A5091674486- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Cannabis and Cannabinoid Research
- Neurological Disease Mechanisms and Treatments
- Cognitive Abilities and Testing
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Nutritional Studies and Diet
- Attention Deficit Hyperactivity Disorder
- Advanced MRI Techniques and Applications
- Genetic Associations and Epidemiology
- Hemispheric Asymmetry in Neuroscience
- Nutrition, Genetics, and Disease
- Folate and B Vitamins Research
- Infant Nutrition and Health
- Autism Spectrum Disorder Research
- Metabolomics and Mass Spectrometry Studies
- Machine Learning in Bioinformatics
- Neural dynamics and brain function
University of Oregon
2018-2019
University of California, Los Angeles
2009-2018
UCLA Health
2010-2018
Center for Neurosciences
2018
Neurobehavioral Systems
2009-2017
Resnick Sustainability Institute
2011
Technische Universität Dresden
2010
University of California, Davis
2010
German Center for Neurodegenerative Diseases
2010
Brain Mapping Foundation
2002-2006
Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions brain persons with mild cognitive impairment who at risk for disease. Noninvasive methods to detect these abnormal proteins potentially useful developing surrogate markers drug discovery diagnostics.We enrolled 83 volunteers self-reported memory problems had undergone neurologic psychiatric evaluation positron-emission tomography (PET). On...
Old age and possession of the APOE -4 allele are two main risk factors for developing later onset Alzheimer's Disease (AD). Carriers have known differences in intrinsic functional brain network activity across life span. These individuals also demonstrate specific regional gray white matter gross structure. However, relationship these variations to whole structural connectivity remains unclear. We performed diffusion tensor imaging (DTI), T1 imaging, cognitive testing on aging noncarriers (...
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated total hippocampal volume, a heavily studied memory-critical region within MTL. However, research on associations between sedentary behavior and MTL subregion integrity limited. Here we explore thickness its subregions (namely CA1, CA23DG, fusiform gyrus, subiculum, parahippocampal, perirhinal entorhinal cortex,), physical activity, behavior. We assessed...
To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change.Two-year, longitudinal follow-up study.A university research institute.Volunteer sample of 43 middle-aged older persons (median age, 64 years), including 21 mild impairment (MCI) 22 normal aging.Longitudinal [(18)F]FDDNP positron emission tomography (PET)...
Abstract Variants at 21 genetic loci have been associated with an increased risk for Alzheimer’s disease (AD). An important unresolved question is whether multiple factors can be combined to increase the power detect changes in neuroimaging biomarkers AD. We acquired high-resolution structural images of hippocampus 66 healthy, older human subjects. For 45 these subjects, longitudinal 2-year follow-up data were also available. calculated additive AD score each participant and contrasted this...
The current study examined the independent and combined effects of HIV marijuana (MJ) use (no use, light moderate-to-heavy use) on neurocognitive functioning among a convenience sample HIV-positive (HIV+) HIV-negative (HIV–) individuals recruited from community care clinics advertisements in Greater Los Angeles area. MJ users consisted who reported regular for at least 12 months, with last within past month. Participants included 89 HIV+ (n = 55) HIV– 34) were grouped into non-users, users,...
Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim develop a harmonized protocol based expert consensus histological evidence. Methods Our international working group, funded by EU Joint Programme–Neurodegenerative Disease Research (JPND), is toward production reliable, validated, regions. The group uses novel postmortem...
Structural brain changes appear years before the onset of Alzheimer's disease, leading cause dementia late in life. Determining risk factors for such presymptomatic may assist identifying candidates future prevention treatment trials. In addition to e4 allele apolipoprotein E gene (APOE-4), major known genetic factor, a family history disease also increases develop reflecting yet unidentified and, perhaps, nongenetic risks. The authors investigated influence APOE-4 genotype and risks on...
Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer disease that accumulate in the brains people without dementia years before they develop dementia. Positron emission tomography (PET) scans after intravenous injections 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), which binds to vitro, demonstrate increased cerebral binding patients with compared cognitively intact controls. Here we investigated...
The hippocampal complex is affected early in Alzheimer's disease (AD). Increasingly, altered functional connectivity of the hippocampus recognized as an important feature preclinical AD. Carriers APOEɛ4 allele are at increased risk for AD, which could lead to even healthy older adults. To test this hypothesis, we used a paired-associates memory task examine differences task-dependent anterior and posterior nondemented carriers (n = 34, 18F) noncarriers 46, 31F). We examined portions...
Background and Aims: Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful developing adolescent brain compared with adult-onset usage. However, long-term effects heavy, on structure cognitive performance late-life remain unknown. A critical region is hippocampus (HC), where there a striking intersection between...
Abstract Hippocampal subfields differentially develop and age, they vary in vulnerability to neurodegenerative diseases. Innovation high-resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial differences segmentation protocols impede comparisons of results across laboratories. The Subfields Group (HSG) is an international organization seeking address this issue by developing a histologically-valid, reliable, freely available protocol for T 2...