A5045847024- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Memory Processes and Influences
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Child and Animal Learning Development
- Cognitive Functions and Memory
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Neurobiology of Language and Bilingualism
- Neurogenesis and neuroplasticity mechanisms
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Action Observation and Synchronization
- Attention Deficit Hyperactivity Disorder
- Birth, Development, and Health
- Neuroscience and Music Perception
- Biochemical Analysis and Sensing Techniques
- Advanced MRI Techniques and Applications
- Language and cultural evolution
- Identity, Memory, and Therapy
- Face Recognition and Perception
Wayne State University
2016-2025
The University of Texas at Dallas
2024-2025
University of Dallas
2024
Woodward (United States)
2021-2022
Weizmann Institute of Science
1998-2020
Michigan United
2018
Children's Hospital of Michigan
2015
Detroit Medical Center
2015
Massachusetts Institute of Technology
2007-2013
McGovern Institute for Brain Research
2011-2013
Abstract We examined the normal development of intrinsic functional connectivity default network (brain regions typically deactivated for attention-demanding tasks) as measured by resting-state fMRI in children, adolescents, and young adults ages 8–24 years. investigated both positive negative correlations employed analysis methods that allowed valid interpretation also minimized influence motion artifacts are often confounds developmental neuroimaging. As age increased, there were robust...
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1-CA4), dentate gyrus (DG), and subiculum. few in vivo studies human hippocampal subfields suggest that extent age differences volume varies across during healthy childhood development aging. However, associations between subfield volumes entire lifespan are unknown. Here, we used a high-resolution imaging technique manually measured entorhinal cortex sample (N = 202), ages 8-82 yrs. magnitude varied among...
Neuroanatomical and psychological evidence suggests prolonged maturation of declarative memory systems in the human brain from childhood into young adulthood. Here, we examine functional development during successful retrieval scenes children, adolescents, adults ages 8-21 via magnetic resonance imaging. Recognition improved with age, specifically for accurate identification studied (hits). Successful (correct old-new decisions vs unstudied scenes) was associated activations frontal,...
Abstract An individual's socioeconomic status ( SES ) is often viewed as a proxy for host of environmental influences. disparities have been linked to variance in brain structures particularly the hippocampus, neural substrate learning and memory. However, it unclear whether association between hippocampal volume similar children adults. We investigated relationship group n = 31, age 8–12 years) young adults 32, 18–25 years). was assessed with four indicators that loaded on single factor,...
Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim develop a harmonized protocol based expert consensus histological evidence. Methods Our international working group, funded by EU Joint Programme–Neurodegenerative Disease Research (JPND), is toward production reliable, validated, regions. The group uses novel postmortem...
Neuroimaging evidence suggests that the development of hippocampus, a brain structure critical for memory function, contributes to improvements episodic between middle childhood adulthood. However, investigations on age differences in hippocampal activation and functional connectivity their contributions have yielded mixed results. Given known structural heterogeneity along long axis we investigated subregions with cross-sectional sample 96 participants ages 8-25 years. We found anterior...
The development of the brain, particularly protracted maturation prefrontal cortex (PFC), supports episodic memory. Yet how different regions PFC functionally mature to support age-related increases in memory performance remains unclear. We investigated contribution subsequent (SM) encoded visual scenes children, adolescents, and young adults (n = 83). identified distinct patterns activations supporting SM: lateral showed positive SM effects, whereas superior medial negative effects. Both...
Although a growing body of literature suggests that cognitive control processes are involved in deception, much about the neural correlates lying remains unknown. In this study, we tested whether brain activation associated with as measured by functional magnetic resonance imaging (fMRI), can be detected either preparation for or during execution lie, and they depend on content lie. We scanned participants while lied told truth their personal experiences (episodic memories) beliefs. Regions...
Summary Declarative memory depends on the coordination of local processing, indexed by high-frequency broadband (HFB) activity, with global network organization, theta oscillations. However, and HFB exhibit asynchronous timing, raising question how results processing are communicated throughout network. Using intracranial EEG in patients performing a recognition task, we examined this across medial temporal lobe (MTL) prefrontal cortex (PFC). peak activity was earlier MTL than PFC. Anchoring...
Episodic memory relies on the formation and retrieval of content-specific traces. In addition to their veridical reactivation, previous studies have indicated that traces may undergo substantial transformations. However, exact time course regional distribution reinstatement transformation during recognition remained unclear. We applied representational similarity analysis human intracranial electroencephalography track spatiotemporal dynamics underlying Specifically, we examined how...
The default mode network (DMN) refers to regional brain activity that is greater during rest periods than attention-demanding tasks and many studies have reported DMN alterations in patient populations. It has also been shown the suppressed by scanner background noise (SBN), which produced functional magnetic resonance imaging (fMRI). However, it unclear whether different approaches "rest" noisy MR environment can alter constitute a confound investigating particular populations (e.g.,...
Previous brain imaging studies have identified three regions that selectively respond to visual scenes, the parahippocampal place area (PPA), occipital (OPA), and retrosplenial cortex (RSC). There is growing evidence these scene-sensitive process different types of scene information may developmental timelines in supporting perception. How support memory functions during child development largely unknown. We investigated PPA, OPA RSC activations associated with episodic formation childhood...
Hippocampal subfields differentially develop and age, they vary in vulnerability to neurodegenerative diseases. Innovation high-resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial differences segmentation protocols impede comparisons of results across laboratories. The Subfields Group (HSG) is an international organization seeking address this issue by developing a histologically-valid, reliable, freely available protocol for T2-weighted 3...