A5083698601- Memory and Neural Mechanisms
- Memory Processes and Influences
- Identity, Memory, and Therapy
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Creativity in Education and Neuroscience
- Cognitive Functions and Memory
- Traumatic Brain Injury Research
- Mental Health Research Topics
- Psychology of Moral and Emotional Judgment
- Alzheimer's disease research and treatments
- Decision-Making and Behavioral Economics
- Child and Adolescent Psychosocial and Emotional Development
- Neurobiology of Language and Bilingualism
- Child and Animal Learning Development
- Neuroscience and Music Perception
- Neuroscience, Education and Cognitive Function
- Cognitive Abilities and Testing
- Media Influence and Health
- Health, Environment, Cognitive Aging
- Psychological and Temporal Perspectives Research
- Neuroendocrine regulation and behavior
- Posttraumatic Stress Disorder Research
University of British Columbia
2018-2025
Vancouver Coastal Health
2024
University of British Columbia Hospital
2023
New York Academy of Sciences
2023
John Wiley & Sons (Germany)
2023
Moss Landing Marine Laboratories
2023
Hudson Institute
2023
VA Boston Healthcare System
2014-2021
University of Toronto
2010-2019
Boston University
2014-2019
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
In the present study, we investigated effect of medial temporal lobe (MTL) damage on human decision making in context reward-based intertemporal choice. During choice, humans typically devalue (or discount) a future reward to account for its delayed arrival (e.g., preferring $30 now over $42 2 months), but this is attenuated when participants engage episodic thinking, i.e., project themselves into imagine specific event. We hypothesized that attenuation would be selectively impaired amnesic...
Choosing between two items involves deliberation and comparison of the features each item its value. Such decisions take more time when choosing options similar value, possibly because these require evidence, but mechanisms involved are not clear. We propose that hippocampus supports about given well-known role in prospection relational cognition. assessed experiments. First, using fMRI healthy participants, we found BOLD activity increased as a function time. Second, patients with...
Recollection of previously experienced events is a key element human memory that entails recovery spatial, perceptual, and mental state details. While deficits in this capacity association with brain disease have serious functional consequences, little known about individual differences autobiographical (AM) healthy individuals. Recently, adults highly superior capacities been identified (e.g., LePort, A.K., Mattfeld, A.T., Dickinson-Anson, H., Fallon, J.H., Stark, C.E., Kruggel, F.,...
People vary in how they remember the past: some recall richly detailed episodes; others more readily access semantic features of events. The neural correlates such trait-like differences episodic and remembering are unknown. We found that self-reported individual one recalls past were related to predictable intrinsic connectivity patterns medial temporal lobe (MTL) memory system. A pattern MTL posterior brain regions supporting visual-perceptual processing (occipital/parietal cortices) was...
Abstract Background While it is known that exposure to traffic-related air pollution causes an enormous global toll on human health, neurobiological underpinnings therein remain elusive. The study addresses this gap in knowledge. Methods We performed the first controlled using functional MRI with efficient order-randomized double-blind crossover of diesel exhaust (DE) and control (filtered air; FA) 25 healthy adults (14 males, 11 females; 19–49 years old; no withdrawals). Analyses were...
ABSTRACT There is great interest in the cognitive consequences of hippocampal volume loss developmental amnesia (DA). In many DA cases, occurs before hippocampus fully developed, and yet little known about locus, extent, distribution damage these cases. We used high‐resolution MRI to manually segment medial temporal lobe (MTL) subregions H.C., an adult with DA, a group sex‐, age‐ education‐matched control participants ( n = 10). The was defined divided into anterior (head) posterior (body...
We investigated autobiographical memory in a group of passengers onboard trans-Atlantic flight that nearly ditched at sea. The consistency traumatic exposure across passengers, some whom developed post-traumatic stress disorder (PTSD), provided unique opportunity to assess verified for life-threatening trauma. Using the Autobiographical Interview, which separates episodic from non-episodic details, and healthy controls (HCs) recalled three events: airline disaster (or highly negative event...
Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim develop a harmonized protocol based expert consensus histological evidence. Methods Our international working group, funded by EU Joint Programme–Neurodegenerative Disease Research (JPND), is toward production reliable, validated, regions. The group uses novel postmortem...
The <i>KIBRA</i> gene has been associated with episodic memory in several recent reports; carriers of the T-allele show enhanced performance relative to noncarriers. Gene expression studies human and rodent species high levels hippocampus, particularly subfields. goal present study was determine whether C→T polymorphism is also volume differences hippocampus specific subfields are differentially affected by genotype. High-resolution magnetic resonance imaging (T2-weighted, voxel size = 0.4 ×...
Previous research has shown that the medial temporal lobes (MTL) are more strongly engaged when individuals think about future than present, leading to suggestion projection drives MTL engagement. However, thinking tasks often involve scene processing, leaving open alternative possibility scene-construction demands, rather projection, responsible for differences observed in prior work. This study explores this account. Using functional magnetic resonance imaging, we directly contrasted...
Striking individual differences exist in the human capacity to recollect past events, yet, little is known about neural correlates of such differences. Studies investigating hippocampal volume relation laboratory measures episodic memory young adults suggest that whole unrelated (or even negatively associated) with memory. However, anatomical and functional specialization across subregions suggests may be linked particular subregions, as opposed volume. Given DG/CA2/3 circuitry thought...
Emotionally enhanced memory and susceptibility to intrusive memories after trauma have been linked a deletion variant (i.e., form of gene in which certain amino acids are missing) ADRA2B, the encoding subtype B α 2 -adrenergic receptor, influences norepinephrine activity. We examined 207 participants whether variations this responsible for individual differences affective on initial that alter perceptual awareness. attentional blink, an impairment during rapid serial visual presentation,...
We investigated the neural correlates of remote traumatic reexperiencing in survivors a life-threatening incident: near crash Air Transat (AT) Flight 236. Survivors' brain activity was monitored during video-cued recollection AT disaster, September 11th, 2001 (9/11), and comparatively non-emotional (neutral) event. Passengers showed robust memory enhancement effect for incident relative to 9/11 neutral events. This associated with activation amygdala, medial temporal lobe, anterior posterior...
Our memories can differ in quality from one event to the next, and emotion is important explanatory factor. Still, manner which impacts episodic memory complex: Whereas enhances some aspects of memory—particularly central aspects—it dampens for peripheral/contextual information. Extending previous work, we examined effects on often overlooked aspect memory, namely, temporal context. We tested whether would impair when an occurred. Participants ( N = 116 adults) watched videos wherein...