A5086065096- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Systemic Lupus Erythematosus Research
- Diabetes Management and Research
- Vaccine Coverage and Hesitancy
- Blood Pressure and Hypertension Studies
- Cancer Risks and Factors
- Healthcare Policy and Management
- Global Health Workforce Issues
- Cell Adhesion Molecules Research
- Pancreatic function and diabetes
- Ophthalmology and Visual Impairment Studies
- Childhood Cancer Survivors' Quality of Life
- Diversity and Career in Medicine
- Innovations in Medical Education
- Gestational Diabetes Research and Management
- Obesity and Health Practices
Sheba Medical Center
2013-2025
Reichman University
2024-2025
Tel Aviv University
2015-2024
Herzliya Medical Center
2024
Tzu Chi University
2024
Schneider Children's Medical Center
2023
Vall d'Hebron Hospital Universitari
2022
Israel Ministry of Health
2013-2020
Meir Medical Center
2018
Amsterdam UMC Location University of Amsterdam
2018
In light of the worldwide increase in childhood obesity, we examined association between body-mass index (BMI) late adolescence and death from cardiovascular causes adulthood.
The association of body-mass index (BMI) from adolescence to adulthood with obesity-related diseases in young adults has not been completely delineated.
In December, 2020, the Israeli Government approved BNT162b2 COVID-19 vaccine and initiated a national immunisation campaign prioritising health-care workers (HCWs), as in other countries.1Hassan-Smith Z Hanif W Khunti K Who should be prioritised for vaccines?.Lancet. 2020; 396: 1732-1733Summary Full Text PDF PubMed Scopus (32) Google Scholar This coincided with third wave of COVID-19, peaking at 10 116 daily new cases by mid-January, 2021. The Sheba Medical Centre, Israel's largest hospital...
Naturally occurring CD4+ CD25+ regulatory T cells (Tregs) exert suppressive effects on effector CD4 and downregulate experimental autoimmune disorders. We investigated the importance potential role of Tregs in murine atherogenesis.Tregs were comparatively between aged young apolipoprotein E-knockout (ApoE-KO) mice age-matched C57BL/6 littermates. The effect oxidized LDL (oxLDL) was tested functional properties from ApoE-KO mice. Tregs, CD25- cells, saline infused into to study their...
Background Physicians play a crucial frontline role in the COVID-19 pandemic, which may involve high levels of anxiety. We aimed to investigate association between pandemic-related stress factors (PRSF) and anxiety evaluate potential effect resilience on among physicians. Methods A self-report digital survey was completed by 1106 Israeli physicians (564 males 542 females) during outbreak. Anxiety measured 8-item version Patient-Reported Outcomes Measurement Information System. Resilience...
BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing vaccine rollout, and achievement of herd immunity depend on SARS-CoV-2 transmission reduction. The vaccine's effect infectivity is thus a critical priority.
The BNT162b2 two-dose vaccine (BioNTech/Pfizer) has high effectiveness that wanes within several months. third dose is effective in mounting a significant immune response, but its durability unknown.To compare antibody waning after second and doses estimate the association of kinetics with susceptibility to infection Omicron variant SARS-CoV-2.In prospective longitudinal cohort study tertiary medical center Israel, health care workers who received were followed up monthly for IgG...
Background —β 2 -Glycoprotein I (β2GPI) is a major antigenic target of antiphospholipid antibodies, which possesses natural anticoagulant properties. The aim the present study was to determine its presence and localization within human atherosclerotic plaques association with endothelial cells monocyte macrophages in vitro. Methods Results —Human lesions were obtained after carotid endarterectomies studied immunohistochemically anti-β2GPI as well antibodies CD4/CD8, macrophages, adhesion...
Background —Immunization with β 2 -glycoprotein I (β2GPI), the probable target of autoimmune anticardiolipin antibodies, results in experimental antiphospholipid syndrome different mouse strains. The present study was undertaken to evaluate effect β2GPI immunization on progression atherosclerosis. Methods and Results —In first experiment, 3 groups LDL receptor–deficient (LDL-RD) mice (n=15 per group) were immunized either or ovalbumin not fed a chow diet for 12 weeks. In second LDL-RD (n=10...
