To compare the growth and accumulation of protein, fat, carbohydrate in formula-fed premature infant fetus a similar postconceptional age, we performed 22 metabolic studies 13 infants very low birth weight (1155 +/- 39 g [mean S.E.]). Measurements combining nutritional balance indirect calorimetry demonstrated deposition rates protein fat. We found that formula-fed, very-low-birth-weight who gained comparably to retained same amount (1.92 0.1 per kilogram body day) but accumulated fat at...

Late-onset sepsis (LOS) is an important cause of mortality among very low birth weight (VLBW) infants, and deaths occurring within 3 days after the onset can probably be ascribed to sepsis. We examined association due specific pathogens with risk for early LOS, adjusted perinatal neonatal factors.From 1995 through 2001, information about 10,215 infants was gathered deposited in Israel National VLBW Infant Database. The study population composed 2644 which each had >or=1 events LOS (totalling...

To assess whether overweight children and adolescents are at an increased risk for vitamin B(12) deficiency.Prospective descriptive study.Two pediatric endocrine centers in Israel.Three hundred ninety-two were divided into 2 groups as follows: the normal-weight group had body mass indexes, calculated weight kilograms by height meters squared, under 95th percentile (<1.645 standard deviation scores; n = 228); obese indexes equal to or above (>/=1.645 164).We measured concentrations. Low serum...

To assess whether the postnatal growth of preterm very-low-birthweight (VLBW) infants, as determined by measures failure (PNGF), improved during period 1995-2010 and to evaluate gestational age (GA) intrauterine groups.The study was based on Israel national VLBW infant database comprised 13 531 infants 24-32 weeks' GA, discharged at a postmenstrual ≤40 weeks. Z-scores were for weight birth discharge. Severe mild PNGF defined decrease >2 1-2 z-scores, respectively. Three time periods...

To assess the association between obesity and primary headaches in children adolescents.In a prospective study, short-questionnaire version based on existing International Headache Society diagnostic criteria was administered. Two hundred seventy-three adolescents (61% females) aged 9-17 years were assessed. One sixteen (42.5%) subjects of normal weight, 45 (16.5%) at risk for overweight (BMI >85th <95th percentile age gender) 112 (41%) >/=95th percentile). The outcome measures prevalence...

Late-onset sepsis is associated with significant morbidity and mortality among very low birth weight (VLBW) infants. Our objective was to determine risk factors late-onset present temporal trends in overall pathogen-specific rates.Population-based study by the Israel Neonatal Network on VLBW infants (≤1500 g) born between 1995 2019. required clinical symptoms microbiologic confirmation. Bivariate multivariable analyses were performed identify factors. The period divided into 4 epochs....

OBJECTIVES. Our goals were to (1) study the prevalence of hearing impairment in a large cohort infants with preauricular skin tags or ear pits and compare it that among all other newborns participating our universal newborn screening program during same period (2) evaluate effectiveness transient evoked otoacoustic emissions as hearing-screening tool this population. PATIENTS AND METHODS. During 7.5 years, 68484 screened for impairment, whom 637 (0.93%) had and/or pits. The population was...

Intentional insulin omission is a unique inappropriate compensatory behavior that occurs in patients with type 1 diabetes mellitus, mostly females, who omit or restrict their required doses order to lose weight. Diagnosis of this underlying disorder difficult. We aimed use clinical and laboratory criteria create an algorithm assist the detection intentional omission.The distribution HbA1c levels from 287 (181 females) were used as reference. Data 26 analysed. The Weka (Waikato Environment...

Purpose To illustrate the distribution of Hemoglobin A1c (HbA1c) levels according to age and gender among children, adolescents youth with type 1 diabetes (T1DM). Methods Consecutive HbA1c measurements 349 patients, aged 2 30 years T1DM were obtained from 1995 through 2010. Measurement patients diagnosed celiac disease (n = 20), eating disorders 41) hemoglobinopathy 1) excluded. The study sample comprised 4815 287 patients. Regression percentiles calculated as a function by quantile...

