A5074594625- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Suicide and Self-Harm Studies
- Posttraumatic Stress Disorder Research
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Injury Epidemiology and Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Musculoskeletal pain and rehabilitation
- Genetics and Physical Performance
- Orthopedic Infections and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Personality Traits and Psychology
- Mitochondrial Function and Pathology
- Vagus Nerve Stimulation Research
Edward Hines, Jr. VA Hospital
2014-2024
University of Illinois Chicago
2020-2024
Northwestern University
2014-2023
Anesthesia Quality Institute
2023
Nevada State University
2022
Ripley Hospital
2022
Loyola University Chicago
2008-2020
Captain James A. Lovell Federal Health Care Center
2020
Franklin University
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2020
There is conflicting evidence regarding whether females are more adversely affected after concussion than males. Further, recent research suggests that hormonal contraceptive (HC) use may affect symptom severity and duration post-concussion. The objective of this study was to examine the effects sex HC on outcomes following among collegiate varsity athletes. We hypothesized would have longer length recovery (LOR), peak be associated with LOR in both males females. Among females, we non-HC...
Background. Sensory stimulation is often provided to persons incurring severe traumatic brain injury (TBI), but therapeutic effects are unclear. Objective. This preliminary study investigated neurobehavioral and neurophysiological related sensory on global functioning, arousal, awareness. Methods. A double-blind randomized placebo-controlled trial where 15 participants in states of disordered consciousness (DOC), an average 70 days after TBI, were either the Familiar Auditory Training (FAST)...
Traumatic brain injury (TBI) is a risk factor for suicide, but questions related to mechanisms remain unanswered. Impulsivity suicide and common sequela of TBI. The authors explored the relationships between TBI both suicidal ideation attempts whether impulsivity comorbid psychiatric diagnoses mediate these relationships.
Abstract Objective The aim of this study was to describe the association between mild traumatic brain injury (mTBI) and persisting postconcussive symptoms according symptom category, number, severity. Design design observational. Participants sample comprised veterans (≥18 years age) deployed in Operation Enduring Freedom Iraqi (OEF/OIF) conflicts who had not received any treatment for mTBI 30 days preceding enrollment. Methods Veterans were interviewed completed testing a single day....
The powerful, long-lasting association between the rewarding effects of a drug and contextual cues associated with administration can be studied using conditioned place preference (CPP). GABA(B) receptor agonist baclofen facilitates extinction morphine-induced CPP in mice. current study extended this work by determining if could enhance methamphetamine (Meth) CPP. was established six-day conditioning protocol wherein Meth-pairings were alternated saline-pairings. Rats subsequently...
Ionotropic AMPA receptors (AMPAR) and metabotropic glutamate group I subtype 5 (mGlu5) mediate neuronal behavioral effects of abused drugs. mGlu5 stimulation increases expression striatal-enriched tyrosine phosphatase isoform 61 (STEP61 ) which internalizes AMPARs. We determined the rat brain profile these proteins using two different classes drugs, opiates, stimulants. STEP61 levels, cellular distribution/expression AMPAR subunits (GluA1, GluA2) mGlu5, were evaluated via a protein...
Objective: Report pilot findings of neurobehavioral gains and network changes observed in persons with disordered consciousness (DoC) who received repetitive transcranial magnetic stimulation (rTMS) or amantadine (AMA), then rTMS+AMA. Participants: Four DoC 1 to 15 years after traumatic brain injury (TBI). Design: Alternate treatment-order, within-subject, baseline-controlled trial. Main Measures: For group individual analyses, predetermined thresholds, based on mixed linear-effects models...
Vocalizations of Xenopus laevis are generated by central pattern generators (CPGs). The advertisement call male X. is a complex biphasic motor rhythm consisting fast and slow trills (a train clicks). We found that the trill rate these calls sensitive to temperature this modification vocal rhythms originates in generators. In vivo rates increased linearly with an increase temperature. vitro similar linear relation between compound action potential frequency laryngeal nerve was when fictive...
