A5001741472- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Cerebral Palsy and Movement Disorders
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Balance, Gait, and Falls Prevention
- COVID-19 and Mental Health
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Posttraumatic Stress Disorder Research
- Neural and Behavioral Psychology Studies
- Memory Processes and Influences
- Ultrasound Imaging and Elastography
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological and metabolic disorders
- Iron Metabolism and Disorders
- Effects of Vibration on Health
- Cognitive Abilities and Testing
- Aging and Gerontology Research
- Spatial Cognition and Navigation
Wayne State University
2016-2025
University of Illinois Urbana-Champaign
2016-2024
Neurosciences Institute
2018-2021
Woodward (United States)
2021
Dougherty Foundation
2020
Rubin
2020
D.F. Chebotarev Institute of Gerontology
2012-2015
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1-CA4), dentate gyrus (DG), and subiculum. few in vivo studies human hippocampal subfields suggest that extent age differences volume varies across during healthy childhood development aging. However, associations between subfield volumes entire lifespan are unknown. Here, we used a high-resolution imaging technique manually measured entorhinal cortex sample (N = 202), ages 8-82 yrs. magnitude varied among...
The accumulation of non-heme iron in the brain has been proposed as a harbinger neural and cognitive decline aging neurodegenerative disease, but support for this proposal drawn from cross-sectional studies, which do not provide valid estimates change. Here, we present longitudinal evidence subcortical healthy human adults (age 19–77 at baseline). We used R2* relaxometry to estimate regional content twice within 2 year period, measured volumes striatum hippocampus by manual segmentation,...
The positive relationship between hippocampal structure, aerobic fitness, and memory performance is often observed among children older adults; but evidence of this young adults, for whom the hippocampus neither developing nor atrophying, less consistent. Studies have typically relied on volumetry (a gross proxy tissue composition) to assess individual differences in structure. While volume not specific microstructural characteristics, integrity may exist even healthy adults when volumetric...
The goal of this study was to examine the relationships between 2 age-sensitive indices brain integrity—volume and iron concentration—and associated age differences in memory performance. In 113 healthy adults (age 19–83 years), we measured volume estimated concentration hippocampus (HC), caudate nucleus (Cd), primary visual cortex (VC) vivo with T2* relaxation times, assessed performance multiple tests. We applied structural equation modeling evaluate contribution individual integrity, T2*,...
Abstract The term “first responders” refers to a range of professional occupations, including police officers, fire fighters, search and rescue personnel, ambulance military personnel. Research by the present authors has developed empirical models first responder coping, identifying 2 coping pathways with differential outcomes: approach avoidance coping. investigation considers officers as unique group measures extent which differ from other responders in behaviours following trauma, based...
Abstract An individual's socioeconomic status ( SES ) is often viewed as a proxy for host of environmental influences. disparities have been linked to variance in brain structures particularly the hippocampus, neural substrate learning and memory. However, it unclear whether association between hippocampal volume similar children adults. We investigated relationship group n = 31, age 8–12 years) young adults 32, 18–25 years). was assessed with four indicators that loaded on single factor,...
Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim develop a harmonized protocol based expert consensus histological evidence. Methods Our international working group, funded by EU Joint Programme–Neurodegenerative Disease Research (JPND), is toward production reliable, validated, regions. The group uses novel postmortem...
Neuroimaging evidence suggests that the development of hippocampus, a brain structure critical for memory function, contributes to improvements episodic between middle childhood adulthood. However, investigations on age differences in hippocampal activation and functional connectivity their contributions have yielded mixed results. Given known structural heterogeneity along long axis we investigated subregions with cross-sectional sample 96 participants ages 8-25 years. We found anterior...
Purpose Individuals with multiple sclerosis (MS) experience fear of falling (FOF), which is associated negative health and quality-of-life consequences. Prior research has used FOF concern about (CAF) interchangeably, but persons MS report that CAF represent separate constructs lie on a continuum. Unfortunately, no scale exists to understand the differences between FOF. Therefore, we developed novel questionnaire, Concern Fear Falling Evaluation (CAFFE), in respondents rank their continuum...
Advanced age and vascular risk negatively affect episodic memory. The hippocampus (HC) is a complex structure, little known about the roles of different HC regions in age-related memory declines. Using data from an ongoing longitudinal study, we investigated whether functions are related to volumes specific subregions (CA1-2, CA3-4/dentate gyrus, subiculum). Furthermore, inquired if arterial hypertension, common factor, modifies differences regional volumes, concurrent performance,...
Introduction: Despite the prevalence of and negative health consequences associated with perceived loneliness in older adults, few studies have examined interactions among behavioral, psychosocial neural mechanisms. Research suggests that physical activity improvements social support stress are related to reductions loneliness. Yet, influence brain structure on these changes is unknown. The present study whether change regional volume mediated effects after an exercise intervention. We also...
Background. Police officer response in a critical incident is often life-or-death scenario for the officer, suspect, and public. Efficient accurate decisions are necessary to ensure safety of all involved. Under these conditions, it important understand effects physiological arousal acute stress on police performance dangerous incidents. Prior research suggests that following stressor differentially affects performance—communication may be impaired, whereas well-rehearsed, tactical behaviors...
Age-related memory impairments have been linked to differences in structural brain parameters, including the integrity of hippocampus (HC) and its distinct hippocampal subfields (HCsf). Imaging methods sensitive underlying tissue microstructure are valuable characterizing age-related HCsf changes that may relate cognitive function. Magnetic resonance elastography (MRE) is a noninvasive MRI technique can quantify viscoelasticity provide additional information about aging effects on health....
Hippocampal subfields (HCsf) are brain regions important for memory function that vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer's disease. Studies in aMCI patients assess HCsf tissue integrity using measures volume, has little specificity microstructure and pathology. We use magnetic resonance elastography (MRE) examine the viscoelastic mechanical properties tissue, related structural integrity, sensitively detect...