A5037719006- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Medical Image Segmentation Techniques
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Cell Image Analysis Techniques
- Machine Learning in Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Brain Tumor Detection and Classification
- Mitochondrial Function and Pathology
- Infant Development and Preterm Care
- Vestibular and auditory disorders
- Neurological diseases and metabolism
- Schizophrenia research and treatment
- Domain Adaptation and Few-Shot Learning
Hospital for Sick Children
2020
Centre for Addiction and Mental Health
2013-2017
McGill University
2015-2017
University of Toronto
2015-2017
Douglas Mental Health University Institute
2015-2017
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
Newer approaches to characterizing hippocampal morphology can provide novel insights regarding cognitive function across the lifespan.We comprehensively assessed relationships among age, morphology, and hippocampal-dependent in 137 healthy individuals adult lifespan (18-86 years of age).They underwent MRI, assessments genotyping for Apolipoprotein E status.We measured subfield volumes using a new multiatlas segmentation tool (MAGeT-Brain) vertex-wise (inward outward displacements) global...
The hippocampus, a medial temporal lobe structure central to learning and memory, is particularly vulnerable in preterm-born neonates. To date, segmentation of the hippocampus for neonates has not yet been performed early-in-life (shortly after birth when clinically stable). present study focuses on development validation an automatic protocol that based MAGeT-Brain (Multiple Automatically Generated Templates) algorithm delineate hippocampi preterm their brain MRIs acquired at only...
Recent advances in multi-atlas based algorithms address many of the previous limitations model-based and probabilistic segmentation methods. However, at label fusion stage, a majority focus primarily on optimizing weight-maps associated with atlas library theoretical objective function that approximates error. In contrast, we propose novel method - Autocorrecting Walks over Localized Markov Random Fields (AWoL-MRF) aims mimicking sequential process manual segmentation, which is gold-standard...
The human hippocampus has been broadly studied in the context of memory and normal brain function its role different neuropsychiatric disorders heavily studied. While many imaging studies treat as a single unitary neuroanatomical structure, it is, fact, composed several subfields that have complex three-dimensional geometry. As such, is known these perform specialized functions are differentially affected through course disease states. Magnetic resonance (MR) can be used powerful tool to...
An impediment to the development of effective therapies for neurodegenerative disease is that available animal models do not reproduce important clinical features such as adult-onset and stereotypical patterns progression. Using in vivo magnetic resonance imaging behavioral testing study male female decrepit mice, we found a neuroanatomical pattern progression lesion along limbic system network an associated memory impairment. structural variant analysis, identified intronic mutation...
The human hippocampus has been broadly studied in the context of memory and normal brain function its role different neuropsychiatric disorders heavily studied. While many imaging studies treat as a single unitary neuroanatomical structure, it is, fact, composed several subfields that have complex three-dimensional geometry. As such, is known these perform specialized functions are differentially affected through course disease states. Magnetic resonance (MR) can be used powerful tool to...