitively. Near point convergence (NPC) values shown reflect subclinical neuronal damage; however, longitudinal pattern NPC changes association with remains unclear. <h3>Objectives</h3> To examine response recurring single high school football season through series...

While awareness and understanding of concussion have improved drastically, post-concussion management in academic settings is still at its infancy. The aim the study was to examine what extent influences on performance whether there would be a difference effects between high-school college students. This cross-sectional survey included students, who were 14 24 years old sustained sport-related within previous year. used modified chain-referral sampling method, by distributing questionnaire...

Traumatic brain injury (TBI) results in short and long-term disability neurodegeneration. Mild traumatic (mTBI) represents up to 85% of head injuries; diagnosis early management is based on computed tomography (CT) or in-hospital observation, which are time- cost- intensive. CT involves exposure potentially harmful ionizing radiation >90% the scans negative. Blood-brain barrier (BBB) damage suspected pathological event post-TBI contributing sequelae a reliable rapid point-of-care test screen...

Abstract Introduction Being choked/strangled during partnered sex is an emerging sexual behavior, particularly prevalent among young adult women. Using a multiparameter morphometric imaging approach, we aimed to characterize neuroanatomical differences between women (18–30 years old) who were exposed frequent choking and their naïve controls. Methods This cross‐sectional study consisted of two groups (choking [≥4 times in the past 30 days] vs. choking‐naïve group). Participants reported...

Athletes in contact sports sustain repetitive subconcussive head impacts a brief window, yet neurophysiological sequelae from subconcussion remain unclear. This prospective longitudinal study examined relationship between changes plasma Tau protein levels and impact kinematic data 23 Division I collegiate football players during series of pre-season practices. Plasma measures for S100β proteins, symptom scores, near point convergence were obtained at baseline pre-/post-practices. During each...

Cerebral malaria (CM) and severe malarial anemia (SMA) are associated with persistent neurocognitive impairment (NCI) among children in Africa. Identifying blood biomarkers of acute brain injury that future NCI could allow early interventions to prevent or reduce survivors malaria.To investigate whether acutely elevated tau levels after CM SMA.This prospective cohort study was conducted at Mulago National Referral Hospital Kampala, Uganda, from March 2008 October 2015. Children aged 1.5 12...