Since there remains a need to examine the nature of neural effect and therapeutic efficacy/effectiveness sensory stimulation provided persons in states seriously impaired consciousness, passive intervention, referred as Familiar Auditory Sensory Training (FAST) protocol, was developed for examination an ongoing, double-blind, randomized clinical trial (RCT). The FAST protocol is described this article according preliminary framework, which synthesis knowledge regarding principles plasticity...
Objective: Research typically characterizes cannabis use by self-report of intake frequency. In an effort to better understand relationships between measures use, we evaluated if Δ-9-tetrahydrocannabinol (THC) and metabolite concentrations (biometrics) were associated with a calibrated timeline followback (TLFB) assessment use. Method: Participants 35 young adult male users who completed TLFB measure over the past 30 days, including time last The calibration required participants handling...
Objective: To present a heuristic model of symptom attribution and classification algorithm (SACA) for mild traumatic brain injury (mTBI). Setting: VA Polytrauma sites. Participants: 422 Veterans. Design: Cross-sectional. Main Measures: SACA, Comprehensive TBI Evaluation (CTBIE), Structured Diagnostic Interview, Minnesota Multiphasic Personality Inventory (MMPI-2-RF), Letter Memory Test, Validity-10. Results: SACA CTBIE diagnoses differ significantly ( P < .01). The CTBIE, compared with...
THE IDEA that noninvasive neuromodulation could be used for traumatic brain injury (TBI) rehabilitation originated, largely, from evidence transcranial magnetic stimulation (TMS) improves motor function and mood regulation.1–4 These seminal findings suggested to many researchers TMS treat functional impairments neurologic conditions,5 including TBI.6 While the idea of using therapeutic purposes evolved studies, growing interest in examining merits TBI is related, part, number devices (eg,...
Background. Despite a lack of clear evidence, multiple neurostimulants are commonly provided after severe brain injury (BI). The purpose this study is to determine if the number received during rehabilitation was associated with recovery full consciousness or improved neurobehavioral function BI. Method. Data from 115 participants were extracted observational database for exploratory, retrospective analysis. Univariate optimal data analysis conducted influenced classification four outcomes:...
Optimizing transcranial magnetic stimulation (TMS) treatments in traumatic brain injury (TBI) and co-occurring conditions may benefit from neuroimaging-based customization. Participants: Our total sample ( N = 97) included 58 individuals with TBI (49 mild, 8 moderate, 1 severe a state of disordered consciousness), which 24 had (depression 14 alcohol use disorder 10). Of those without TBI, 6 33 were healthy controls. our sample, 54 veterans 43 civilians. Design: Proof-of-concept study...
Alterations in receptor expression and distribution between cell surface cytoplasm are means by which psychostimulants regulate neurotransmission. Metabotropic glutamate group I, subtype 5 (mGluR5) GABA(B) receptors (GABA(B) R) critically involved the development of stimulant-induced behaviors, including conditioned place preference (CPP), an index drug-seeking. However, it is not known if psychostimulant-induced CPP alters trafficking these receptors. To fill this gap, study used...
Purpose: The evaluation and treatment for patients with prolonged periods of seriously impaired consciousness following traumatic brain injury (TBI), such as a vegetative or minimally conscious state, poses considerable challenges, particularly in the chronic phases recovery.Method: This blinded crossover study explored effects familiar auditory sensory training (FAST) compared sham stimulation patient seven years post severe TBI. Baseline data were collected over 4 weeks to account...
Early Life Stress (ELS) can profoundly influence an individual's genotype and phenotype. Effects of ELS manifest in the short-term, late life even subsequent generations. activate corticotrophin releasing factor (CRF); CRF influences drug seeking addiction. The aim this study was to examine effects endogenous elevated levels on addiction.Inducible forebrain over-expression mice (tetop-CRH x CaMKII-tTA) used for study. Morphine (10 mg/kg) administered every other day 10 days or with...