Aplasia cutis congenita associated with epidermolysis bullosa and pyloric atresia is a rare congenital disease in which localized or widespread areas of skin are absent at birth. Alphafetoprotein (AFP) biopsy have been used for prenatal diagnosis this condition. A patient whom normal levels amniotic AFP 16 weeks' gestation presumably excluded the who was risk aplasia described. However, 10 weeks later, ultrasonographic examination revealed hydramnios, dilated stomach, deformed external ear,...

To evaluate the risk for congenital malformations diagnosed at birth following assisted reproductive technology (ART) treatments compared with live births conceived spontaneously.A retrospective cohort study including 9042 ART and 213 288 spontaneously (SC) during period 1997-2004.The was linked to national registry determine outcome of pregnancies malformations.An increased adjusted all observed in SC infants [2.4% versus 1.9%; ORadj = 1.45; 95% CI: 1.26, 1.68]. The singleton 1.8%; 1.41;...

To assess the effectiveness of an intervention programme to improve kindergarten children's eating and leisure habits in Israel.A cluster-randomised controlled trial.Six full-day kindergartens Israel were randomly divided into three groups. Group A received full programme, which included lessons on good daily physical exercise. B a partial only. C, reference group, did not receive any intervention.Children aged 4-6 years (n 204) recruited for study.Objective data weight height collected...

Objective: This study was done to identify factors influencing long-term metabolic control in youth with type 1 diabetes mellitus (T1DM) treated an insulin pump. Research Design and Methods: Data were obtained from retrospective chart review of 113 patients (52 males) T1DM pump for up 7 years. Their mean ± SD age at diagnosis 9.7 5.1 years, that therapy initiation 13.8 6.1 Linear trends changes hemoglobin A1c (HbA1c) levels following insertion evaluated according gender, prior therapy, time...

Evaluation of a multisensory intervention based on the developmental approach provided by parents, during neonatal intensive care unit hospitalization their preterm infants. After guidance parents and implementation program, children were followed up to 2 3 years using scales for evaluation parental stress levels child’s development. Our years’ follow-up study included 41 infants (20 controls 21 who received parental-guided intervention) as part group 95 participated in short-term study. The...

To assess postnatal growth in infants with and without major neonatal morbidities.This study is based on analysis of data collected by the Israel Neonatal Network VLBW (≤1500 g) born from 2009 to 2018. Postnatal was assessed two 5 years epochs: 2009-2013 (n = 4583) 2014-2018 4558). Outcome considered as severe, mild no failure (PNGF). Morbidities included respiratory distress syndrome, bronchopulmonary dysplasia, necrotising enterocolitis, patent ductus arteriosus grades 3-4 intraventricular...

ABSTRACT Background: Patent ductus arteriosus is a risk factor for the development of necrotizing enterocolitis. The use indomethacin to treat patent in preterm infants may either decrease incidence enterocolitis by stabilizing or closing increase its direct constricting effect on mesenteric blood vessels. authors sought evaluate interrelationship between arteriosus, treatment with and very low birth weight infants. Method: Israel National database includes prospectively collected data 99%...

Background Short stature was suggested as a risk factor for diabetes onset among middle age individuals, but whether this is the case young adults unclear. Our goal to assess association between height and incident men. Methods Findings Incident assessed 32,055 men with no history of diabetes, from prospectively followed MELANY cohort. Height measured at two time points; adolescence (mean 17.4±0.3 years) grouped according US-CDC percentiles adulthood 31.0±5.6 years). Cox proportional hazards...

Objective: To investigate the association between delivery mode and necrotizing enterocolitis (NEC) in very preterm (24–31 weeks' gestational age (GA)) very-low-birth-weight (VLBW) (≤1500 g) infants.Design: Population-based observational study using univariate multivariable logistic regression analyses.Setting: The Israel National VLBW infant database 1995–2015.Patients: 20,223 infants, 11,832 singletons 8391 multiples.Main outcome measures: of NEC occurrence to by cesarean section (CS)...