Recent data suggest that the immune system is involved in atherogenesis. Thus, interest has been raised as to possible antigens could serve initiators of reaction. In current work, we studied effects immunization with recombinant heat shock protein-65 (HSP-65) and HSP-65-rich Mycobacterium tuberculosis (MT) on early atherogenesis C57BL/6J mice fed either a normal chow diet or high-cholesterol (HCD). A rapid, cellular response HSP-65 was evident immunized MT but not animals phosphate-buffered...
Recent clinical trials use cell therapy with bone marrow (BM) cells or endothelial progenitor (EPCs) for ischemic syndromes. We explored the effect of BM cell- spleen cell-derived EPC transfer on plaque size and stability markers in apolipoprotein E knockout (apoE KO) mouse model.ApoE KO mice aged 10 weeks served as recipients. Labeled EPCs from age-matched apoE were injected intravenously to 2 groups recipient each. Additional controls receiving saline. Both protocols repeated 3 times at...
Background Human 15-lipoxygenase (LO) and its murine analogue 12/15-LO are capable of directly oxidizing esterified fatty acids in lipoproteins phospholipids. Because these oxidized products possess atherogenic properties, it was suggested that LOs may be involved enhancing atherogenesis. Previous vivo tests the role atherogenesis animal models, however, have yielded conflicting results. Methods Results Aiming to study atherogenesis, we crossed LDL-receptor–deficient mice (LDL-R −/− ) with...
The long-term risk associated with childhood kidney disease that had not progressed to chronic in is unclear. We aimed estimate the of future end-stage renal (ESRD) among adolescents who normal function and a history disease.We conducted nationwide, population-based, historical cohort study 1,521,501 Israeli were examined before compulsory military service 1967 through 1997; data linked ESRD registry. Kidney diseases included congenital anomalies urinary tract, pyelonephritis, glomerular...
Although prehypertension at adolescence is accepted to indicate increased future risk of hypertension, large-scale/long follow-up studies are required better understand how adolescent blood pressure (BP) tracks into young adulthood. We studied 23 191 male and 3789 female adolescents from the Metabolic Lifestyle Nutrition Assessment in Young Adults cohort (mean age: 17.4 years) with BP <140/90 mm Hg enrollment or categorized by current criteria for pediatric body mass index (BMI) values....
OBJECTIVE Association between white blood cell (WBC) count and diabetes risk has been recently suggested. We assessed whether WBC is an independent factor for incidence among young healthy adults. RESEARCH DESIGN AND METHODS was measured in 24,897 (mean age 30.8 ± 5.36 years), normoglycemic men with range of 3,000 to 12,000 cells/mm3. Participants were periodically screened during a mean follow-up 7.5 years. RESULTS During 185,354 person-years follow-up, diagnosed 447 subjects. A...
OBJECTIVE Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D early adulthood. RESEARCH DESIGN AND METHODS A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.4 years) during 1996–2016. Data were linked to Israeli National Diabetes Registry. Weight and height measured entry. Cox proportional models applied. RESULTS During 15,810,751 person-years, 2,177 people (69% men)...
OBJECTIVE To determine diabetes incidence over time among obese young adults without metabolic risk factors. RESEARCH DESIGN AND METHODS Incident during a median follow-up of 6.1 years was assessed 33,939 men (mean age 30.9 ± 5.2 years) the Metabolic, Lifestyle and Nutrition Assessment in Young Adults cohort who were stratified for BMI number abnormalities (based on Adult Treatment Panel-III). Metabolically healthy (MH) obesity defined as ≥30 kg/m2 presence normoglycemia, normal blood...
The repeated waves of the COVID-19 pandemic have highlighted necessity to optimize vaccine responses in immunocompromised populations. We investigated safety and immunogenicity a third, booster, dose Pfizer BNT162b2 heart transplant (HT) patients.