A5088617134- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Balance, Gait, and Falls Prevention
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Chronic Disease Management Strategies
- Systemic Lupus Erythematosus Research
- Neural dynamics and brain function
- Protein Tyrosine Phosphatases
- Nutritional Studies and Diet
- Neurobiology of Language and Bilingualism
- Cerebral Palsy and Movement Disorders
- Posttraumatic Stress Disorder Research
- Neuroscience and Music Perception
- Heart Rate Variability and Autonomic Control
- Muscle activation and electromyography studies
- Music Therapy and Health
- Traumatic Brain Injury Research
- Health Systems, Economic Evaluations, Quality of Life
VA Boston Healthcare System
2013-2024
Geriatric Research Education and Clinical Center
2012-2024
Harvard University
2011-2024
Brigham and Women's Hospital
2006-2020
Foundation for Physical Medicine and Rehabilitation
2020
National Institute on Aging
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2020
The University of Texas Health Science Center at San Antonio
2020
Boston University
2015-2020
University of Massachusetts Boston
2020
Abstract Cerebral white matter damage is not only a commonly reported consequence of healthy aging, but also associated with cognitive decline and dementia. The aetiology this unclear; however, individuals hypertension have greater burden signal abnormalities (WMSA) on MR imaging than those without hypertension. It therefore possible that elevated blood pressure (BP) impacts tissue structure which in turn has negative impact cognition. However, little information exists about whether...
Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) in military personnel is increasing dramatically following the OEF/OIF conflicts associated with alterations to structure. The present study examined relationship between PTSD cortical thickness, its possible modification by mTBI, a 104-subject veteran cohort ranging age from 20 62 years. For each participant, two T1-weighted scans were averaged create high-resolution images for calculation of regional thickness....
Background: Chronic misuse of alcohol results in widespread damage to the brain. Prior morphometric studies have examined cortical atrophy individuals with alcoholism; however, no previous alcohol‐associated using thickness measurements obtain regional mapping tissue loss across full surface. Methods: We compared measures from 31 abstinent a history prior abuse 34 healthy nonalcoholic control participants (total sample size = 65). Cortical surface models were created high‐resolution...
Background Evidence suggests that chronic misuse of alcohol may preferentially affect the integrity frontal white matter ( WM ) tracts, which can impact executive functions important to achieve and maintain abstinence. Methods Global regional microstructure was assessed using diffusion magnetic resonance measures fractional anisotropy FA for 31 abstinent alcoholics (ALC) with an average 25 years abuse approximately 5 sobriety 20 nonalcoholic control NC participants. Data processing conducted...
Abstract Prior research has demonstrated links among vascular health and the occurrence of stroke, mild cognitive decline, dementia in older adults. However, little is known about whether normal variation indicators may be related to changes neural tissue integrity. Even less how brain affected by cholesterol levels moderate risk range, leading up overt disease pathology. This study examined associations between serum lipid DTI white matter (WM) structural integrity a sample 125 generally...
White matter lesions, typically manifesting as regions of signal intensity abnormality (WMSA) on MRI, increase in frequency with age. However, the role this damage cognitive decline and disease is still not clear, lesion volume has only loosely been associated clinical status. Diffusion tensor imaging (DTI) used to examine quantitative microstructural integrity white matter, applications examination subtle changes tissue that appear visually normal conventional imaging. The primary goal...
Anosognosia is an unawareness or denial of deficits. While it has mainly been associated with damage to cortical brain regions, anosognosia also reported in patients subcortical disease. The present study investigated whether a feature Parkinson Forty-eight disease predominantly left- (N = 16) right-sided 32) motor symptoms who eventually underwent right left pallidotomies, and 48 individuals identified as caregivers completed questionnaires rating severity PD. There was no discrepancy...
Although hypertension is a major risk factor for cerebrovascular disease (CVD) and highly prevalent in African Americans, little known about how blood pressure (BP) affects brain-behavior relationships this population. In predominantly Caucasian populations, high BP associated with alterations frontal-subcortical white matter executive functioning aspects of cognition. We investigated associations among BP, brain structure, neuropsychological 52 middle-older-age Americans without diagnosed...
The aim of this study was to assess the impact burden and patterns multimorbidity on disability domains.
Abstract Improved understanding of the pattern white matter changes in early and prodromal Alzheimer's disease (AD) states such as mild cognitive impairment (MCI) is necessary to support earlier preclinical detection AD, debate remains whether MCI are secondary gray changes. We applied neuropsychologically based criteria a sample normally aging older adults; 32 participants met for 81 were classified normal control (NC) subjects. Whole-head high resolution T1 diffusion tensor imaging scans...
Metabolic syndrome (MetS) refers to a cluster of risk factors for cardiovascular disease, including obesity, hypertension, dyslipidemia, and hyperglycemia. While sizable prior literature has examined associations between individual quantitative measures cortical thickness (CT), only very limited research investigated such in MetS. Furthermore, the relative contributions these MetS-related effects on brain morphology have not yet been studied. The primary goal this investigation was examine...
Studies of cognitive functioning in patients with systemic lupus erythematosus (SLE) have found deficits even without other evidence neurologic involvement. The present study used scores on the 11 items Mini-Mental State Exam (MMSE) to classify impairment 93 SLE as suggestive "cortical" or "subcortical" dysfunction using a validated statistical algorithm. Ninety-five percent were categorized having deficits, and 5% deficits. When analysis was limited only those total MMSE ≤ 24, 81%...
Degenerative brain changes in Alzheimer’s disease may occur reverse order of normal development based on the retrogenesis model. This study tested whether evidence myelination was observed mild cognitive impairment (MCI) using a data-driven analytic approach life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions interest...
Metabolic syndrome (MetS), the presence of three or more cardiovascular risk factors, has been associated with subtle and diffuse neural compromise but not consistently cognitive dysfunction. Sustained attention is a fundamental operation that relies on multiple brain networks impaired in broad array neurologic conditions. We examined whether well-validated measure sustained would be sensitive to vascular risk, as compared standard neuropsychological measures executive functioning.We...
Abstract Introduction Metabolic syndrome (MetS) is a clustering of three or more cardiovascular risk factors (RF), including hypertension, obesity, high cholesterol, hyperglycemia. MetS and its component RFs are prevalent in older age, can be accompanied by alterations brain structure. Studies have shown altered functional connectivity (FC) samples with individual as well clinical populations that at higher to develop MetS. These studies indicated the default mode network (DMN) may...